STRINGSTRING
smad3a smad3a dap dap tbx16 tbx16 acvr1ba acvr1ba or102-2 or102-2 slc6a1b slc6a1b lft1 lft1 or103-4 or103-4 foxa2 foxa2 myod1 myod1 stat1a stat1a rpe65a rpe65a lhx1a lhx1a noto noto guk1b guk1b smad7 smad7 naca naca gata5 gata5 smad1 smad1 ube2d1b ube2d1b taf5l taf5l mapk1 mapk1 smad3b smad3b sult2st1 sult2st1 runx2b runx2b plp1b plp1b smad5 smad5 mitfa mitfa dharma dharma rtn1b rtn1b pdcb pdcb jun jun lft2 lft2 bambia bambia foxh1 foxh1 vamp2 vamp2 sri sri ptprna ptprna tgif1 tgif1 tcf7l1a tcf7l1a hbba1 hbba1 erh erh skib skib mapk3 mapk3 foxg1a foxg1a stat3 stat3 runx2a runx2a smad4a smad4a mpz mpz smad2 smad2 hoxc6a hoxc6a mixl1 mixl1 junba junba pcdh8 pcdh8 smad6a smad6a atp6v1h atp6v1h lef1 lef1 Q5TYR3_DANRE Q5TYR3_DANRE nfkb2 nfkb2 shha shha tcf7 tcf7 ep300b ep300b vent vent vox vox junbb junbb hmgb1a hmgb1a sox17 sox17 pax6a pax6a nfkb1 nfkb1 sox32 sox32 ved ved slc52a2-2 slc52a2-2 ndr2 ndr2 tbxta tbxta puf60b puf60b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
smad3aMothers against decapentaplegic homolog. (425 aa)
dapDeath-associated protein. (105 aa)
tbx16T-box transcription factor 16. (470 aa)
acvr1baReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
or102-2Olfactory receptor. (327 aa)
slc6a1bTransporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (600 aa)
lft1Left-right determination factor; Belongs to the TGF-beta family. (358 aa)
or103-4Odorant receptor, family C, subfamily 103, member 4. (318 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
stat1aSignal transducer and activator of transcription. (749 aa)
rpe65aRetinoid isomerohydrolase; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. Capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (By similarity). (531 aa)
lhx1aLIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa)
notoNotochord homeobox. (241 aa)
guk1bGuanylate kinase 1b. (223 aa)
smad7Mothers against decapentaplegic homolog. (372 aa)
nacaNascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes. (215 aa)
gata5Transcription factor gata5. (383 aa)
smad1Mothers against decapentaplegic homolog 1; Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. Belongs to the dwarfin/SMAD family. (472 aa)
ube2d1bUbiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (601 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
smad3bMothers against decapentaplegic homolog. (423 aa)
sult2st1Sulfotransferase; Belongs to the sulfotransferase 1 family. (287 aa)
runx2bRUNX family transcription factor 2b. (478 aa)
plp1bProteolipid protein 1b. (279 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
dharmaDharma. (192 aa)
rtn1bReticulon. (767 aa)
pdcbPhosducin b. (237 aa)
junJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa)
lft2Left-right determination factor. (362 aa)
bambiaBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (258 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
vamp2Vesicle-associated membrane protein 2. (110 aa)
sriSorcin. (190 aa)
ptprnaProtein tyrosine phosphatase receptor type Na. (903 aa)
tgif1TGFB-induced factor homeobox 1. (273 aa)
tcf7l1aTranscription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa)
hbba1Hemoglobin subunit beta-1; Involved in oxygen transport from gills to the various peripheral tissues; Belongs to the globin family. (148 aa)
erhEnhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family. (104 aa)
skibV-ski avian sarcoma viral oncogene homolog b. (695 aa)
mapk3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa)
foxg1aForkhead box G1a. (420 aa)
stat3Signal transducer and activator of transcription. (806 aa)
runx2aRunt-related transcription factor. (467 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
mpzMyelin protein zero. (203 aa)
smad2Mothers against decapentaplegic homolog 2; Promotes differentiation of dorsal tissues. May be involved in the mediation of Ndr2 signaling during mesoderm and axis formation during embryogenesis. (469 aa)
hoxc6aHomeobox protein Hox-C6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (208 aa)
mixl1Mix paired-like homeobox. (327 aa)
junbaJunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa)
pcdh8Protocadherin 8. (950 aa)
smad6aMothers against decapentaplegic homolog. (456 aa)
atp6v1hV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (481 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
Q5TYR3_DANRESi:dkey-174m14.3. (604 aa)
nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (902 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
tcf7Transcription factor 7. (355 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
ventVentral-expressed homeobox. (170 aa)
voxVentral homeobox. (242 aa)
junbbJunB proto-oncogene, AP-1 transcription factor subunit b. (310 aa)
hmgb1aHigh mobility group box 1a. (205 aa)
sox17SRY-box transcription factor 17. (413 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
nfkb1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
sox32SRY-box transcription factor 32. (307 aa)
vedVentrally-expressed dharma/bozozok antagonist. (278 aa)
slc52a2-2Zgc:109744. (885 aa)
ndr2Nodal-related 2. (505 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
puf60bPoly(U)-binding-splicing factor PUF60-B; DNA- and RNA-binding protein, involved in transcription repression and pre-mRNA splicing. (520 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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