STRINGSTRING
dmrt2a dmrt2a klhl10a klhl10a sox6 sox6 spata7 spata7 cyp21a2 cyp21a2 sox7 sox7 klhl10b.1 klhl10b.1 klhl10b.2 klhl10b.2 nr5a2 nr5a2 cyp1a cyp1a tekt1 tekt1 sox5 sox5 sox17 sox17 gata4 gata4 wnt5b wnt5b spata6 spata6 piwil2 piwil2 sycp2 sycp2 SPATA1 SPATA1 ddx4 ddx4 cyp19a1a cyp19a1a figla figla bmp2b bmp2b nr0b1 nr0b1 wnt4b wnt4b wnt4 wnt4 sox2 sox2 wnt1 wnt1 spata17 spata17 cyp17a2 cyp17a2 sox3 sox3 odf3b odf3b foxl2a foxl2a cyp11c1 cyp11c1 acta1b acta1b dmrta2 dmrta2 ddx5 ddx5 sox8b sox8b bmp15 bmp15 cyp26a1 cyp26a1 wt1a wt1a foxl1 foxl1 hsd17b1 hsd17b1 cyp11a1 cyp11a1 zar1 zar1 hsd17b10 hsd17b10 amh amh bmp2a bmp2a gdf9 gdf9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dmrt2aDoublesex and mab-3-related transcription factor 2a. (507 aa)
klhl10aKelch-like family member 10a. (592 aa)
sox6SRY-box transcription factor 6. (816 aa)
spata7Spermatogenesis-associated 7. (500 aa)
cyp21a2Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (584 aa)
sox7SRY-box transcription factor 7. (390 aa)
klhl10b.1Kelch-like family member 10b, tandem duplicate 1. (614 aa)
klhl10b.2Kelch-like family member 10b, tandem duplicate 2. (606 aa)
nr5a2Nuclear receptor subfamily 5, group A, member 2. (517 aa)
cyp1aCytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (519 aa)
tekt1Tektin 1. (402 aa)
sox5SRY-box transcription factor 5. (759 aa)
sox17SRY-box transcription factor 17. (413 aa)
gata4GATA-binding protein 4. (352 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
spata6Spermatogenesis-associated 6. (455 aa)
piwil2Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in germ cell differentiation and meiosis, independently of the function in transposable elements repression. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. During piRNA biosyn [...] (1087 aa)
sycp2Synaptonemal complex protein 2. (995 aa)
SPATA1Si:dkey-205k8.5. (468 aa)
ddx4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; Belongs to the DEAD box helicase family. (716 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
figlaFolliculogenesis-specific bHLH transcription factor. (220 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
wnt4bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
wnt1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa)
spata17Spermatogenesis-associated 17. (357 aa)
cyp17a2Cytochrome P450, family 17, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family. (495 aa)
sox3Transcription factor Sox-3; Transcriptional activator. (300 aa)
odf3bOuter dense fiber protein 3-B. (257 aa)
foxl2aForkhead box L2-1. (306 aa)
cyp11c1Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (628 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
dmrta2Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development; Belongs to the DMRT family. (440 aa)
ddx5DEAD (Asp-Glu-Ala-Asp) box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
sox8bSRY-box transcription factor 8b. (356 aa)
bmp15Bone morphogenetic protein 15. (384 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
wt1aWT1 transcription factor a. (419 aa)
foxl1Forkhead transcription factor. (360 aa)
hsd17b1Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
cyp11a1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (509 aa)
zar1Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Belongs to the ZAR1 family. (329 aa)
hsd17b10Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
amhAnti-Mullerian hormone. (549 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
gdf9Growth differentiation factor 9. (418 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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