(47 nodes) Laminin-type epidermal growth factor-like domai network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ntng1a	Netrin g1a. (546 aa)
	ENSDARP00000155312	Uncharacterized protein. (645 aa)
	megf10	Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa)
	lama3	Laminin, alpha 3. (1711 aa)
	ENSDARP00000145842	Uncharacterized protein. (313 aa)
	LOC559501	Vav 3 guanine nucleotide exchange factor b. (471 aa)
	ntn5	Netrin 5. (839 aa)
	hspg2	Heparan sulfate proteoglycan 2. (3462 aa)
	zgc:158328	Zgc:158328. (846 aa)
	lama1	Laminin, alpha 1. (3075 aa)
	ntn1a	Netrin-1a. (603 aa)
	agrn	Agrin. (1926 aa)
	ntn4	Netrin 4. (639 aa)
	lama2	Laminin, alpha 2. (845 aa)
	lamb1a	Laminin, beta 1a. (1785 aa)
	ntn2	Netrin 2. (609 aa)
	ntng2b	Netrin g2b. (230 aa)
	lamb2	Laminin, beta 2 (laminin S). (1782 aa)
	megf6a	Multiple EGF-like-domains 6a. (1446 aa)
	F1R9B8_DANRE	Si:ch211-241e1.3. (1347 aa)
	pear1	Platelet endothelial aggregation receptor 1. (1020 aa)
	megf8	Multiple EGF-like-domains 8. (2870 aa)
	lamc3	Laminin, gamma 3. (1643 aa)
	celsr3	Cadherin, EGF LAG seven-pass G-type receptor 3. (2065 aa)
	F1REG9_DANRE	Si:ch211-158d24.2. (605 aa)
	nagpa	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (605 aa)
	celsr1b	Cadherin EGF LAG seven-pass G-type receptor 1b; Belongs to the G-protein coupled receptor 2 family. (3006 aa)
	megf6b	Multiple EGF-like-domains 6b. (1454 aa)
	ntng2a	Netrin g2a. (522 aa)
	lamc2	Laminin, gamma 2. (736 aa)
	A2CEV2_DANRE	Si:dkey-220k22.1. (574 aa)
	megf11	Multiple EGF-like-domains 11. (1114 aa)
	atrnl1a	Attractin-like 1a. (1400 aa)
	atrn	Attractin. (1383 aa)
	E7EXX6_DANRE	Si:dkey-202e22.2. (642 aa)
	ush2a	Usher syndrome 2A (autosomal recessive, mild). (5236 aa)
	celsr2	Cadherin, EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2940 aa)
	lamb1b	Laminin, beta 1b. (1767 aa)
	lamb4	Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1827 aa)
	lamb2l	Laminin, beta 2-like. (1836 aa)
	lama5	Laminin, alpha 5. (3664 aa)
	creld1	Cysteine-rich with EGF-like domains 1b. (406 aa)
	lamc1	Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
	ntn1b	Netrin 1b. (602 aa)
	atrnl1b	Attractin-like 1b. (1364 aa)
	celsr1a	Cadherin EGF LAG seven-pass G-type receptor 1a; Belongs to the G-protein coupled receptor 2 family. (3044 aa)
	lama4	Laminin, alpha 4. (1871 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2CEV2_DANRE	ENSDARP00000145842	ENSDARP00000088969	ENSDARP00000145842	Si:dkey-220k22.1.	Uncharacterized protein.	0.425
E7EXX6_DANRE	LOC559501	ENSDARP00000081650	ENSDARP00000144416	Si:dkey-202e22.2.	Vav 3 guanine nucleotide exchange factor b.	0.496
E7EXX6_DANRE	lama4	ENSDARP00000081650	ENSDARP00000006065	Si:dkey-202e22.2.	Laminin, alpha 4.	0.618
E7EXX6_DANRE	lama5	ENSDARP00000081650	ENSDARP00000045125	Si:dkey-202e22.2.	Laminin, alpha 5.	0.618
E7EXX6_DANRE	lamb1a	ENSDARP00000081650	ENSDARP00000131540	Si:dkey-202e22.2.	Laminin, beta 1a.	0.540
E7EXX6_DANRE	lamb1b	ENSDARP00000081650	ENSDARP00000066944	Si:dkey-202e22.2.	Laminin, beta 1b.	0.540
E7EXX6_DANRE	lamb2	ENSDARP00000081650	ENSDARP00000123269	Si:dkey-202e22.2.	Laminin, beta 2 (laminin S).	0.540
E7EXX6_DANRE	lamb2l	ENSDARP00000081650	ENSDARP00000048365	Si:dkey-202e22.2.	Laminin, beta 2-like.	0.540
E7EXX6_DANRE	lamb4	ENSDARP00000081650	ENSDARP00000058399	Si:dkey-202e22.2.	Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.	0.540
E7EXX6_DANRE	ntn4	ENSDARP00000081650	ENSDARP00000132076	Si:dkey-202e22.2.	Netrin 4.	0.565
E7EXX6_DANRE	ntng1a	ENSDARP00000081650	ENSDARP00000157006	Si:dkey-202e22.2.	Netrin g1a.	0.735
E7EXX6_DANRE	ntng2a	ENSDARP00000081650	ENSDARP00000099713	Si:dkey-202e22.2.	Netrin g2a.	0.540
E7EXX6_DANRE	ntng2b	ENSDARP00000081650	ENSDARP00000126138	Si:dkey-202e22.2.	Netrin g2b.	0.540
ENSDARP00000145842	A2CEV2_DANRE	ENSDARP00000145842	ENSDARP00000088969	Uncharacterized protein.	Si:dkey-220k22.1.	0.425
ENSDARP00000145842	ENSDARP00000155312	ENSDARP00000145842	ENSDARP00000155312	Uncharacterized protein.	Uncharacterized protein.	0.472
ENSDARP00000145842	F1R9B8_DANRE	ENSDARP00000145842	ENSDARP00000119869	Uncharacterized protein.	Si:ch211-241e1.3.	0.494
ENSDARP00000145842	F1REG9_DANRE	ENSDARP00000145842	ENSDARP00000112621	Uncharacterized protein.	Si:ch211-158d24.2.	0.506
ENSDARP00000145842	lama1	ENSDARP00000145842	ENSDARP00000135371	Uncharacterized protein.	Laminin, alpha 1.	0.472
ENSDARP00000145842	lama2	ENSDARP00000145842	ENSDARP00000131993	Uncharacterized protein.	Laminin, alpha 2.	0.573
ENSDARP00000145842	lama3	ENSDARP00000145842	ENSDARP00000150169	Uncharacterized protein.	Laminin, alpha 3.	0.494

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