STRINGSTRING
ush1c ush1c gucy2f gucy2f STX3 STX3 rbp3 rbp3 whrnb whrnb or126-1 or126-1 opn6b opn6b espl1 espl1 cib2 cib2 calr3a calr3a pcdh15a pcdh15a pxdn pxdn kif3b kif3b calr3b calr3b Exorh Exorh clrn1 clrn1 pcdh15b pcdh15b ush1gb ush1gb ush2a ush2a gapdh gapdh ENSDARP00000060652 ENSDARP00000060652 gapdhs gapdhs cdh23 cdh23 adgrv1 adgrv1 opn1mw2 opn1mw2 rho rho opn1mw3 opn1mw3 opn1mw1 opn1mw1 opn1mw4 opn1mw4 calr calr rhol rhol whrna whrna
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
gucy2fGuanylate cyclase. (1107 aa)
STX3Zgc:165520; Belongs to the syntaxin family. (285 aa)
rbp3Retinol-binding protein 3. (615 aa)
whrnbWhirlin b. (946 aa)
or126-1Olfactory receptor. (309 aa)
opn6bOpsin 6, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (391 aa)
espl1Extra spindle pole bodies-like 1, separase. (2182 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
calr3aCalreticulin. (418 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
pxdnPeroxidasin. (1460 aa)
kif3bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (775 aa)
calr3bCalreticulin. (417 aa)
ExorhRhodopsin. (168 aa)
clrn1Clrn1 protein. (232 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
ush2aUsher syndrome 2A (autosomal recessive, mild). (5236 aa)
gapdhGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
ENSDARP00000060652Si:ch211-57i17.5. (199 aa)
gapdhsGlyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. (335 aa)
cdh23Cadherin-related 23. (2883 aa)
adgrv1Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa)
opn1mw2Green-sensitive opsin-2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (349 aa)
rhoRhodopsin; Photoreceptor required for image-forming vision at low light intensity. While most salt water fish species use retinal as chromophore, most freshwater fish use 3-dehydroretinal, or a mixture of retinal and 3-dehydroretinal (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by arrestin and terminates signaling (By similarity). (354 aa)
opn1mw3Green-sensitive opsin-3; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (349 aa)
opn1mw1Green-sensitive opsin-1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (349 aa)
opn1mw4Green-sensitive opsin-4; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (349 aa)
calrCalreticulin. (417 aa)
rholRhodopsin. (355 aa)
whrnaWhirlin a. (939 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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