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pcdh15b pcdh15b capzb capzb cnn1b cnn1b cnn3a cnn3a pcdh15a pcdh15a cib2 cib2 triobpb triobpb eps8l2 eps8l2 X1WCU6_DANRE X1WCU6_DANRE pjvk pjvk espn espn baiap2l2b baiap2l2b ankrd24 ankrd24 whrnb whrnb ppp1r18 ppp1r18 myo10 myo10 ptprq ptprq myo3a myo3a tmie tmie pfn1 pfn1 myh6 myh6 cib3 cib3 whrna whrna morn4 morn4 fscn2b fscn2b pfn2 pfn2 TMC1 TMC1 ripor2 ripor2 fscn1a fscn1a coro1a coro1a twf2 twf2 acta1b acta1b cnn3b cnn3b actb1 actb1 pfn2l pfn2l cnn2 cnn2 clic5a clic5a clic5b clic5b lmo7a lmo7a cdh23 cdh23 gpsm2 gpsm2 cfl1 cfl1 cobl cobl myo3b myo3b isl1 isl1 cfl2 cfl2 cnn1a cnn1a cfl1l cfl1l ush1gb ush1gb gpsm2l gpsm2l WDR1 WDR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pcdh15bProtocadherin-related 15b. (1907 aa)
capzbF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
cnn1bCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (296 aa)
cnn3aCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (329 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
triobpbTRIO and F-actin-binding protein b. (532 aa)
eps8l2EPS8-like 2. (670 aa)
X1WCU6_DANREProfilin; Belongs to the profilin family. (127 aa)
pjvkPejvakin. (361 aa)
espnEspin. (873 aa)
baiap2l2bBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. (516 aa)
ankrd24Ankyrin repeat domain 24. (1091 aa)
whrnbWhirlin b. (946 aa)
ppp1r18Protein phosphatase 1, regulatory subunit 18. (1319 aa)
myo10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
ptprqProtein tyrosine phosphatase receptor type Q. (2301 aa)
myo3aMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa)
tmieTransmembrane inner ear. (231 aa)
pfn1Profilin; Belongs to the profilin family. (141 aa)
myh6Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1936 aa)
cib3Calcium and integrin-binding family member 3. (180 aa)
whrnaWhirlin a. (939 aa)
morn4MORN repeat-containing 4. (146 aa)
fscn2bFascin. (490 aa)
pfn2Profilin; Belongs to the profilin family. (140 aa)
TMC1Transmembrane channel-like protein 1; Probable ion channel required for the normal function of hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery ; Belongs to the TMC family. (990 aa)
ripor2Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa)
fscn1aFascin. (491 aa)
coro1aCoronin; Belongs to the WD repeat coronin family. (455 aa)
twf2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (347 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
cnn3bCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (331 aa)
actb1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
pfn2lProfilin; Belongs to the profilin family. (139 aa)
cnn2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (307 aa)
clic5aChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (246 aa)
clic5bChloride intracellular channel protein; Belongs to the chloride channel CLIC family. (408 aa)
lmo7aLIM domain 7a. (1826 aa)
cdh23Cadherin-related 23. (2883 aa)
gpsm2G protein-signaling modulator 2. (649 aa)
cfl1Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa)
coblProtein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal develop [...] (1327 aa)
myo3bMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
cfl2Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
cnn1aCalponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (287 aa)
cfl1lCofilin 1 (non-muscle),-like; Belongs to the actin-binding proteins ADF family. (163 aa)
ush1gbUsher syndrome 1Gb (autosomal recessive). (488 aa)
gpsm2lG protein-signaling modulator 2,-like. (679 aa)
WDR1WD repeat domain 1. (606 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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