STRINGSTRING
bdnf bdnf sirt3 sirt3 ins ins gsr gsr gpx1a gpx1a gpx8 gpx8 gpx1b gpx1b tnfb tnfb noxo1a noxo1a gpx4b gpx4b ccnd1 ccnd1 gpx9 gpx9 gpx7 gpx7 insb insb il10 il10 stat3 stat3 gpx4a gpx4a sirt1 sirt1 nox1 nox1 egf egf gpx3 gpx3 sod2 sod2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
bdnfBrain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa)
sirt3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (357 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
gsrGlutathione reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (425 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
gpx8Probable glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (210 aa)
gpx1bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
noxo1aNADPH oxidase organizer 1a. (472 aa)
gpx4bGlutathione peroxidase; Belongs to the glutathione peroxidase family. (170 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
gpx9Glutathione peroxidase; Belongs to the glutathione peroxidase family. (140 aa)
gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
il10Interleukin-10. (180 aa)
stat3Signal transducer and activator of transcription. (806 aa)
gpx4aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
sirt1Sirtuin 1. (710 aa)
nox1NADPH oxidase 1. (564 aa)
egfEpidermal growth factor. (1114 aa)
gpx3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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