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| | rhocb | Rho-related GTP-binding protein RhoA-D; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | cyb5r1 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (304 aa) |
| | wnt10a | Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Required for normal tooth development. Regulates the expression of genes involved in tooth development. Belongs to the Wnt family. (442 aa) |
| | map3k7 | Mitogen-activated protein kinase kinase kinase 7. (551 aa) |
| | fzd9b | Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa) |
| | cfl2 | Cofilin 2 (Muscle); Belongs to the actin-binding proteins ADF family. (166 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | tcf7l2 | Transcription factor 7-like 2 (T-cell specific, HMG-box). (477 aa) |
| | yes1 | Tyrosine-protein kinase yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak. (546 aa) |
| | tcf3a | Transcription factor 3a. (570 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | mapk8b | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | etv4 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | wif1 | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. (378 aa) |
| | cap1 | Adenylyl cyclase-associated protein; Belongs to the CAP family. (463 aa) |
| | lhx1a | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | cfl1 | Muscle cofilin 2; Belongs to the actin-binding proteins ADF family. (165 aa) |
| | efnb1 | Ephrin-B1; Belongs to the ephrin family. (341 aa) |
| | frzb | Frizzled-related protein. (315 aa) |
| | gsna | Gelsolin a. (729 aa) |
| | gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) |
| | vangl1 | Vang-like protein. (527 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | fzd5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (592 aa) |
| | fzd7b | Frizzled class receptor 7b; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa) |
| | mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa) |
| | prkcbb | Protein kinase C beta type; Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome, apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell survival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of card11/carma1, leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative [...] (670 aa) |
| | rhoaa | Rho-related GTP-binding protein RhoA-A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) |
| | tdgf1 | Teratocarcinoma-derived growth factor 1. (190 aa) |
| | celsr1a | Cadherin EGF LAG seven-pass G-type receptor 1a; Belongs to the G-protein coupled receptor 2 family. (3044 aa) |
| | camk2d2 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system. (554 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | tle3a | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | sfrp1a | Secreted frizzled-related protein 1a. (296 aa) |
| | capga | Capping protein (actin filament), gelsolin-like a. (350 aa) |
| | evla | Enah/Vasp-like a. (387 aa) |
| | spry2 | Sprouty RTK-signaling antagonist 2. (301 aa) |
| | pfn2l | Profilin; Belongs to the profilin family. (139 aa) |
| | has2 | Hyaluronan synthase 2. (552 aa) |
| | fzd8b | Frizzled class receptor 8b; Belongs to the G-protein coupled receptor Fz/Smo family. (576 aa) |
| | mitfa | Microphthalmia-associated transcription factor a. (412 aa) |
| | ctnnbip1 | Catenin, beta-interacting protein 1. (81 aa) |
| | sfrp5 | Secreted frizzled-related protein 5. (310 aa) |
| | gbp | Glycogen synthase kinase-binding protein. (149 aa) |
| | cdc42l | Cell division cycle 42,-like. (191 aa) |
| | prickle1a | Prickle homolog 1a. (793 aa) |
| | inhbb | Inhibin subunit beta B. (393 aa) |
| | wnt10b | Protein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Involved in neurogenesis. Performs a partially redundant function with wnt1 in the formation of the midbrain-hindbrain boundary (MHB) organizer. (427 aa) |
| | dharma | Dharma. (192 aa) |
| | wnt2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). (350 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | otx1 | Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa) |
| | etv5b | ETS variant transcription factor 5b. (524 aa) |
| | camk1ga | Calcium/calmodulin-dependent protein kinase IGa; Belongs to the protein kinase superfamily. (426 aa) |
| | wnt7aa | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | fzd8a | Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa) |
| | actr2a | Actin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa) |
| | bmp4 | Bone morphogenetic protein 4. (400 aa) |
| | fzd2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa) |
| | wnt1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa) |
| | eve1 | Even-skipped-like1. (224 aa) |
| | ptpn11a | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa) |
| | ctnnb2 | Catenin, beta 2. (778 aa) |
| | gsc | Homeobox protein goosecoid. (240 aa) |
| | gata2a | GATA-binding protein 2a. (456 aa) |
| | dact2 | Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Positive regulator of the Wnt signaling pathway which acts downstream of wnt1 indicative for non- canonical Wnt signaling. Also negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. Required for convergent extension movements in gastrulation. (837 aa) |
| | rhoca | Ras homolog gene family, member Ae. (193 aa) |
| | limk2 | LIM domain kinase 2. (651 aa) |
| | dvl3a | Dishevelled segment polarity protein 3a. (676 aa) |
| | csk | Tyrosine-protein kinase. (450 aa) |
| | wnt3a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | fzd10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | spry4 | Sprouty homolog 4 (Drosophila). (310 aa) |
| | wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | actr2b | Actin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa) |
| | src | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa) |
| | sp5a | Sp5 transcription factor a. (368 aa) |
| | wnt2ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa) |
| | mapk3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa) |
| | tmsb4x | Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa) |
| | dusp6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | pfn2 | Profilin; Belongs to the profilin family. (140 aa) |
| | wnt4 | Protein Wnt-4a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development. (352 aa) |
| | rac1a | Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1). (192 aa) |
| | mapk9 | Mitogen-activated protein kinase. (421 aa) |
| | myca | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa) |
| | nlk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (475 aa) |
| | actr3 | Actin-related protein 3; Belongs to the actin family. (231 aa) |
| | celsr1b | Cadherin EGF LAG seven-pass G-type receptor 1b; Belongs to the G-protein coupled receptor 2 family. (3006 aa) |
| | rac1b | Ras-related C3 botulinum toxin substrate 1-like protein. (192 aa) |
| | fzd7a | Frizzled class receptor 7a; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa) |
| | rac2 | Rac family small GTPase 2. (219 aa) |
| | bmp2b | Bone morphogenetic protein 2b. (411 aa) |
| | otx2b | Homeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. (289 aa) |
| | rac3a | Ras-related C3 botulinum toxin substrate 3 (Rho family, small GTP binding protein Rac3). (192 aa) |
| | tbx16l | T-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | wnt8a | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa) |
| | abi1a | Abl-interactor 1a. (483 aa) |
| | rock2a | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1375 aa) |
| | cdc42l2 | Cell division cycle 42-like 2. (209 aa) |
| | fyna | Tyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. (537 aa) |
| | Rac1l | Si:ch211-1f22.1. (192 aa) |
| | quo | Quattro. (1991 aa) |
| | cdc42 | Cell division cycle 42. (191 aa) |
| | vent | Ventral-expressed homeobox. (170 aa) |
| | vox | Ventral homeobox. (242 aa) |
| | pak1 | Non-specific serine/threonine protein kinase. (587 aa) |
| | axin2 | Axin-2; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning by down-regulating ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos. (812 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | limk1a | LIM domain kinase 1a. (648 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | mapk10 | Mitogen-activated protein kinase. (472 aa) |
| | axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) |
| | prickle2b | Prickle homolog 2b. (840 aa) |
| | capgb | Capping protein (actin filament), gelsolin-like b. (345 aa) |
| | wnt5a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa) |
| | rock2b | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa) |
| | ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) |
| | apc | APC regulator of WNT-signaling pathway. (2754 aa) |
| | ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) |
| | ved | Ventrally-expressed dharma/bozozok antagonist. (278 aa) |
| | rock1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1359 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | nap1l1 | Nucleosome assembly protein 1, like 1; Belongs to the nucleosome assembly protein (NAP) family. (385 aa) |
| | sp5l | Sp5 transcription factor-like. (357 aa) |
