(17 nodes) Nuclear receptors in lipid metabolism and toxicity network (Danio rerio)

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Known Interactions

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Your Input:
	cyp26a1	Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
	abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2. (1553 aa)
	pparg	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
	cyp27b1	Cytochrome P450, family 27, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (506 aa)
	rargb	Retinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (392 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (441 aa)
	abcd3a	ATP-binding cassette, sub-family D (ALD), member 3a. (656 aa)
	cyp3a65	Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family. (517 aa)
	cyp24a1	Cytochrome P450, family 24, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family. (505 aa)
	cyp4t8	Cytochrome P450, family 4, subfamily T, polypeptide 8. (458 aa)
	cyp7a1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	abcb11b	ATP-binding cassette, sub-family B (MDR/TAP), member 11b. (1308 aa)
	nr1i2	Nuclear receptor subfamily 1, group I, member 2. (430 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (483 aa)
	rarga	Retinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
abcb11b	abcc2	ENSDARP00000093333	ENSDARP00000025026	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	0.419
abcb11b	abcg5	ENSDARP00000093333	ENSDARP00000086278	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.450
abcb11b	cyp7a1	ENSDARP00000093333	ENSDARP00000113850	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.775
abcb11b	nr1h4	ENSDARP00000093333	ENSDARP00000061793	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Nuclear receptor subfamily 1, group H, member 4.	0.862
abcb11b	nr1i2	ENSDARP00000093333	ENSDARP00000106185	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	Nuclear receptor subfamily 1, group I, member 2.	0.439
abcc2	abcb11b	ENSDARP00000025026	ENSDARP00000093333	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	0.419
abcc2	abcg5	ENSDARP00000025026	ENSDARP00000086278	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.494
abcc2	cyp3a65	ENSDARP00000025026	ENSDARP00000137034	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	Cytochrome P450, family 3, subfamily A, polypeptide 65; Belongs to the cytochrome P450 family.	0.543
abcc2	nr1h4	ENSDARP00000025026	ENSDARP00000061793	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	Nuclear receptor subfamily 1, group H, member 4.	0.566
abcc2	nr1i2	ENSDARP00000025026	ENSDARP00000106185	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	Nuclear receptor subfamily 1, group I, member 2.	0.553
abcg1	abcg5	ENSDARP00000087241	ENSDARP00000086278	ATP-binding cassette, sub-family G (WHITE), member 1.	ATP-binding cassette, sub-family G (WHITE), member 5.	0.690
abcg1	cyp7a1	ENSDARP00000087241	ENSDARP00000113850	ATP-binding cassette, sub-family G (WHITE), member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.587
abcg1	nr1h3	ENSDARP00000087241	ENSDARP00000139970	ATP-binding cassette, sub-family G (WHITE), member 1.	Nuclear receptor subfamily 1, group H, member 3.	0.868
abcg1	pparg	ENSDARP00000087241	ENSDARP00000142487	ATP-binding cassette, sub-family G (WHITE), member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.478
abcg5	abcb11b	ENSDARP00000086278	ENSDARP00000093333	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family B (MDR/TAP), member 11b.	0.450
abcg5	abcc2	ENSDARP00000086278	ENSDARP00000025026	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family C (CFTR/MRP), member 2.	0.494
abcg5	abcg1	ENSDARP00000086278	ENSDARP00000087241	ATP-binding cassette, sub-family G (WHITE), member 5.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.690
abcg5	cyp7a1	ENSDARP00000086278	ENSDARP00000113850	ATP-binding cassette, sub-family G (WHITE), member 5.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.777
abcg5	nr1h3	ENSDARP00000086278	ENSDARP00000139970	ATP-binding cassette, sub-family G (WHITE), member 5.	Nuclear receptor subfamily 1, group H, member 3.	0.739
abcg5	nr1h4	ENSDARP00000086278	ENSDARP00000061793	ATP-binding cassette, sub-family G (WHITE), member 5.	Nuclear receptor subfamily 1, group H, member 4.	0.681

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