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| | fgf13b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (257 aa) |
| | egr2a | Early growth response 2a. (393 aa) |
| | badb | BCL2-associated agonist of cell death b. (147 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | creb1a | cAMP-responsive element-binding protein 1a. (318 aa) |
| | bmp4 | Bone morphogenetic protein 4. (400 aa) |
| | fgf23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (258 aa) |
| | etv5b | ETS variant transcription factor 5b. (524 aa) |
| | fgf18b | Fibroblast growth factor 18b; Belongs to the heparin-binding growth factors family. (213 aa) |
| | egr2b | Early growth response protein 2b; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. (412 aa) |
| | ptpn1 | Protein tyrosine phosphatase non-receptor type 1. (350 aa) |
| | fgf16 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa) |
| | fgf14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa) |
| | snai2 | Snail homolog 2 (Drosophila). (257 aa) |
| | fgf8b | Fibroblast growth factor 8b; May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system. (212 aa) |
| | nras | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa) |
| | fgf24 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | egr1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa) |
| | spry2 | Sprouty RTK-signaling antagonist 2. (301 aa) |
| | eef2k | Eukaryotic elongation factor 2 kinase. (706 aa) |
| | rps6ka3a | Ribosomal protein S6 kinase. (732 aa) |
| | sh3glb2a | SH3-domain GRB2-like endophilin B2a. (381 aa) |
| | fgf5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa) |
| | fgf10a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa) |
| | braf | B-Raf proto-oncogene, serine/threonine kinase. (817 aa) |
| | sh3glb1b | SH3-domain GRB2-like endophilin B1b. (360 aa) |
| | etv2 | ETS variant transcription factor 2. (366 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | fosab | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa) |
| | nr2f5 | Nuclear receptor subfamily 2 group F member 5; Putative receptor that is required in photoreceptor cells precursors during eye development; Belongs to the nuclear hormone receptor family. NR2 subfamily. (403 aa) |
| | mapk14a | Mitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa) |
| | mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa) |
| | mapk14b | Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa) |
| | ets1 | V-ets avian erythroblastosis virus E26 oncogene homolog 1. (266 aa) |
| | cbl | Cbl proto-oncogene, E3 ubiquitin protein ligase. (913 aa) |
| | atf3 | Activating transcription factor 3. (202 aa) |
| | mycn | N-myc protein; May function as a transcription factor. (503 aa) |
| | gata5 | Transcription factor gata5. (383 aa) |
| | fgf13a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa) |
| | eif4e1b | Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein. (214 aa) |
| | zgc:55558 | Zgc:55558 protein. (187 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | mapkapk2a | Mitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily. (382 aa) |
| | mknk2b | MAPK-interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | etv4 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa) |
| | map2k2a | Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | mapk8b | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa) |
| | fgfr3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa) |
| | mapk12a | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAP [...] (363 aa) |
| | fgf6a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa) |
| | usf1l | Upstream transcription factor 2, c-fos interacting. (283 aa) |
| | fgf1a | Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa) |
| | sp8a | Sp8 transcription factor a. (406 aa) |
| | map2k1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa) |
| | sh3gl3b | SH3-domain GRB2-like 3b. (386 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | sp8b | Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Belongs to the Sp1 C2H2-type zinc-finger protein family. (455 aa) |
| | gbx2 | Gastrulation brain homeo box 2. (342 aa) |
| | fgfr1op2 | FGFR1 oncogene partner 2 homolog. (215 aa) |
| | atf7a | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (497 aa) |
| | map3k7 | Mitogen-activated protein kinase kinase kinase 7. (551 aa) |
| | fgf20a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | gemin2 | Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family. (261 aa) |
| | map2k6 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] (363 aa) |
| | sos1 | Son of sevenless homolog 1 (Drosophila). (714 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | sp9 | Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. (439 aa) |
| | il17rd | Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. (743 aa) |
| | fgf10b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa) |
| | fgfrl1b | Fibroblast growth factor receptor-like 1b. (481 aa) |
| | sox32 | SRY-box transcription factor 32. (307 aa) |
| | fgf17 | Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family. (215 aa) |
| | dusp1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa) |
| | shcbp1 | SHC SH2-domain-binding protein 1. (721 aa) |
| | cdh1 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa) |
| | fgf19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | sox17 | SRY-box transcription factor 17. (413 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | creb1b | cAMP-responsive element-binding protein 1b. (324 aa) |
| | rps6kal | Ribosomal protein S6 kinase alpha-6; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (740 aa) |
| | fgfr2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa) |
| | grb2b | Growth factor receptor-bound protein 2b. (217 aa) |
| | fgf7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa) |
| | plcg1 | Phosphoinositide phospholipase C. (1020 aa) |
| | mapk7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1080 aa) |
| | araf | A-Raf proto-oncogene, serine/threonine kinase. (604 aa) |
| | fgf11a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa) |
| | frs2b | Fibroblast growth factor receptor substrate 2b. (508 aa) |
| | sh3glb2b | SH3-domain GRB2-like endophilin B2b. (402 aa) |
| | tbx16l | T-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa) |
| | mapkapk5 | Mitogen-activated protein kinase-activated protein kinase 5. (471 aa) |
| | pcdh8 | Protocadherin 8. (950 aa) |
| | snai1a | Snail family zinc finger 1a. (260 aa) |
| | sp1 | Sp1 transcription factor. (594 aa) |
| | junba | JunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa) |
| | fgf20b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | fgf18a | Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa) |
| | map2k4a | Mitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa) |
| | eif4ea | Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. (215 aa) |
| | gbx1 | Gastrulation brain homeobox 1. (316 aa) |
| | dusp6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa) |
| | mapk3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa) |
| | elk4 | ETS transcription factor ELK4. (443 aa) |
| | sh3gl1b | SH3-domain GRB2-like 1b. (351 aa) |
| | pla2g4aa | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (741 aa) |
| | spry4 | Sprouty homolog 4 (Drosophila). (310 aa) |
| | sh3gl2a | SH3 domain-containing GRB2-like 2a, endophilin A1. (347 aa) |
| | rasgrf2b | Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP. May function in synaptic plasticity. (1244 aa) |
| | fgfrl1a | Fibroblast growth factor receptor-like 1a. (483 aa) |
| | raf1b | Raf-1 proto-oncogene, serine/threonine kinase b. (629 aa) |
| | gsc | Homeobox protein goosecoid. (240 aa) |
| | ptpn11a | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa) |
| | rps6kb1b | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (502 aa) |
