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| | kdrl | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa) |
| | foxo1a | Forkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa) |
| | tfcp2 | Transcription factor CP2. (512 aa) |
| | EML4 | EMAP like 4. (956 aa) |
| | tnfrsf11b | Tumor necrosis factor receptor superfamily, member 11b. (241 aa) |
| | csf1ra | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa) |
| | kras | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (454 aa) |
| | pdgfba | Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (463 aa) |
| | cdkn2a/b | Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (129 aa) |
| | fgfr4 | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa) |
| | hrasa | HRas proto-oncogene, GTPase a. (189 aa) |
| | ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) |
| | asf1ba | Histone chaperone asf1b-A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (197 aa) |
| | akt3a | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | top2a | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa) |
| | ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) |
| | pik3ca | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | incenp | Uncharacterized protein. (815 aa) |
| | cdh28 | Cadherin 28. (795 aa) |
| | pax7a | Transcription factor PAX7C. (507 aa) |
| | notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) |
| | faslg | Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa) |
| | flt1 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa) |
| | cdc25b | Cell division cycle 25B. (563 aa) |
| | mad2l1 | MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa) |
| | ccnh | Cyclin H; Belongs to the cyclin family. (319 aa) |
| | casp3a | Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa) |
| | map2k1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (561 aa) |
| | tcf3a | Transcription factor 3a. (570 aa) |
| | plek2 | Plek2 protein. (361 aa) |
| | myog | Myogenin. (256 aa) |
| | bdnf | Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (270 aa) |
| | fgfr3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | ntrk1 | Tyrosine-protein kinase receptor. (797 aa) |
| | uts1 | Urotensin 1. (138 aa) |
| | rhd | Rh blood group, D antigen; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (423 aa) |
| | aurka | Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa) |
| | tacc3 | Transforming, acidic coiled-coil-containing protein 3. (942 aa) |
| | eif4e1b | Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein. (214 aa) |
| | akt2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | insra | Tyrosine-protein kinase receptor. (1353 aa) |
| | plk2b | Serine/threonine-protein kinase PLK. (657 aa) |
| | mycn | N-myc protein; May function as a transcription factor. (503 aa) |
| | ccnt1 | Cyclin T1; Belongs to the cyclin family. (674 aa) |
| | gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) |
| | bcl2l1 | Bcl-XL-like protein 1. (238 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | foxo3a | Forkhead box O3A. (643 aa) |
| | crkl | V-crk sarcoma virus CT10 oncogene homolog (Avian)-like. (305 aa) |
| | ccnd3 | Cyclin D3; Belongs to the cyclin family. (277 aa) |
| | pax3a | Transcription factor PAX3. (509 aa) |
| | ptk2ab | Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa) |
| | plk4 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as sass6, cenpj/cpap, ccp110, cep135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a possible role in tumorigenes [...] (941 aa) |
| | braf | B-Raf proto-oncogene, serine/threonine kinase. (817 aa) |
| | cdkn1ba | Cyclin-dependent kinase inhibitor 1Ba. (187 aa) |
| | kdr | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa) |
| | cdk7 | Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (345 aa) |
| | ins | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | ccnt2b | Zgc:55690 protein; Belongs to the cyclin family. (569 aa) |
| | ccnt2a | Cyclin T2a; Belongs to the cyclin family. (630 aa) |
| | fus | FUS RNA-binding protein. (541 aa) |
| | nras | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa) |
| | acta1b | Actin alpha 1, skeletal muscle b. (377 aa) |
| | ccnb1 | Cyclin B1; Belongs to the cyclin family. (397 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | cdk9 | Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. (393 aa) |
| | ccnd2a | Cyclin D2, a; Belongs to the cyclin family. (298 aa) |
| | egf | Epidermal growth factor. (1114 aa) |
| | cdkn1bb | Cyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa) |
| | casp3b | Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa) |
| | mdm2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. (475 aa) |
| | cdk5 | Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa) |
| | hells | Helicase, lymphoid-specific. (853 aa) |
| | plk1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | flt3 | Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa) |
| | tacc1 | Transforming, acidic coiled-coil-containing protein 1. (757 aa) |
| | cdk12 | Cyclin-dependent kinase 12. (1293 aa) |
| | ar | Androgen receptor. (868 aa) |
| | prr5a | Proline-rich 5a (renal). (453 aa) |
| | cdk14 | Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily. (324 aa) |
| | pik3c3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa) |
| | bcr | BCR activator of RhoGEF and GTPase. (1341 aa) |
| | src | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa) |
| | pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | cdk19 | Cyclin-dependent kinase 19; Belongs to the protein kinase superfamily. (477 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | insrb | Tyrosine-protein kinase receptor. (1348 aa) |
| | kita | Mast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa) |
| | cenpe | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2690 aa) |
| | brca2 | BRCA2 DNA repair-associated. (2874 aa) |
| | myca | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa) |
| | birc5a | Baculoviral IAP repeat-containing 5a. (190 aa) |
| | rabif | RAB-interacting factor. (132 aa) |
| | eif4ea | Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. (215 aa) |
| | ccnb3 | Cyclin B3; Belongs to the cyclin family. (398 aa) |
| | atrx | ATRX chromatin remodeler. (2013 aa) |
| | bmi1a | Polycomb complex protein BMI-1-A; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin- protein ligase activity of rnf2. (322 aa) |
| | cdk1 | Cell division control protein 2; Belongs to the protein kinase superfamily. (302 aa) |
| | sp1 | Sp1 transcription factor. (594 aa) |
| | fasn | Coiled-coil domain containing 57. (2511 aa) |
| | cdk20 | Cyclin-dependent kinase 20; Involved in cell growth. Activates cdk2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with tbc1d32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing gli2 to be properly activated in response to SHH signaling; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (344 aa) |
| | frs2b | Fibroblast growth factor receptor substrate 2b. (508 aa) |
| | insb | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | ros1 | Tyrosine-protein kinase receptor. (1289 aa) |
| | araf | A-Raf proto-oncogene, serine/threonine kinase. (604 aa) |
| | rictorb | RPTOR-independent companion of MTOR, complex 2b. (1698 aa) |
| | mapk7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1080 aa) |
| | bcl2a | B-cell leukemia/lymphoma 2. (228 aa) |
| | plk3 | Serine/threonine-protein kinase PLK. (660 aa) |
| | grb2b | Growth factor receptor-bound protein 2b. (217 aa) |
| | deptor | DEP domain-containing MTOR-interacting protein. (407 aa) |
| | erbb3a | Erb-b2 receptor tyrosine kinase 3a. (1319 aa) |
| | alk | Tyrosine-protein kinase receptor. (1181 aa) |
| | fgfr2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa) |
| | gdnfa | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | cdk6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (324 aa) |
| | nf1a | Neurofibromin 1a. (2759 aa) |
| | espl1 | Extra spindle pole bodies-like 1, separase. (2182 aa) |
| | plek | Pleckstrin. (352 aa) |
| | tsc2 | TSC complex subunit 2. (1674 aa) |
| | rela | V-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa) |
| | flt4 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa) |
| | ripk2 | Receptor-interacting serine-threonine kinase 2. (457 aa) |
