STRINGSTRING
grna grna myo3a myo3a mafa mafa clic5b clic5b clic5a clic5a ncoa3 ncoa3 mafb mafb ogdhl ogdhl tmem183a tmem183a trmu trmu acta1b acta1b thoc1 thoc1 ada ada fgfr3 fgfr3 mafba mafba klhl18 klhl18 cdh23 cdh23 myo7aa myo7aa pcdh15b pcdh15b ctnnb1 ctnnb1 thumpd1 thumpd1 pcdh15a pcdh15a cib2 cib2 cdc42 cdc42 myo15aa myo15aa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
grnaGranulin a. (1049 aa)
myo3aMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa)
mafaV-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a); Belongs to the bZIP family. (325 aa)
clic5bChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (408 aa)
clic5aChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (246 aa)
ncoa3Nuclear receptor coactivator 3. (1497 aa)
mafbTranscription factor Maf; Acts as a transcriptional activator or repressor. Belongs to the bZIP family. Maf subfamily. (327 aa)
ogdhlOxoglutarate dehydrogenase-like. (1008 aa)
tmem183aTransmembrane protein 183A. (364 aa)
trmuMitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Belongs to the MnmA/TRMU family. (416 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
thoc1THO complex 1. (655 aa)
adaAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (362 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
mafbaTranscription factor MafB; May act as a transcriptional activator or repressor. Involved in neurogenesis. Involved in the development of rhombomeres (r) 5 and 6 segments from their common precursor 'proto-segment' in the hindbrain. Belongs to the bZIP family. Maf subfamily. (397 aa)
klhl18Kelch-like family member 18. (576 aa)
cdh23Cadherin-related 23. (2883 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
thumpd1THUMP domain-containing 1. (343 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
cdc42Cell division cycle 42. (191 aa)
myo15aaMyosin XVAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (4115 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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