STRINGSTRING
atg5 atg5 eif2ak3 eif2ak3 bcl2a bcl2a igf3 igf3 cyp19a1a cyp19a1a becn1 becn1 il10 il10 fshr fshr Nox4 Nox4 casp3a casp3a atf6 atf6 tnfb tnfb tnfrsf1a tnfrsf1a mapkapk2b mapkapk2b gpx1a gpx1a myd88 myd88 baxa baxa hsd3b2 hsd3b2 cycsb cycsb mapk14a mapk14a keap1a keap1a ache ache rad51 rad51 sod1 sod1 casp3b casp3b lhcgr lhcgr atg12 atg12 casp8 casp8 casp22 casp22 il1b il1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
eif2ak3Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
igf3Insulin-like growth factor 3. (193 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
becn1Beclin-1; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3- phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 P [...] (447 aa)
il10Interleukin-10. (180 aa)
fshrThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (668 aa)
Nox4NADPH oxidase 4. (246 aa)
casp3aCaspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (282 aa)
atf6Activating transcription factor 6. (653 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
mapkapk2bMAPK-activated protein kinase 2b; Belongs to the protein kinase superfamily. (397 aa)
gpx1aGlutathione peroxidase; Belongs to the glutathione peroxidase family. (191 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
hsd3b2Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; Belongs to the 3-beta-HSD family. (374 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
mapk14aMitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
keap1aKelch-like ECH-associated protein 1A; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non- enzymatic covalent modifications of highly reactive cystei [...] (601 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (340 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
lhcgrLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (708 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (120 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
il1bInterleukin-1. (284 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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