STRINGSTRING
nkd1 nkd1 csnk1da csnk1da prkci prkci wnt10a wnt10a map3k7 map3k7 gpc4 gpc4 fbxw2 fbxw2 fosl1a fosl1a ppp2r1bb ppp2r1bb nkd2a nkd2a racgap1 racgap1 dvl2 dvl2 gsk3ba gsk3ba prkcha prkcha fzd5 fzd5 prkcbb prkcbb pafah1b1b pafah1b1b wnt2bb wnt2bb prkcq prkcq ldlra ldlra wnt9b wnt9b wnt10b wnt10b prkcz prkcz jun jun wnt7aa wnt7aa ccnd2a ccnd2a fzd2 fzd2 wnt1 wnt1 fzd3a fzd3a wnt3a wnt3a wnt11 wnt11 ppp2r5eb ppp2r5eb wnt2ba wnt2ba dvl1b dvl1b sox2 sox2 wnt4 wnt4 prkcea prkcea zbtb33 zbtb33 mapk9 mapk9 ppp2r5cb ppp2r5cb ppp2r3b ppp2r3b wnt6b wnt6b wnt3 wnt3 lrp5 lrp5 ppp2r3a ppp2r3a lef1 lef1 tp53 tp53 ppp2r2ab ppp2r2ab ptpa ptpa wnt16 wnt16 zgc:56064 zgc:56064 cd44b cd44b wnt7bb wnt7bb prkd1 prkd1 CTBP1 CTBP1 ppp2r2bb ppp2r2bb axin2 axin2 wnt5b wnt5b foxj1a foxj1a mapk10 mapk10 lrp6 lrp6 axin1 axin1 wnt5a wnt5a ctnnb1 ctnnb1 apc apc ppp2cb ppp2cb fzd6 fzd6 ccnd1 ccnd1 dvl3 dvl3 fzd1 fzd1 prkcaa prkcaa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nkd1Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family. (440 aa)
csnk1daCasein kinase I isoform delta-A; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity). (403 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
wnt10aProtein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development. Regulates the expression of genes involved in tooth development. Belongs to the Wnt family. (442 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (551 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
fbxw2F-box and WD repeat domain-containing 2. (455 aa)
fosl1aFOS-like 1, AP-1 transcription factor subunit a. (346 aa)
ppp2r1bbProtein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform. (589 aa)
nkd2aProtein naked cuticle homolog 2-like; Cell autonomous antagonist of both the canonical and non- canonical Wnt signaling pathways; Belongs to the NKD family. (409 aa)
racgap1Rac GTPase-activating protein 1. (654 aa)
dvl2Dishevelled segment polarity protein 2. (747 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
prkchaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (712 aa)
fzd5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa)
prkcbbProtein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa)
pafah1b1bLissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
prkcqProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (713 aa)
ldlraLow density lipoprotein receptor a. (911 aa)
wnt9bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
wnt10bProtein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer. (427 aa)
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
wnt7aaProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ccnd2aCyclin D2, a; Belongs to the cyclin family. (298 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
wnt1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa)
fzd3aTransmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (685 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ppp2r5ebSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
dvl1bDishevelled segment polarity protein 1b. (716 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
wnt4Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa)
prkceaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (744 aa)
zbtb33Zinc finger and BTB domain-containing 33. (624 aa)
mapk9Mitogen-activated protein kinase. (421 aa)
ppp2r5cbSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (578 aa)
ppp2r3bProtein phosphatase 2, regulatory subunit B'', beta. (583 aa)
wnt6bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
wnt3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (520 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
ppp2r2abSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
ptpaSerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (324 aa)
wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
zgc:56064Serine/threonine-protein phosphatase. (309 aa)
cd44bCD44 molecule (Indian blood group) b. (405 aa)
wnt7bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
prkd1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (886 aa)
CTBP1Zgc:136929; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (440 aa)
ppp2r2bbSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
axin2Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
foxj1aForkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia. (458 aa)
mapk10Mitogen-activated protein kinase. (472 aa)
lrp6Low density lipoprotein receptor-related protein 6. (935 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (617 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
dvl3Dishevelled segment polarity protein 3b. (706 aa)
fzd1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
prkcaaProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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