STRINGSTRING
tradd tradd apaf1 apaf1 casp23 casp23 tnfb tnfb tnfrsf1a tnfrsf1a chuk chuk ripk1l ripk1l nfkbiab nfkbiab igf2a igf2a igf1ra igf1ra dffb dffb igf1 igf1 xiap xiap ikbkg ikbkg bcl2l1 bcl2l1 tnfrsf21 tnfrsf21 bnip3la bnip3la traf3 traf3 cradd cradd nfkbib nfkbib casp9 casp9 casp6a casp6a casp2 casp2 tp73 tp73 E7FDJ7_DANRE E7FDJ7_DANRE bada bada irf2a irf2a tp53 tp53 ikbkb ikbkb irf4b irf4b bcl2a bcl2a boka boka prf1.2 prf1.2 irf3 irf3 rela rela mapk10 mapk10 nfkb1 nfkb1 irf5 irf5 faslg faslg map3k1 map3k1 irf6 irf6 fadd fadd irf1b irf1b diabloa diabloa cdkn2a/b cdkn2a/b pik3r1 pik3r1 jun jun tp63 tp63 scaf11 scaf11 casp3b casp3b mdm2 mdm2 dffa dffa cflara cflara gzm3.2 gzm3.2 fas fas tnfsf10 tnfsf10 hells hells nfkbie nfkbie traf1 traf1 irf7 irf7 mcl1a mcl1a myca myca birc5a birc5a birc2 birc2 tnfrsf1b tnfrsf1b LOC100534669 LOC100534669 map2k4a map2k4a tnfrsfa tnfrsfa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)
apaf1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa)
casp23Caspase 23, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (446 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
tnfrsf1aTumor necrosis factor receptor superfamily, member 1a. (389 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
ripk1lReceptor (TNFRSF)-interacting serine-threonine kinase 1,-like. (661 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
igf1raTyrosine-protein kinase receptor. (1405 aa)
dffbDNA fragmentation factor, beta polypeptide (caspase-activated DNase). (333 aa)
igf1Insulin-like growth factor 1b. (161 aa)
xiapX-linked inhibitor of apoptosis. (405 aa)
ikbkgInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (586 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
tnfrsf21Tumor necrosis factor receptor superfamily, member 21. (637 aa)
bnip3laBCL2/adenovirus E1B interacting protein 3-like, 2. (233 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
craddCASP2 and RIPK1 domain-containing adaptor with death domain. (200 aa)
nfkbibNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta. (394 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
casp6aCaspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (298 aa)
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (399 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa)
E7FDJ7_DANRESi:ch211-112c15.8. (373 aa)
badaBCL2-associated agonist of cell death a. (145 aa)
irf2aInterferon regulatory factor. (341 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
irf4bInterferon regulatory factor 4b. (431 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
bokaBcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. (224 aa)
prf1.2Perforin 1.2. (574 aa)
irf3Interferon regulatory factor 3. (426 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
mapk10Mitogen-activated protein kinase. (472 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
irf5Interferon regulatory factor 5. (516 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
map3k1Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase. (1334 aa)
irf6Interferon regulatory factor 6. (492 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
irf1bInterferon regulatory factor. (287 aa)
diabloaDiablo, IAP-binding mitochondrial protein a. (265 aa)
cdkn2a/bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (129 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
tp63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (588 aa)
scaf11SR-related CTD-associated factor 11. (1321 aa)
casp3bCaspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (285 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. (475 aa)
dffaDNA fragmentation factor, alpha polypeptide. (305 aa)
cflaraCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa)
gzm3.2Granzyme 3, tandem duplicate 2. (249 aa)
fasFas cell surface death receptor. (293 aa)
tnfsf10Tumor necrosis factor (Ligand) superfamily, member 10 like 2; Belongs to the tumor necrosis factor family. (299 aa)
hellsHelicase, lymphoid-specific. (853 aa)
nfkbieNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (343 aa)
traf1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (551 aa)
irf7Interferon regulatory factor 7. (422 aa)
mcl1aMCL1 apoptosis regulator, BCL2 family member a. (255 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
birc5aBaculoviral IAP repeat-containing 5a. (190 aa)
birc2Baculoviral IAP repeat-containing 2. (647 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
LOC100534669Uncharacterized protein. (166 aa)
map2k4aMitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa)
tnfrsfaTumor necrosis factor receptor superfamily, member a. (436 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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