Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aplnr2 | aplnra | ENSDARP00000133169 | ENSDARP00000068614 | Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. | Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | 0.906 |
| aplnr2 | aplnrb | ENSDARP00000133169 | ENSDARP00000108783 | Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. | Apelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | 0.905 |
| aplnra | aplnr2 | ENSDARP00000068614 | ENSDARP00000133169 | Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.906 |
| aplnra | aplnrb | ENSDARP00000068614 | ENSDARP00000108783 | Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | Apelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | 0.903 |
| aplnrb | aplnr2 | ENSDARP00000108783 | ENSDARP00000133169 | Apelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.905 |
| aplnrb | aplnra | ENSDARP00000108783 | ENSDARP00000068614 | Apelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | Apelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] | 0.903 |
| caspa | caspbl | ENSDARP00000034228 | ENSDARP00000113551 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Caspase b,-like; Belongs to the peptidase C14A family. | 0.908 |
| caspa | cxcr2 | ENSDARP00000034228 | ENSDARP00000071727 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.431 |
| caspa | il1b | ENSDARP00000034228 | ENSDARP00000140751 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Interleukin-1. | 0.992 |
| caspa | stat1a | ENSDARP00000034228 | ENSDARP00000015753 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Signal transducer and activator of transcription. | 0.576 |
| caspa | stat3 | ENSDARP00000034228 | ENSDARP00000095292 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Signal transducer and activator of transcription. | 0.595 |
| caspa | tlr4al | ENSDARP00000034228 | ENSDARP00000098602 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Toll-like receptor 4a, like. | 0.539 |
| caspa | tlr4ba | ENSDARP00000034228 | ENSDARP00000104680 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Toll-like receptor 4b, duplicate a. | 0.535 |
| caspa | tlr4bb | ENSDARP00000034228 | ENSDARP00000028819 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Toll-like receptor 4b, duplicate b. | 0.565 |
| caspa | tnfb | ENSDARP00000034228 | ENSDARP00000010728 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Tumor necrosis factor b (TNF superfamily, member 2). | 0.828 |
| caspa | txnipa | ENSDARP00000034228 | ENSDARP00000052420 | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | Thioredoxin-interacting protein a. | 0.607 |
| caspbl | caspa | ENSDARP00000113551 | ENSDARP00000034228 | Caspase b,-like; Belongs to the peptidase C14A family. | Caspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] | 0.908 |
| caspbl | cxcr2 | ENSDARP00000113551 | ENSDARP00000071727 | Caspase b,-like; Belongs to the peptidase C14A family. | Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.427 |
| caspbl | il1b | ENSDARP00000113551 | ENSDARP00000140751 | Caspase b,-like; Belongs to the peptidase C14A family. | Interleukin-1. | 0.990 |
| caspbl | stat1a | ENSDARP00000113551 | ENSDARP00000015753 | Caspase b,-like; Belongs to the peptidase C14A family. | Signal transducer and activator of transcription. | 0.506 |
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