STRINGSTRING
wnt1 wnt1 serpine1 serpine1 fas fas epas1b epas1b rxraa rxraa zmpste24 zmpste24 gata2a gata2a ptgis ptgis bmp3 bmp3 srebf1 srebf1 wwtr1 wwtr1 mbnl1 mbnl1 dvl1b dvl1b stat3 stat3 mif mif borcs8 borcs8 klf7a klf7a roraa roraa ncoa2 ncoa2 klf15 klf15 bmp2b bmp2b lpl lpl ppardb ppardb sp1 sp1 plin2 plin2 lepa lepa ncoa1 ncoa1 cebpd cebpd cdkn1a cdkn1a lpin2 lpin2 cntfr cntfr mef2d mef2d nr2f1a nr2f1a mef2aa mef2aa gdf10a gdf10a ncor1 ncor1 bscl2 bscl2 pparab pparab lpin1 lpin1 agpat2 agpat2 e2f4 e2f4 il6st il6st wnt5b wnt5b foxo1a foxo1a gata4 gata4 gadd45ab gadd45ab ctnnb1 ctnnb1 mef2cb mef2cb ebf1a ebf1a nr1h3 nr1h3 adipoqb adipoqb pparg pparg scdb scdb bmp1a bmp1a lmna lmna hif1ab hif1ab pck2 pck2 hnf1a hnf1a klf5a klf5a stat1a stat1a igf1 igf1 gata3 gata3 agt agt pck1 pck1 rb1 rb1 frzb frzb gadd45ba gadd45ba ahr1b ahr1b trib3 trib3 klf6a klf6a celf1 celf1 cyp26a1 cyp26a1 smad3b smad3b gtf3aa gtf3aa stat2 stat2 ncor2 ncor2 ins ins cebpa cebpa nr3c1 nr3c1 socs1a socs1a gh1 gh1 cfd cfd wnt10b wnt10b tgfb1a tgfb1a cebpb cebpb egr2b egr2b rbl1 rbl1 bmp4 bmp4 creb1a creb1a irs1 irs1 id3 id3 cyp26c1 cyp26c1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wnt1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
fasFas cell surface death receptor. (293 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
rxraaRetinoic acid receptor RXR-alpha-A; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimer [...] (458 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
gata2aGATA-binding protein 2a. (456 aa)
ptgisProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). (480 aa)
bmp3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (452 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
wwtr1WW domain-containing transcription regulator 1. (391 aa)
mbnl1Muscleblind-like-splicing regulator 1. (424 aa)
dvl1bDishevelled segment polarity protein 1b. (716 aa)
stat3Signal transducer and activator of transcription. (806 aa)
mifMacrophage migration inhibitory factor. (115 aa)
borcs8BLOC-1-related complex subunit 8; As part of a BORC-like complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, this complex may couple lysosomes to microtubule plus-end-directed kinesin motor. Belongs to the BORCS8 family. (124 aa)
klf7aKruppel-like factor 7a. (286 aa)
roraaNuclear receptor ROR-alpha A; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity). Required for proper cerebellum development. (468 aa)
ncoa2Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity). (1505 aa)
klf15Krueppel-like factor 15. (442 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
lplLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (511 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
sp1Sp1 transcription factor. (594 aa)
plin2Perilipin; Belongs to the perilipin family. (444 aa)
lepaPutative leptin. (166 aa)
ncoa1Nuclear receptor coactivator 1. (1349 aa)
cebpdCCAAT/enhancer-binding protein. (280 aa)
cdkn1aCyclin-dependent kinase inhibitor 1A. (154 aa)
lpin2Lipin 2. (905 aa)
cntfrCiliary neurotrophic factor receptor. (357 aa)
mef2dMyocyte enhancer factor 2d. (529 aa)
nr2f1aNuclear receptor subfamily 2 group F member 1-A; Putative transcription factor that is required in photoreceptor cells precursors during eye development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (411 aa)
mef2aaMyocyte enhancer factor 2aa. (458 aa)
gdf10aGrowth differentiation factor 10a. (441 aa)
ncor1Nuclear receptor corepressor 1. (2398 aa)
bscl2BSCL2 lipid droplet biogenesis-associated, seipin. (386 aa)
pparabPeroxisome proliferator-activated receptor alpha b. (459 aa)
lpin1Lipin 1. (920 aa)
agpat21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (271 aa)
e2f4E2F transcription factor 4. (404 aa)
il6stInterleukin 6 signal transducer. (866 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
gata4GATA-binding protein 4. (352 aa)
gadd45abGrowth arrest and DNA-damage-inducible, alpha, b. (156 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
mef2cbMyocyte enhancer factor 2cb. (483 aa)
ebf1aTranscription factor COE1-A; Transcriptional activator; Belongs to the COE family. (611 aa)
nr1h3Nuclear receptor subfamily 1, group H, member 3. (441 aa)
adipoqbAdiponectin, C1Q and collagen domain-containing, b. (299 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
scdbStearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. (316 aa)
bmp1aMetalloendopeptidase. (986 aa)
lmnaLamin A; Belongs to the intermediate filament family. (675 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
pck2Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (636 aa)
hnf1aHNF1 homeobox a. (560 aa)
klf5aProgesterone immunomodulatory-binding factor 1. (429 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
igf1Insulin-like growth factor 1b. (161 aa)
gata3Transcription factor GATA-3. (438 aa)
agtAngiotensinogen; Belongs to the serpin family. (454 aa)
pck1Phosphoenolpyruvate carboxykinase 1 (soluble). (630 aa)
rb1Retinoblastoma 1. (903 aa)
frzbFrizzled-related protein. (315 aa)
gadd45baGrowth arrest and DNA-damage-inducible, beta a. (159 aa)
ahr1bAryl hydrocarbon receptor 1B. (940 aa)
trib3Tribbles pseudokinase 3. (348 aa)
klf6aKruppel-like factor 6a. (283 aa)
celf1CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon; Belongs to the CELF/BRUNOL family. (534 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
smad3bMothers against decapentaplegic homolog. (423 aa)
gtf3aaGeneral transcription factor IIIAa. (367 aa)
stat2Signal transducer and activator of transcription. (836 aa)
ncor2Nuclear receptor corepressor 2. (2315 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
cebpaCCAAT/enhancer-binding protein. (288 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
socs1aSuppressor of cytokine-signaling 1a. (201 aa)
gh1Growth hormone 1. (210 aa)
cfdComplement factor D (adipsin); Belongs to the peptidase S1 family. (249 aa)
wnt10bProtein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer. (427 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
cebpbCCAAT/enhancer-binding protein. (280 aa)
egr2bEarly growth response protein 2b; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. (412 aa)
rbl1Retinoblastoma-like 1 (p107). (1058 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
creb1acAMP-responsive element-binding protein 1a. (318 aa)
irs1Insulin receptor substrate 1. (1099 aa)
id3Inhibitor of DNA binding 3. (116 aa)
cyp26c1Cytochrome P450, family 26, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (554 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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