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gata5 gata5 myod1 myod1 myog myog tbx6 tbx6 gfi1aa gfi1aa hand2 hand2 dab2 dab2 elavl3 elavl3 pax3a pax3a ap1m2 ap1m2 etv2 etv2 cebpa cebpa hist2h2l hist2h2l fmoda fmoda notch3 notch3 mylpfa mylpfa aldh1a2 aldh1a2 myb myb fli1a fli1a pax2a pax2a drl drl elk4 elk4 pax7b pax7b myf5 myf5 runx1 runx1 fn1a fn1a tbx16l tbx16l stab2 stab2 gata2b gata2b actb2 actb2 spock3 spock3 myh9a myh9a X1WHF1_DANRE X1WHF1_DANRE axin2 axin2 mib1 mib1 fbn2b fbn2b kdrl kdrl gata6 gata6 notch1a notch1a eef1a1l1 eef1a1l1 npas4l npas4l phldb1a phldb1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gata5Transcription factor gata5. (383 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
tbx6T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
gfi1aaGrowth factor-independent 1A transcription repressor a. (385 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
dab2DAB adaptor protein 2. (589 aa)
elavl3ELAV-like protein; Belongs to the RRM elav family. (359 aa)
pax3aTranscription factor PAX3. (509 aa)
ap1m2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (424 aa)
etv2ETS variant transcription factor 2. (366 aa)
cebpaCCAAT/enhancer-binding protein. (288 aa)
hist2h2lHistone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
fmodaFibromodulin a. (342 aa)
notch3Notch receptor 3. (2468 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
mybV-myb avian myeloblastosis viral oncogene homolog. (641 aa)
fli1aFli-1 proto-oncogene, ETS transcription factor a. (451 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
drlZinc finger protein draculin. (411 aa)
elk4ETS transcription factor ELK4. (443 aa)
pax7bPaired box protein 7b. (510 aa)
myf5Myogenic factor. (237 aa)
runx1Runt-related transcription factor. (451 aa)
fn1aFibronectin 1a. (2480 aa)
tbx16lT-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa)
stab2Stabilin 2. (2543 aa)
gata2bGATA-binding protein 2b. (428 aa)
actb2Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
spock3SPARC (osteonectin), cwcv and kazal-like domains proteoglycan 3. (384 aa)
myh9aMyosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1964 aa)
X1WHF1_DANREHistone H2B; Belongs to the histone H2B family. (124 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
fbn2bFibrillin 2b. (2868 aa)
kdrlVascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
gata6GATA-binding protein 6. (501 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
eef1a1l1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
phldb1aPleckstrin homology-like domain, family B, member 1a. (1455 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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