STRINGSTRING
map2k7 map2k7 pik3cg pik3cg map3k7 map3k7 map2k1 map2k1 tnfb tnfb mapk12a mapk12a chuk chuk ripk1l ripk1l tlr3 tlr3 stat1a stat1a pik3cd pik3cd tab2 tab2 myd88 myd88 akt2 akt2 tnfa tnfa ikbkg ikbkg mapk11 mapk11 traf6 traf6 mapk1 mapk1 traf3 traf3 pik3r3b pik3r3b mapk14a mapk14a frmpd4 frmpd4 tirap tirap lepb lepb cd40 cd40 ikbkb ikbkb irak1 irak1 nfkb2 nfkb2 tlr5a tlr5a tlr5b tlr5b map2k2b map2k2b irf3 irf3 pik3cb pik3cb il12a il12a ticam1 ticam1 pik3r2 pik3r2 tbk1 tbk1 rela rela mapk10 mapk10 irak4 irak4 nfkb1 nfkb1 irf5 irf5 pik3ca pik3ca tlr1 tlr1 akt3a akt3a fadd fadd il1b il1b tollip tollip map2k6 map2k6 mapk8a mapk8a tlr9 tlr9 fosab fosab tlr2 tlr2 pik3r1 pik3r1 jun jun ikbke ikbke mapk13 mapk13 map3k8 map3k8 spp1 spp1 irf7 irf7 mapk3 mapk3 casp8 casp8 rac1a rac1a mapk9 mapk9 map2k4b map2k4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
map2k7Mitogen-activated protein kinase kinase 7. (438 aa)
pik3cgPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1098 aa)
map3k7Mitogen-activated protein kinase kinase kinase 7. (551 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
mapk12aMitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAP [...] (363 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
ripk1lReceptor (TNFRSF)-interacting serine-threonine kinase 1,-like. (661 aa)
tlr3Toll-like receptor 3; Belongs to the Toll-like receptor family. (903 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
tab2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; May play a role in signaling pathway. Involved in heart development. (711 aa)
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
akt2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
ikbkgInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (586 aa)
mapk11Mitogen-activated protein kinase. (361 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
pik3r3bPhosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (P55, gamma). (464 aa)
mapk14aMitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa)
frmpd4Toll-like receptor 7. (1221 aa)
tirapToll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (203 aa)
lepbLeptin b. (119 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
irak1Interleukin-1 receptor-associated kinase 1. (686 aa)
nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (902 aa)
tlr5aToll-like receptor 5a; Belongs to the Toll-like receptor family. (881 aa)
tlr5bToll-like receptor 5b; Belongs to the Toll-like receptor family. (881 aa)
map2k2bMitogen-activated protein kinase kinase 2b; Belongs to the protein kinase superfamily. (395 aa)
irf3Interferon regulatory factor 3. (426 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa)
il12aInterleukin 12a. (196 aa)
ticam1Toll-like receptor adaptor molecule 1. (566 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
tbk1TANK-binding kinase 1. (727 aa)
relaV-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
mapk10Mitogen-activated protein kinase. (472 aa)
irak4Interleukin-1 receptor-associated kinase 4. (447 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
irf5Interferon regulatory factor 5. (516 aa)
pik3caPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
tlr1Toll-like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
akt3aNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
il1bInterleukin-1. (284 aa)
tollipToll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (276 aa)
map2k6Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] (363 aa)
mapk8aMitogen-activated protein kinase. (427 aa)
tlr9Toll-like receptor 9; Belongs to the Toll-like receptor family. (1069 aa)
fosabV-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa)
tlr2Toll-like receptor 2. (788 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
ikbkeInhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
mapk13Mitogen-activated protein kinase. (362 aa)
map3k8Mitogen-activated protein kinase kinase kinase 8. (472 aa)
spp1Secreted phosphoprotein 1. (305 aa)
irf7Interferon regulatory factor 7. (422 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
rac1aRas-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa)
mapk9Mitogen-activated protein kinase. (421 aa)
map2k4bMitogen-activated protein kinase kinase 4B; Belongs to the protein kinase superfamily. (417 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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