STRINGSTRING
cttn cttn anxa2a anxa2a rhoab rhoab ehd1b ehd1b cfl1 cfl1 tgfb3 tgfb3 cav3 cav3 anxa2b anxa2b acta1b acta1b ehd2b ehd2b tgfb1a tgfb1a cav2 cav2 ehd4 ehd4 ilk ilk bin1b bin1b ank3a ank3a csk csk eps15 eps15 sptan1 sptan1 cd2ap cd2ap src src zgc:158296 zgc:158296 tgfb5 tgfb5 iqgap1 iqgap1 actr3 actr3 klf7a klf7a ror1 ror1 fmnl2a fmnl2a hcls1 hcls1 limch1a limch1a tgfb1b tgfb1b fyna fyna pacsin2 pacsin2 tpm3 tpm3 cdc42 cdc42 pacsin3 pacsin3 dnm2a dnm2a zgc:101785 zgc:101785 dnm2b dnm2b cav1 cav1 fhod1 fhod1 lmna lmna dmd dmd cfl1l cfl1l cfl2 cfl2 amph amph zgc:172270 zgc:172270
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cttnCortactin. (536 aa)
anxa2aAnnexin. (337 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
ehd1bEH-domain-containing 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (532 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
anxa2bAnnexin. (338 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ehd2bEH-domain-containing 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (543 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
ehd4EH-domain-containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (614 aa)
ilkIntegrin-linked kinase. (452 aa)
bin1bBridging integrator 1b. (364 aa)
ank3aAnkyrin 3a. (4150 aa)
cskTyrosine-protein kinase. (450 aa)
eps15Epidermal growth factor receptor pathway substrate 15. (1039 aa)
sptan1Spectrin alpha, non-erythrocytic 1. (2480 aa)
cd2apCD2-associated protein. (657 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
zgc:158296Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (171 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
iqgap1IQ motif-containing GTPase-activating protein 1. (1655 aa)
actr3Actin-related protein 3; Belongs to the actin family. (231 aa)
klf7aKruppel-like factor 7a. (286 aa)
ror1Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (950 aa)
fmnl2aFormin-like 2a. (1077 aa)
hcls1Hematopoietic cell-specific Lyn substrate 1. (548 aa)
limch1aLIM and calponin homology domains 1a. (1019 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
fynaTyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. (537 aa)
pacsin2Protein kinase C and casein kinase substrate in neurons 2. (490 aa)
tpm3Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
cdc42Cell division cycle 42. (191 aa)
pacsin3Protein kinase C and casein kinase substrate in neurons 3. (377 aa)
dnm2aDynamin 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (860 aa)
zgc:101785Annexin. (326 aa)
dnm2bDynamin 2b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (432 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
fhod1Formin homology 2 domain-containing 1. (1387 aa)
lmnaLamin A; Belongs to the intermediate filament family. (675 aa)
dmdDystrophin. (594 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
amphAmphiphysin. (784 aa)
zgc:172270Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (185 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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