STRINGSTRING
sufu sufu gli1 gli1 shha shha ENSDARP00000125042 ENSDARP00000125042 poc5 poc5 krt18a.1 krt18a.1 vip vip dlg5a dlg5a zgc:158846 zgc:158846 ces2a ces2a kif6 kif6 ptk7a ptk7a krt8 krt8 ptch2 ptch2 ttc38 ttc38 shhb shhb dmd dmd gli2a gli2a smo smo kif7 kif7 krt4 krt4 ptch1 ptch1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sufuSuppressor of fused homolog. (485 aa)
gli1GLI family zinc finger 1. (1404 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
ENSDARP00000125042Patched 1. (120 aa)
poc5POC5 centriolar protein homolog (Chlamydomonas). (567 aa)
krt18a.1Keratin, type I cytoskeletal 18; When phosphorylated, plays a role in filament reorganization. (431 aa)
vipVasoactive intestinal peptide. (153 aa)
dlg5aDiscs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1926 aa)
zgc:158846Zgc:158846; Belongs to the intermediate filament family. (486 aa)
ces2aCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (555 aa)
kif6Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (761 aa)
ptk7aProtein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa)
krt8Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. (520 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
ttc38Tetratricopeptide repeat protein 38; Belongs to the TTC38 family. (466 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
dmdDystrophin. (594 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
kif7Kinesin-like protein kif7; Acts downstream of smo as an intracellular repressor of hedgehog signaling pathway, mainly through the suppression of gli1 activity. This negative regulatory effect is enhanced in conjunction with the suppressor of fused (sufu) protein. Positively regulates gli2a activity by promoting its dissociation from sufu. Involved in the regulation of microtubular dynamics. (1363 aa)
krt4Keratin 4; Belongs to the intermediate filament family. (497 aa)
ptch1Protein patched homolog 1. (1475 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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