(15 nodes) This domain is found in eukaryotes. This domain is typically between 135 and 149 amino acids in length and is found associated with the CH domain. network (Danio rerio)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

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Others

textmining

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Your Input:
	mical3a	Protein-methionine sulfoxide oxidase mical3a; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family. (1994 aa)
	micall2a	Mical-like 2a. (799 aa)
	pik3r6a	Phosphoinositide-3-kinase, regulatory subunit 6a. (192 aa)
	ehbp1	EH domain-binding protein 1. (1183 aa)
	mical3b	Protein-methionine sulfoxide oxidase mical3b; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family. (1673 aa)
	mical1	[F-actin]-monooxygenase mical1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization; Belongs to the Mical family. (1227 aa)
	mical2b	Protein-methionine sulfoxide oxidase mical2b; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrt [...] (1679 aa)
	micall2b	Mical-like 2b. (783 aa)
	ehbp1l1a	EH domain-binding protein 1-like 1a. (4318 aa)
	mical3a-2	Protein-methionine sulfoxide oxidase mical3a. (1017 aa)
	micall1b.2	MICAL-like 1b, duplicate 2. (686 aa)
	BMERB1	Zgc:114175. (184 aa)
	micall1a	MICAL-like 1a. (867 aa)
	ehbp1l1b	EH domain-binding protein 1-like 1b. (2382 aa)
	zgc:171844	Zgc:171844 protein. (194 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ehbp1	ehbp1l1a	ENSDARP00000127979	ENSDARP00000142897	EH domain-binding protein 1.	EH domain-binding protein 1-like 1a.	0.540
ehbp1	ehbp1l1b	ENSDARP00000127979	ENSDARP00000083638	EH domain-binding protein 1.	EH domain-binding protein 1-like 1b.	0.540
ehbp1l1a	ehbp1	ENSDARP00000142897	ENSDARP00000127979	EH domain-binding protein 1-like 1a.	EH domain-binding protein 1.	0.540
ehbp1l1a	ehbp1l1b	ENSDARP00000142897	ENSDARP00000083638	EH domain-binding protein 1-like 1a.	EH domain-binding protein 1-like 1b.	0.540
ehbp1l1b	ehbp1	ENSDARP00000083638	ENSDARP00000127979	EH domain-binding protein 1-like 1b.	EH domain-binding protein 1.	0.540
ehbp1l1b	ehbp1l1a	ENSDARP00000083638	ENSDARP00000142897	EH domain-binding protein 1-like 1b.	EH domain-binding protein 1-like 1a.	0.540
micall2a	micall2b	ENSDARP00000135432	ENSDARP00000118632	Mical-like 2a.	Mical-like 2b.	0.919
micall2b	micall2a	ENSDARP00000118632	ENSDARP00000135432	Mical-like 2b.	Mical-like 2a.	0.919

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