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fgf2 fgf2 cdh1 cdh1 notch1a notch1a il1b il1b ccr2-2 ccr2-2 ccr2 ccr2 vcam1b vcam1b angpt4 angpt4 egfra egfra tgfb2 tgfb2 ccl20b ccl20b cdh2 cdh2 tgfb1b tgfb1b bmp7b bmp7b cd44a cd44a il13 il13 il10 il10 tgfb5 tgfb5 stat3 stat3 il11b il11b cxcr2 cxcr2 egf egf il22 il22 mmp9 mmp9 cxcr4b cxcr4b ccl38a.5 ccl38a.5 tgfb1a tgfb1a cxcl12a cxcl12a notch1b notch1b angpt1 angpt1 socs3a socs3a rtn4r rtn4r tgfb3 tgfb3 bmp7a bmp7a tnfb tnfb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
cdh1Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
il1bInterleukin-1. (284 aa)
ccr2-2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (360 aa)
ccr2Chemokine (C-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (354 aa)
vcam1bVascular cell adhesion molecule 1b. (808 aa)
angpt4Angiopoietin 4. (499 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
ccl20bC-C motif chemokine. (102 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
bmp7bBone morphogenetic protein 7b. (427 aa)
cd44aCD44 molecule (Indian blood group) a. (392 aa)
il13Interleukin 4/13A. (157 aa)
il10Interleukin-10. (180 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
stat3Signal transducer and activator of transcription. (806 aa)
il11bInterleukin 11b. (192 aa)
cxcr2Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (340 aa)
egfEpidermal growth factor. (1114 aa)
il22Interleukin 22. (213 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
cxcr4bChemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa)
ccl38a.5C-C motif chemokine. (103 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
cxcl12aChemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa)
notch1bNotch receptor 1b. (2465 aa)
angpt1Angiopoietin 1. (513 aa)
socs3aSuppressor of cytokine-signaling 3a. (207 aa)
rtn4rReticulon 4 receptor. (479 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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