STRINGSTRING
sox4a sox4a mmp2 mmp2 cxcr5 cxcr5 fgfr1a fgfr1a sdcbp2 sdcbp2 msna msna rhoab rhoab smad7 smad7 cd63 cd63 itgb1b.2 itgb1b.2 itgb1a itgb1a epb41b epb41b atg3 atg3 ptk2ab ptk2ab smad3a smad3a dlg4 dlg4 sdcbp sdcbp rhebl1 rhebl1 acta1b acta1b ilk ilk ptpn11a ptpn11a drosha drosha slc6a5 slc6a5 atg12 atg12 src src smad4a smad4a mtor mtor smad2 smad2 rheb rheb dgcr8 dgcr8 arf6b arf6b bcl2a bcl2a pld2 pld2 itgb1b.1 itgb1b.1 atg5 atg5 egfra egfra cdc42 cdc42 atg16l1 atg16l1 tln1 tln1 tln2a tln2a XPO5 XPO5 cdh1 cdh1 itgb1b itgb1b notch1a notch1a ctnnb1 ctnnb1 cav1 cav1 kras kras tln2b tln2b tjp1a tjp1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sox4aTranscription factor SOX. (363 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
cxcr5Chemokine (C-X-C motif) receptor 5; Belongs to the G-protein coupled receptor 1 family. (378 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
sdcbp2Syndecan-binding protein (syntenin) 2. (299 aa)
msnaMoesin a. (579 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
cd63Tetraspanin. (237 aa)
itgb1b.2Integrin beta; Belongs to the integrin beta chain family. (613 aa)
itgb1aIntegrin beta; Belongs to the integrin beta chain family. (798 aa)
epb41bErythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked). (1534 aa)
atg3Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] (317 aa)
ptk2abProtein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1050 aa)
smad3aMothers against decapentaplegic homolog. (425 aa)
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)
sdcbpSyndecan-binding protein (syntenin). (307 aa)
rhebl1Ras homolog, mTORC1-binding-like 1. (184 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ilkIntegrin-linked kinase. (452 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
droshaDrosha ribonuclease III. (1289 aa)
slc6a5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (786 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (120 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
rhebRas homolog, mTORC1-binding. (93 aa)
dgcr8DGCR8 microprocessor complex subunit. (782 aa)
arf6bADP-ribosylation factor 6a; Belongs to the small GTPase superfamily. Arf family. (175 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
pld2Phospholipase. (927 aa)
itgb1b.1Integrin beta; Belongs to the integrin beta chain family. (787 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
cdc42Cell division cycle 42. (191 aa)
atg16l1ATG16 autophagy-related 16-like 1 (S. cerevisiae). (621 aa)
tln1Talin 1. (2544 aa)
tln2aTalin 2a. (2543 aa)
XPO5Si:ch211-233m11.2. (906 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
itgb1bIntegrin beta; Belongs to the integrin beta chain family. (521 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
tln2bTalin 2b. (1537 aa)
tjp1aTight junction protein 1a; Belongs to the MAGUK family. (1689 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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