STRINGSTRING
micu1 micu1 KCNIP1 KCNIP1 RYR2 RYR2 ppef1 ppef1 plcd1a plcd1a CABP4 CABP4 eps15l1a eps15l1a calm2b calm2b dgkb dgkb actn4 actn4 ENSDARP00000150791 ENSDARP00000150791 nox5 nox5 rab11fip3 rab11fip3 LOC567728 LOC567728 cabp1b cabp1b rcvrnb rcvrnb caln1 caln1 cabp4 cabp4 plcd4a plcd4a dgkab dgkab lcp1 lcp1 capn3a capn3a ninl ninl rhot1a rhot1a rhot1b rhot1b rhbdl3 rhbdl3 mcc mcc cabp2a cabp2a cetn2 cetn2 calm3a calm3a cib1 cib1 eps15l1b eps15l1b fstl4 fstl4 myl12.1 myl12.1 capsla capsla ncs1a ncs1a RASGRP2 RASGRP2 guca1e guca1e capn8 capn8 slc25a12 slc25a12 myl10 myl10 DST DST micu3a micu3a ppef2a ppef2a myl2a myl2a ENSDARP00000132536 ENSDARP00000132536 capn2a capn2a slc25a13 slc25a13 fkbp10a fkbp10a cib2 cib2 kcnip3b kcnip3b vsnl1b vsnl1b calml4b calml4b wdr95 wdr95 efcab2 efcab2 slc25a23a slc25a23a rcvrn3 rcvrn3 vsnl1a vsnl1a kcnip2 kcnip2 actn1 actn1 plcd4b plcd4b pvalb7 pvalb7 caln2 caln2 macf1b macf1b slc25a23b slc25a23b efcab7 efcab7 zgc:153867 zgc:153867 pvalb6 pvalb6 capns1a capns1a gpd2 gpd2 myl12.2 myl12.2 necab2 necab2 macf1a macf1a E9QFE7_DANRE E9QFE7_DANRE myl2b myl2b itsn1 itsn1 cabp5a cabp5a calb1 calb1 actn2b actn2b ppp3r1a ppp3r1a rcn2 rcn2 cracr2ab cracr2ab hpcal1 hpcal1 capslb capslb calua calua chp1 chp1 pls1 pls1 ncaldb ncaldb rab11fip4a rab11fip4a myl6 myl6 KCNIP4 KCNIP4 efhd2 efhd2 cib3 cib3 slc25a24l slc25a24l myl9b myl9b LOC100329495 LOC100329495 zgc:55262 zgc:55262 rasef rasef rasgrp3 rasgrp3 calml4a calml4a pvalb9 pvalb9 capn1b capn1b tnnc2 tnnc2 ncalda ncalda sdf4 sdf4 lpcat1 lpcat1 hpcal4 hpcal4 zgc:162879 zgc:162879 plcd3a plcd3a rcn1 rcn1 sptan1 sptan1 efhb efhb ppp3r1b ppp3r1b eps15 eps15 cracr2aa cracr2aa slc25a25b slc25a25b duox duox rasgrp2 rasgrp2 usp32 usp32 micu3b micu3b efcab1 efcab1 itsn2b itsn2b cabp7b cabp7b dgkaa dgkaa scgn scgn sri sri plcd3b plcd3b plch1 plch1 capn2b capn2b E9QFN0_DANRE E9QFN0_DANRE nucb1 nucb1 cracr2b cracr2b mylpfa mylpfa lpcat2 lpcat2 cabp2b cabp2b rcvrna rcvrna guca1g guca1g fkbp10b fkbp10b guca1d guca1d calm3b calm3b efcab11 efcab11 efhd1 efhd1 capn3b capn3b itsn2a itsn2a ncs1b ncs1b Q1LUM5_DANRE Q1LUM5_DANRE rhot2 rhot2 cetn4 cetn4 calb2a calb2a myl9a myl9a rcn3 rcn3 pvalb5 pvalb5 pvalb8 pvalb8 pvalb1 pvalb1 pls3 pls3 tnnc1b tnnc1b E7F7H4_DANRE E7F7H4_DANRE calb2b calb2b nucb2a nucb2a nucb2b nucb2b calm1b calm1b plcd1b plcd1b capn1a capn1a capn2l capn2l cabp5b cabp5b B8JK25_DANRE B8JK25_DANRE guca1c guca1c myl7 myl7 calm1a calm1a necab1 necab1 pef1 pef1 slc25a24 slc25a24 pvalb4 pvalb4 pvalb3 pvalb3 kcnip1b kcnip1b tnnc1a tnnc1a calub calub GCA GCA mylpfb mylpfb fkbp9 fkbp9 capns1b capns1b guca1a guca1a pvalb2 pvalb2 guca1b guca1b mylz3 mylz3 capn9 capn9 cabp1a cabp1a cetn3 cetn3 hpca hpca rcvrn2 rcvrn2 efhc2 efhc2 calm2a calm2a pdcd6 pdcd6 chp2 chp2 actn3a actn3a myl1 myl1 plch2a plch2a actn3b actn3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
micu1Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. micu1 and micu2 form a disulfide-linked heterodimer that stimulates and inhibits mcu activity, depending on the concentration of calcium. Micu1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of mcu at low concentration of calcium, preventing channel opening. Enhances mcu opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. (493 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (232 aa)
RYR2Uncharacterized protein. (4478 aa)
ppef1Serine/threonine-protein phosphatase with EF-hands. (729 aa)
plcd1aPhosphoinositide phospholipase C. (781 aa)
CABP4Si:cabz01076231.1. (218 aa)
eps15l1aEpidermal growth factor receptor pathway substrate 15-like 1a. (921 aa)
calm2bCalmodulin; Belongs to the calmodulin family. (161 aa)
dgkbDiacylglycerol kinase. (771 aa)
actn4Actinin, alpha 4. (923 aa)
ENSDARP00000150791Uncharacterized protein. (223 aa)
nox5NADPH oxidase, EF-hand calcium-binding domain 5. (735 aa)
rab11fip3Rab11 family-interacting protein 3. (1875 aa)
LOC567728Diacylglycerol kinase. (886 aa)
cabp1bCalcium-binding protein 1b. (167 aa)
rcvrnbRecoverin-1b. (203 aa)
caln1Calneuron 1. (260 aa)
cabp4Calcium-binding protein 4. (229 aa)
plcd4aPhosphoinositide phospholipase C. (761 aa)
dgkabDiacylglycerol kinase. (727 aa)
lcp1Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells (By similarity). (624 aa)
capn3aCalpain 3a, (p94); Belongs to the peptidase C2 family. (725 aa)
ninlNinein-like. (1303 aa)
rhot1aMitochondrial Rho GTPase 1-A; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (619 aa)
rhot1bMitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (660 aa)
rhbdl3Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family. (407 aa)
mccMCC regulator of WNT-signaling pathway. (975 aa)
cabp2aCalcium-binding protein 2a. (236 aa)
cetn2Centrin, EF-hand protein, 2. (172 aa)
calm3aCalmodulin 3a (phosphorylase kinase, delta). (149 aa)
cib1Calcium and integrin-binding 1 (calmyrin). (188 aa)
eps15l1bEpidermal growth factor receptor pathway substrate 15 like 1. (535 aa)
fstl4Follistatin-like 4. (825 aa)
myl12.1Myosin, light chain 12, genome duplicate 1. (172 aa)
capslaCalcyphosine-like a. (188 aa)
ncs1aNeuronal calcium sensor 1a. (190 aa)
RASGRP2RAS guanyl releasing protein 2. (528 aa)
guca1eGuanylate cyclase activator 1e. (198 aa)
capn8Calpain 8; Belongs to the peptidase C2 family. (701 aa)
slc25a12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (682 aa)
myl10Myosin, light chain 10, regulatory. (167 aa)
DSTDystonin. (3849 aa)
micu3aMitochondrial calcium uptake family, member 3a. (445 aa)
ppef2aSerine/threonine-protein phosphatase with EF-hands. (751 aa)
myl2aMyosin, light chain 2a, regulatory, cardiac, slow. (169 aa)
ENSDARP00000132536Si:ch211-103a14.5. (199 aa)
capn2aCalpain 2, (m/II) large subunit a; Belongs to the peptidase C2 family. (698 aa)
slc25a13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (664 aa)
fkbp10aPeptidylprolyl isomerase. (563 aa)
cib2Calcium and integrin-binding family member 2. (187 aa)
kcnip3bKv channel-interacting protein 3b, calsenilin. (259 aa)
vsnl1bVisinin-like 1b. (191 aa)
calml4bCalmodulin-like 4b. (169 aa)
wdr95WD40 repeat domain 95. (951 aa)
efcab2EF-hand calcium-binding domain 2. (168 aa)
slc25a23aSolute carrier family 25 member 23a; Belongs to the mitochondrial carrier (TC 2.A.29) family. (477 aa)
rcvrn3Recoverin 3. (191 aa)
vsnl1aSi:dkey-30j22.11 protein. (191 aa)
kcnip2Kv channel-interacting protein 2. (207 aa)
actn1Actinin, alpha 1. (902 aa)
plcd4bPhosphoinositide phospholipase C. (753 aa)
pvalb7Parvalbumin-7; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
caln2Calneuron 2. (218 aa)
macf1bMicrotubule actin crosslinking factor 1b. (241 aa)
slc25a23bSolute carrier family 25 member 23b; Belongs to the mitochondrial carrier (TC 2.A.29) family. (481 aa)
efcab7EF-hand calcium-binding domain 7. (606 aa)
zgc:153867Zgc:153867. (180 aa)
pvalb6Parvalbumin isoform 4b; Belongs to the parvalbumin family. (109 aa)
capns1aCalpain, small subunit 1 a. (216 aa)
gpd2Glycerol-3-phosphate dehydrogenase 2 (mitochondrial). (726 aa)
myl12.2Myosin, light chain 12, genome duplicate 2. (172 aa)
necab2N-terminal EF-hand calcium-binding protein 2. (428 aa)
macf1aMicrotubule actin crosslinking factor 1a. (5754 aa)
E9QFE7_DANRESi:rp71-17i16.4. (161 aa)
myl2bMyosin, light polypeptide 2, regulatory, cardiac, slow. (168 aa)
itsn1Intersectin 1 (SH3 domain protein). (1722 aa)
cabp5aCalcium-binding protein 5a. (165 aa)
calb1Calbindin 1. (260 aa)
actn2bActinin, alpha 2b. (894 aa)
ppp3r1aProtein phosphatase 3, regulatory subunit B, alpha a. (170 aa)
rcn2Reticulocalbin 2. (325 aa)
cracr2abCalcium release-activated channel regulator 2Ab. (773 aa)
hpcal1Hippocalcin-like 1. (193 aa)
capslbCalcyphosine-like b. (248 aa)
caluaCalumenin-A; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity). (317 aa)
chp1Calcineurin-like EF-hand protein 1. (194 aa)
pls1Plastin 1 (I isoform). (665 aa)
ncaldbNeurocalcin-delta B; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). (192 aa)
rab11fip4aRab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa)
myl6Myosin, light chain 6, alkali, smooth muscle and non-muscle. (164 aa)
KCNIP4Potassium voltage-gated channel interacting protein 4. (229 aa)
efhd2EF-hand domain family, member D2. (233 aa)
cib3Calcium and integrin-binding family member 3. (180 aa)
slc25a24lSolute carrier family 25 member 24,-like; Belongs to the mitochondrial carrier (TC 2.A.29) family. (448 aa)
myl9bMyosin, light polypeptide 9, regulatory. (173 aa)
LOC100329495Uncharacterized protein. (215 aa)
zgc:55262Zgc:55262; Belongs to the peptidase C2 family. (704 aa)
rasefRas and EF-hand domain-containing protein. (706 aa)
rasgrp3RAS guanyl-releasing protein 3 (calcium and DAG-regulated). (708 aa)
calml4aCalmodulin-like 4a. (153 aa)
pvalb9Parvalbumin 9; Belongs to the parvalbumin family. (109 aa)
capn1bCalpain 1, (mu/I) large subunit b; Belongs to the peptidase C2 family. (700 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
ncaldaNeurocalcin-delta A; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). (193 aa)
sdf445 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family. (356 aa)
lpcat1Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). (517 aa)
hpcal4Hippocalcin-like 4. (191 aa)
zgc:162879Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP. (663 aa)
plcd3a1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores (By similarity). (784 aa)
rcn1Reticulocalbin 1, EF-hand calcium-binding domain. (320 aa)
sptan1Spectrin alpha, non-erythrocytic 1. (2480 aa)
efhbEF-hand domain family, member B. (585 aa)
ppp3r1bProtein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (170 aa)
eps15Epidermal growth factor receptor pathway substrate 15. (1039 aa)
cracr2aaCalcium release activated channel regulator 2A. (718 aa)
slc25a25bCalcium-binding mitochondrial carrier protein SCaMC-2-B; Calcium-dependent mitochondrial solute carrier. Belongs to the mitochondrial carrier (TC 2.A.29) family. (524 aa)
duoxDual oxidase. (1519 aa)
rasgrp2RAS guanyl-releasing protein 2 (calcium and DAG-regulated). (579 aa)
usp32Ubiquitin-specific peptidase 32; Belongs to the peptidase C19 family. (1585 aa)
micu3bMitochondrial calcium uptake family, member 3b. (484 aa)
efcab1EF-hand calcium-binding domain 1. (216 aa)
itsn2bIntersectin 2b. (1741 aa)
cabp7bCalcium-binding protein 7b. (213 aa)
dgkaaDiacylglycerol kinase. (727 aa)
scgnSecretagogin. (272 aa)
sriSorcin. (190 aa)
plcd3bPhosphoinositide phospholipase C. (769 aa)
plch1Phosphoinositide phospholipase C. (1745 aa)
capn2bCalpain 2, (m/II) large subunit b; Belongs to the peptidase C2 family. (696 aa)
E9QFN0_DANRESi:dkeyp-50d11.2; Belongs to the peptidase C2 family. (704 aa)
nucb1Nucleobindin 1. (454 aa)
cracr2bEF-hand calcium-binding domain-containing protein 4A; Belongs to the EFCAB4 family. (408 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
lpcat2Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. May catalyze the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3- phosphocholine. May also cataylze the conversion of as well 1-O-alkyl- sn-glycero-3-phosphocholine to 1-O-alkyl-2-acetyl-sn-glycero-3- phosphocholine and 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (By similarity). (529 aa)
cabp2bCalcium-binding protein 2b. (215 aa)
rcvrnaRecoverin-1a. (203 aa)
guca1gGuanylate cyclase activator 1g. (187 aa)
fkbp10bPeptidylprolyl isomerase. (614 aa)
guca1dGuanylate cyclase activating protein 4. (185 aa)
calm3bCalmodulin 3b (phosphorylase kinase, delta). (149 aa)
efcab11EF-hand calcium-binding domain-containing protein 11. (167 aa)
efhd1EF-hand domain family, member D1. (227 aa)
capn3bCalpain 3b; Belongs to the peptidase C2 family. (723 aa)
itsn2aIntersectin 2a. (1665 aa)
ncs1bFrequenin homolog b (Drosophila). (190 aa)
Q1LUM5_DANRESi:ch211-245j22.3. (194 aa)
rhot2Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). (617 aa)
cetn4Centrin 4. (171 aa)
calb2aCalbindin 2, like. (271 aa)
myl9aMyosin, light chain 9a, regulatory. (174 aa)
rcn3Reticulocalbin 3, EF-hand calcium-binding domain. (316 aa)
pvalb5Parvalbumin isoform 2a; Belongs to the parvalbumin family. (108 aa)
pvalb8Pvalb8 protein; Belongs to the parvalbumin family. (109 aa)
pvalb1Parvalbumin isoform 1d; Belongs to the parvalbumin family. (109 aa)
pls3Plastin 3 (T isoform). (627 aa)
tnnc1bTroponin C type 1b (slow). (161 aa)
E7F7H4_DANRESi:ch211-145b13.5. (225 aa)
calb2bCalbindin 2b. (269 aa)
nucb2aNucleobindin 2a. (496 aa)
nucb2bNucleobindin 2b. (430 aa)
calm1bCalmodulin 1b. (149 aa)
plcd1bPhosphoinositide phospholipase C. (749 aa)
capn1aCalpain 1, (mu/I) large subunit a; Belongs to the peptidase C2 family. (704 aa)
capn2lCalpain 2, (m/II) large subunit,-like; Belongs to the peptidase C2 family. (700 aa)
cabp5bCalcium-binding protein 5b. (169 aa)
B8JK25_DANRESi:dkey-256e7.5. (355 aa)
guca1cGuanylate cyclase-activating protein 3. (188 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
calm1aCalmodulin 1a. (149 aa)
necab1N-terminal EF-hand calcium-binding protein 1. (348 aa)
pef1Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Acts as a negative regulator of ER-Golgi transport (By similarity). (270 aa)
slc25a24Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitoc [...] (477 aa)
pvalb4Pvalb4 protein; Belongs to the parvalbumin family. (109 aa)
pvalb3Parvalbumin isoform 1b; Belongs to the parvalbumin family. (109 aa)
kcnip1bKv channel-interacting protein 1 b. (215 aa)
tnnc1aTroponin C type 1a (slow). (161 aa)
calubCalumenin-B; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase ggcx. Binds 7 calcium ions with a low affinity (By similarity). (315 aa)
GCAZgc:92027. (205 aa)
mylpfbMyosin light chain, phosphorylatable, fast skeletal muscle b. (170 aa)
fkbp9Peptidylprolyl isomerase. (564 aa)
capns1bCalpain, small subunit 1 b. (213 aa)
guca1aGuanylate cyclase activator 1A. (189 aa)
pvalb2Parvalbumin-2; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
guca1bGuanylate cyclase-activating protein 2. (197 aa)
mylz3Fast skeletal muscle myosin light polypeptide 3. (151 aa)
capn9Calpain 9; Belongs to the peptidase C2 family. (688 aa)
cabp1aCalcium-binding protein 1a. (186 aa)
cetn3Centrin 3. (167 aa)
hpcaHippocalcin. (193 aa)
rcvrn2Recoverin-2a. (193 aa)
efhc2EF-hand domain-containing family member C2. (748 aa)
calm2aCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
pdcd6Programmed cell death 6. (185 aa)
chp2Calcineurin-like EF-hand protein 2. (195 aa)
actn3aActinin alpha 3a. (896 aa)
myl1Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa)
plch2aPhosphoinositide phospholipase C. (1534 aa)
actn3bActinin alpha 3b. (898 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (22%) [HD]