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cox8a cox8a myf5 myf5 elf1 elf1 mbnl3 mbnl3 mapk3 mapk3 msgn1 msgn1 elk4 elk4 mbnl1 mbnl1 synm synm cmya5 cmya5 dysf dysf desma desma aldh1a2 aldh1a2 mylpfa mylpfa cox6b1 cox6b1 sspn sspn nfe2l2a nfe2l2a acta1b acta1b shhb shhb tnnc1b tnnc1b nr3c1 nr3c1 flnca flnca fosab fosab pax3a pax3a tpm4a tpm4a cav3 cav3 hsp70l hsp70l en2a en2a tcap tcap flncb flncb en1a en1a rab7a rab7a vcp vcp calm2a calm2a myog myog myod1 myod1 dmd dmd lmna lmna tpm1 tpm1 cox6b2 cox6b2 nrl nrl ctnnb1 ctnnb1 smyhc1 smyhc1 col22a1 col22a1 pax7a pax7a lama1 lama1 fkrp fkrp tpm2 tpm2 lama2 lama2 map1lc3b map1lc3b tpm3 tpm3 shha shha odc1 odc1 lamp1b lamp1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cox8aCytochrome c oxidase subunit 8A. (76 aa)
myf5Myogenic factor. (237 aa)
elf1E74-like ETS transcription factor 1. (639 aa)
mbnl3Muscleblind-like-splicing regulator 3. (388 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
msgn1Mesogenin-1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By similarity). (131 aa)
elk4ETS transcription factor ELK4. (443 aa)
mbnl1Muscleblind-like-splicing regulator 1. (424 aa)
synmSynemin, intermediate filament protein; Belongs to the intermediate filament family. (1073 aa)
cmya5Cardiomyopathy associated 5 like. (1759 aa)
dysfDysferlin, limb girdle muscular dystrophy 2B (autosomal recessive). (2097 aa)
desmaDesmin a; Belongs to the intermediate filament family. (488 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
cox6b1Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (86 aa)
sspnSarcospan (Kras oncogene-associated gene). (228 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
tnnc1bTroponin C type 1b (slow). (161 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
flncaFilamin C, gamma a (actin-binding protein 280). (2719 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
pax3aTranscription factor PAX3. (509 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
hsp70lNovel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. (643 aa)
en2aHomeobox protein engrailed-2a. (265 aa)
tcapTitin-cap (telethonin). (179 aa)
flncbFilamin C, gamma b (actin-binding protein 280). (2773 aa)
en1aHomeobox protein engrailed-1a. (231 aa)
rab7aRAB7a, member RAS oncogene family. (207 aa)
vcpTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa)
calm2aCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
myogMyogenin. (256 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
dmdDystrophin. (594 aa)
lmnaLamin A; Belongs to the intermediate filament family. (675 aa)
tpm1Tropomyosin 1 (alpha); Belongs to the tropomyosin family. (284 aa)
cox6b2Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (86 aa)
nrlLeucine zipper transcription factor. (412 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
smyhc1Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
col22a1Collagen, type XXII, alpha 1. (1622 aa)
pax7aTranscription factor PAX7C. (507 aa)
lama1Laminin, alpha 1. (3075 aa)
fkrpFukutin-related protein. (536 aa)
tpm2Tropomyosin 2 (beta); Belongs to the tropomyosin family. (284 aa)
lama2Laminin, alpha 2. (845 aa)
map1lc3bMicrotubule-associated protein 1 light chain 3 beta. (122 aa)
tpm3Tropomyosin 3; Belongs to the tropomyosin family. (284 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
odc1Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
lamp1bLysosomal-associated membrane protein 1b. (253 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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