STRINGSTRING
tp53 tp53 flt1 flt1 prdm1a prdm1a calm2a calm2a ube2ib ube2ib rhoab rhoab aqp4 aqp4 tlr4bb tlr4bb itgb1b.2 itgb1b.2 hmbox1a hmbox1a itgb1a itgb1a ptk2ab ptk2ab nos2b nos2b kdr kdr cd36 cd36 sumo3b sumo3b nfatc1 nfatc1 s1pr2 s1pr2 hnrnpa1b hnrnpa1b socs1a socs1a ido1 ido1 foxp2 foxp2 apln apln prox1a prox1a ilk ilk gata2a gata2a cpt1aa cpt1aa adamts3 adamts3 foxp3a foxp3a ddx21 ddx21 yap1 yap1 vegfc vegfc stat3 stat3 tlr4al tlr4al LOC101886422 LOC101886422 piezo1 piezo1 dtx4a dtx4a tlr4ba tlr4ba ccbe1 ccbe1 nos2a nos2a nr2f2 nr2f2 cd44a cd44a s1pr4 s1pr4 sox18 sox18 ccl19b ccl19b lmo2 lmo2 ccr7 ccr7 vegfd vegfd itgb1b.1 itgb1b.1 lgals8a lgals8a sumo2a sumo2a flt4 flt4 dusp2 dusp2 itgam itgam kdrl kdrl foxo1a foxo1a nos1 nos1 Dtx1 Dtx1 tnfrsf9b tnfrsf9b itgb1b itgb1b ctnnb1 ctnnb1 cd27 cd27 kras kras fat4 fat4 tlr9 tlr9 ephb4a ephb4a lyve1b lyve1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
calm2aCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
ube2ibSUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
aqp4Si:ch211-192k9.1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (320 aa)
tlr4bbToll-like receptor 4b, duplicate b. (819 aa)
itgb1b.2Integrin beta; Belongs to the integrin beta chain family. (613 aa)
hmbox1aHomeobox-containing 1a. (441 aa)
itgb1aIntegrin beta; Belongs to the integrin beta chain family. (798 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
kdrVascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
sumo3bSmall ubiquitin-related modifier. (94 aa)
nfatc1Nuclear factor of-activated T cells 1. (867 aa)
s1pr2Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa)
hnrnpa1bHeterogeneous nuclear ribonucleoprotein A1b. (403 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
ido1Indoleamine 2,3-dioxygenase 1. (435 aa)
foxp2Forkhead box P2. (697 aa)
aplnApelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity). (77 aa)
prox1aProspero homeobox 1a. (739 aa)
ilkIntegrin-linked kinase. (452 aa)
gata2aGATA-binding protein 2a. (456 aa)
cpt1aaCarnitine palmitoyltransferase 1Aa (liver); Belongs to the carnitine/choline acetyltransferase family. (774 aa)
adamts3ADAM metallopeptidase with thrombospondin type 1 motif, 3. (1164 aa)
foxp3aForkhead box protein. (419 aa)
ddx21DEAD (Asp-Glu-Ala-Asp) box helicase 21. (791 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
vegfcVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa)
stat3Signal transducer and activator of transcription. (806 aa)
tlr4alToll-like receptor 4a, like. (816 aa)
LOC101886422ADAM metallopeptidase with thrombospondin type 1 motif, 14. (800 aa)
piezo1Piezo-type mechanosensitive ion channel component. (2436 aa)
dtx4aDeltex 4, E3 ubiquitin ligase a. (704 aa)
tlr4baToll-like receptor 4b, duplicate a. (787 aa)
ccbe1Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
nr2f2Drosophila seven-up homolog/mammalian ARP-1 homolog. (422 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
s1pr4Sphingosine-1-phosphate receptor 4; Belongs to the G-protein coupled receptor 1 family. (389 aa)
sox18SRY-box transcription factor 18. (431 aa)
ccl19bChemokine (C-C motif) ligand 19b. (128 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
ccr7Chemokine (C-C motif) receptor 7; Belongs to the G-protein coupled receptor 1 family. (385 aa)
vegfdVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (272 aa)
itgb1b.1Integrin beta; Belongs to the integrin beta chain family. (787 aa)
lgals8aGalectin. (316 aa)
sumo2aSmall ubiquitin-related modifier. (94 aa)
flt4Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa)
dusp2Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (333 aa)
itgamIntegrin, alpha M (complement component 3 receptor 3 subunit); Belongs to the integrin alpha chain family. (780 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
Dtx1RING-type domain-containing protein. (306 aa)
tnfrsf9bTumor necrosis factor receptor superfamily, member 9b. (281 aa)
itgb1bIntegrin beta; Belongs to the integrin beta chain family. (521 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
cd27CD27 molecule. (248 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
fat4FAT atypical cadherin 4. (4531 aa)
tlr9Toll-like receptor 9; Belongs to the Toll-like receptor family. (1069 aa)
ephb4aEphrin type-B receptor 4a; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (987 aa)
lyve1bLymphatic vessel endothelial hyaluronic receptor 1b. (355 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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