STRINGSTRING
mtpn mtpn sirt2 sirt2 chuk chuk hsp90ab1 hsp90ab1 nfkbiab nfkbiab slc35b2 slc35b2 INSM2 INSM2 pold1 pold1 rps5 rps5 rel rel il10 il10 fam177a1 fam177a1 pola1 pola1 nfkbiaa nfkbiaa eef1a1b eef1a1b rab6a rab6a eed eed rela rela fxyd6 fxyd6 cxcl8a cxcl8a il1b il1b ccr2-2 ccr2-2 ccr2 ccr2 gjd1a gjd1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtpnMyotrophin; Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity); Belongs to the myotrophin family. (118 aa)
sirt2NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (By similarity). Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Deacetylates histone H4 at 'Lys-16' (H4K16ac) at the VEGFA promoter. Thereby con [...] (379 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
hsp90ab1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (725 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
INSM2INSM transcriptional repressor 2. (449 aa)
pold1DNA polymerase. (1105 aa)
rps5Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
relV-rel avian reticuloendotheliosis viral oncogene homolog. (596 aa)
il10Interleukin-10. (180 aa)
fam177a1Family with sequence similarity 177 member A1. (206 aa)
pola1DNA polymerase. (1468 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
eef1a1bElongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
rab6aRAB6A, member RAS oncogene family. (208 aa)
eedPolycomb protein eed; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (443 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
fxyd6FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (99 aa)
cxcl8aInterleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (98 aa)
il1bInterleukin-1. (284 aa)
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
gjd1aGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (299 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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