(8 nodes) (2023) Homozygous Knockout of Cep250 Leads to a Relatively Late-Onset Retinal Degeneration and Sensorineural Hearing Loss in Mice. network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cep78	Centrosomal protein 78. (672 aa)
	nek2	NIMA (Never in mitosis gene a)-related kinase 2. (440 aa)
	crocc2	Ciliary rootlet coiled-coil, rootletin family member 2. (1959 aa)
	ush2a	Usher syndrome 2A (autosomal recessive, mild). (5236 aa)
	whrna	Whirlin a. (939 aa)
	whrnb	Whirlin b. (946 aa)
	mgp	Matrix Gla protein. (112 aa)
	clrn1	Clrn1 protein. (232 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cep78	clrn1	ENSDARP00000057314	ENSDARP00000140380	Centrosomal protein 78.	Clrn1 protein.	0.644
cep78	ush2a	ENSDARP00000057314	ENSDARP00000080636	Centrosomal protein 78.	Usher syndrome 2A (autosomal recessive, mild).	0.511
clrn1	cep78	ENSDARP00000140380	ENSDARP00000057314	Clrn1 protein.	Centrosomal protein 78.	0.644
clrn1	ush2a	ENSDARP00000140380	ENSDARP00000080636	Clrn1 protein.	Usher syndrome 2A (autosomal recessive, mild).	0.914
clrn1	whrna	ENSDARP00000140380	ENSDARP00000102025	Clrn1 protein.	Whirlin a.	0.929
clrn1	whrnb	ENSDARP00000140380	ENSDARP00000119523	Clrn1 protein.	Whirlin b.	0.892
crocc2	nek2	ENSDARP00000065237	ENSDARP00000020452	Ciliary rootlet coiled-coil, rootletin family member 2.	NIMA (Never in mitosis gene a)-related kinase 2.	0.708
nek2	crocc2	ENSDARP00000020452	ENSDARP00000065237	NIMA (Never in mitosis gene a)-related kinase 2.	Ciliary rootlet coiled-coil, rootletin family member 2.	0.708
ush2a	cep78	ENSDARP00000080636	ENSDARP00000057314	Usher syndrome 2A (autosomal recessive, mild).	Centrosomal protein 78.	0.511
ush2a	clrn1	ENSDARP00000080636	ENSDARP00000140380	Usher syndrome 2A (autosomal recessive, mild).	Clrn1 protein.	0.914
ush2a	whrna	ENSDARP00000080636	ENSDARP00000102025	Usher syndrome 2A (autosomal recessive, mild).	Whirlin a.	0.993
ush2a	whrnb	ENSDARP00000080636	ENSDARP00000119523	Usher syndrome 2A (autosomal recessive, mild).	Whirlin b.	0.971
whrna	clrn1	ENSDARP00000102025	ENSDARP00000140380	Whirlin a.	Clrn1 protein.	0.929
whrna	ush2a	ENSDARP00000102025	ENSDARP00000080636	Whirlin a.	Usher syndrome 2A (autosomal recessive, mild).	0.993
whrna	whrnb	ENSDARP00000102025	ENSDARP00000119523	Whirlin a.	Whirlin b.	0.563
whrnb	clrn1	ENSDARP00000119523	ENSDARP00000140380	Whirlin b.	Clrn1 protein.	0.892
whrnb	ush2a	ENSDARP00000119523	ENSDARP00000080636	Whirlin b.	Usher syndrome 2A (autosomal recessive, mild).	0.971
whrnb	whrna	ENSDARP00000119523	ENSDARP00000102025	Whirlin b.	Whirlin a.	0.563

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