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| | dusp6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa) |
| | fgf13b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (257 aa) |
| | fgfr1op2 | FGFR1 oncogene partner 2 homolog. (215 aa) |
| | map3k7 | Mitogen-activated protein kinase kinase kinase 7. (551 aa) |
| | fgf20a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | atf7a | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (497 aa) |
| | sh3gl3b | SH3-domain GRB2-like 3b. (386 aa) |
| | map2k1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (395 aa) |
| | fgf1a | Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa) |
| | usf1l | Upstream transcription factor 2, c-fos interacting. (283 aa) |
| | mycb | Transcriptional regulator Myc-B; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (396 aa) |
| | fgf6a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa) |
| | mycla | Protein L-Myc-1a. (372 aa) |
| | fgfr3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa) |
| | mapk4 | Mitogen-activated protein kinase 4. (674 aa) |
| | mapk8b | Mitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | map2k2a | Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (397 aa) |
| | map4k2 | Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (865 aa) |
| | igf2a | Insulin-like growth factor 2a. (197 aa) |
| | etv4 | ETS translocation variant 4; Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis. (494 aa) |
| | igf1ra | Tyrosine-protein kinase receptor. (1405 aa) |
| | igf1 | Insulin-like growth factor 1b. (161 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | mknk2b | MAPK-interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa) |
| | mapkapk2a | Mitogen-activated protein kinase-activated protein kinase 2a; Belongs to the protein kinase superfamily. (382 aa) |
| | zgc:55558 | Zgc:55558 protein. (187 aa) |
| | eif4e1b | Eukaryotic translation initiation factor 4E-1B; Does not appear to be a mRNA-cap-binding protein. (214 aa) |
| | fgf13a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa) |
| | tgfb3 | Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa) |
| | mycn | N-myc protein; May function as a transcription factor. (503 aa) |
| | her1 | Hairy-related 1. (328 aa) |
| | atf3 | Activating transcription factor 3. (202 aa) |
| | map4k5 | Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (878 aa) |
| | mapk14b | Mitogen-activated protein kinase 14B; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14b is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa) |
| | mapk1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa) |
| | tgfbr2b | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa) |
| | mapk14a | Mitogen-activated protein kinase 14A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Mapk14a is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are [...] (361 aa) |
| | th | Tyrosine hydroxylase. (489 aa) |
| | nr2f5 | Nuclear receptor subfamily 2 group F member 5; Putative receptor that is required in photoreceptor cells precursors during eye development; Belongs to the nuclear hormone receptor family. NR2 subfamily. (403 aa) |
| | fosab | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. (349 aa) |
| | sh3glb1b | SH3-domain GRB2-like endophilin B1b. (360 aa) |
| | igf1rb | Tyrosine-protein kinase receptor. (1380 aa) |
| | map3k5 | Mitogen-activated protein kinase kinase kinase 5. (1364 aa) |
| | braf | B-Raf proto-oncogene, serine/threonine kinase. (817 aa) |
| | fgf10a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa) |
| | kdr | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa) |
| | rap1aa | RAP1A, member of RAS oncogene family a. (185 aa) |
| | fgf5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa) |
| | sh3glb2a | SH3-domain GRB2-like endophilin B2a. (381 aa) |
| | rps6ka3a | Ribosomal protein S6 kinase. (732 aa) |
| | spry2 | Sprouty RTK-signaling antagonist 2. (301 aa) |
| | rras2 | Related RAS viral (R-ras) oncogene homolog 2. (202 aa) |
| | fgf24 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | nras | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (188 aa) |
| | fgf8b | Fibroblast growth factor 8b; May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system. (212 aa) |
| | fgf14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (248 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | igf2r | Cation-independent mannose 6-phosphate receptor. (2459 aa) |
| | fgf16 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa) |
| | cryaba | Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa) |
| | ptpn1 | Protein tyrosine phosphatase non-receptor type 1. (350 aa) |
| | cebpb | CCAAT/enhancer-binding protein. (280 aa) |
| | jun | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (308 aa) |
| | fgf18b | Fibroblast growth factor 18b; Belongs to the heparin-binding growth factors family. (213 aa) |
| | atf1 | Activating transcription factor 1. (304 aa) |
| | etv5b | ETS variant transcription factor 5b. (524 aa) |
| | dusp4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa) |
| | fgf23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (258 aa) |
| | egf | Epidermal growth factor. (1114 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | badb | BCL2-associated agonist of cell death b. (147 aa) |
| | raf1b | Raf-1 proto-oncogene, serine/threonine kinase b. (629 aa) |
| | fgfrl1a | Fibroblast growth factor receptor-like 1a. (483 aa) |
| | sos2 | Son of sevenless homolog 2 (Drosophila). (1341 aa) |
| | esr1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa) |
| | map3k8 | Mitogen-activated protein kinase kinase kinase 8. (472 aa) |
| | sh3gl2a | SH3 domain-containing GRB2-like 2a, endophilin A1. (347 aa) |
| | spry4 | Sprouty homolog 4 (Drosophila). (310 aa) |
| | pla2g4aa | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (741 aa) |
| | hgfa | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (699 aa) |
| | vegfc | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (396 aa) |
| | elk4 | ETS transcription factor ELK4. (443 aa) |
| | mapk3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (392 aa) |
| | pdgfaa | Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa) |
| | myca | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa) |
| | fgf22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | eif4ea | Eukaryotic translation initiation factor 4E-1A; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. (215 aa) |
| | map2k4a | Mitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa) |
| | fgf18a | Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa) |
| | fgf20b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | junba | JunB proto-oncogene, AP-1 transcription factor subunit a. (325 aa) |
| | max | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor (By similarity). (160 aa) |
| | mapkapk5 | Mitogen-activated protein kinase-activated protein kinase 5. (471 aa) |
| | sh3glb2b | SH3-domain GRB2-like endophilin B2b. (402 aa) |
| | fgf11a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa) |
| | araf | A-Raf proto-oncogene, serine/threonine kinase. (604 aa) |
| | mapk7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (1080 aa) |
| | hsf1 | Heat shock transcription factor 1. (523 aa) |
| | fgf7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (180 aa) |
| | grb2b | Growth factor receptor-bound protein 2b. (217 aa) |
| | elk3 | ETS transcription factor ELK3. (408 aa) |
| | tgfb2 | Transforming growth factor, beta 2. (413 aa) |
| | fgfr2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa) |
| | egfra | Epidermal growth factor receptor precursor. (625 aa) |
| | mbpa | Myelin basic protein a. (137 aa) |
| | rps6kal | Ribosomal protein S6 kinase alpha-6; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (740 aa) |
| | mapk6 | Extracellular signal-regulated kinase 3. (729 aa) |
| | raf1a | Raf-1 proto-oncogene, serine/threonine kinase a. (654 aa) |
| | junbb | JunB proto-oncogene, AP-1 transcription factor subunit b. (310 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | dusp2 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (333 aa) |
| | vegfaa | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa) |
| | mapk15 | Mitogen-activated protein kinase. (523 aa) |
| | fgf19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa) |
| | shcbp1 | SHC SH2-domain-binding protein 1. (721 aa) |
| | dusp1 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa) |
| | fgf17 | Fibroblast growth factor 17; Involved in dorsal-ventral embryonic patterning, by promoting expression of bone morphogenetic protein (BMP) antagonists such as chd. Also involved in anterior-posterior neural patterning and in mesoderm induction; Belongs to the heparin-binding growth factors family. (215 aa) |
| | fgfrl1b | Fibroblast growth factor receptor-like 1b. (481 aa) |
| | fgf10b | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa) |
| | il17rd | Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. (743 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | hrasa | HRas proto-oncogene, GTPase a. (189 aa) |
| | map2k6 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is n [...] (363 aa) |
| | atf4a | Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa) |
| | rps6ka1 | Ribosomal protein S6 kinase. (764 aa) |
