STRINGSTRING
bysl bysl dhx16 dhx16 rab5b rab5b esrrga esrrga rpl38 rpl38 gpc4 gpc4 adcyap1a adcyap1a gli2a gli2a wnt11f2 wnt11f2 smo smo nedd1 nedd1 rhoab rhoab rpl35 rpl35 aldoaa aldoaa nol10 nol10 rplp2l rplp2l insra insra def6a def6a stxbp1b stxbp1b pes pes adcyap1b adcyap1b rab5c rab5c nf2b nf2b ddx56 ddx56 tdgf1 tdgf1 cdk10 cdk10 igf2b igf2b rps19 rps19 wnt8b wnt8b rps3a rps3a oprm1 oprm1 rps29 rps29 fgf16 fgf16 yy1a yy1a cltca cltca rpl11 rpl11 otx1 otx1 tbc1d23 tbc1d23 kctd13 kctd13 st8sia3 st8sia3 cnbpa cnbpa apex1 apex1 rps8a rps8a ctcf ctcf ext2 ext2 ndr1 ndr1 lgi1b lgi1b ctnnb2 ctnnb2 rtn4a rtn4a tcf7l1a tcf7l1a mettl5 mettl5 dyrk1aa dyrk1aa esrrgb esrrgb rpl6 rpl6 llgl1 llgl1 cdipt cdipt insrb insrb zdhhc15b zdhhc15b boc boc csrnp1b csrnp1b bptf bptf fgf22 fgf22 zic1 zic1 LOC100535691 LOC100535691 auts2a auts2a scn12aa scn12aa rps4x rps4x rps15a rps15a gnl3 gnl3 smoc1 smoc1 znf385c znf385c vwc2 vwc2 wnt8a wnt8a snap29 snap29 fut8a fut8a usp25 usp25 pcdh19 pcdh19 mpi mpi disc1 disc1 tlcd3ba tlcd3ba med12 med12 nop58 nop58 hif1al hif1al mib1 mib1 ptpro-2 ptpro-2 ap1g2 ap1g2 axin1 axin1 rtn4b rtn4b usp43a usp43a glrx2 glrx2 scn5lab scn5lab ogt.1 ogt.1 ogt.2 ogt.2 apc apc top2a top2a ap1g1 ap1g1 ndr2 ndr2 chmp1a chmp1a pycr1b pycr1b vars1 vars1 rps3 rps3 appl1 appl1 elavl1b elavl1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
byslBystin-like. (466 aa)
dhx16DEAH (Asp-Glu-Ala-His) box polypeptide 16. (1054 aa)
rab5bRAB5B, member RAS oncogene family. (214 aa)
esrrgaEstrogen-related receptor gamma a. (501 aa)
rpl38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
gpc4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
adcyap1aAdenylate cyclase-activating polypeptide 1a. (199 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
wnt11f2Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
nedd1NEDD1 gamma-tubulin ring complex targeting factor. (677 aa)
rhoabRho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa)
rpl3560S ribosomal protein L35; Plays an essential role in early embryonic development. May act as a haploinsufficient tumor suppressor. Belongs to the universal ribosomal protein uL29 family. (123 aa)
aldoaaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
nol10Nucleolar protein 10. (722 aa)
rplp2lRibosomal protein, large P2,-like; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
insraTyrosine-protein kinase receptor. (1353 aa)
def6aDifferentially expressed in FDCP 6 homolog. (612 aa)
stxbp1bSyntaxin-binding protein 1b; Belongs to the STXBP/unc-18/SEC1 family. (605 aa)
pesPescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa)
adcyap1bAdenylate cyclase-activating polypeptide 1b. (175 aa)
rab5cRAB5C, member RAS oncogene family. (221 aa)
nf2bNeurofibromin 2b (merlin). (586 aa)
ddx56DEAD (Asp-Glu-Ala-Asp) box helicase 56. (557 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
cdk10Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa)
igf2bInsulin-like growth factor 2b. (212 aa)
rps19Ribosomal protein S19. (146 aa)
wnt8bProtein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa)
rps3a40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (267 aa)
oprm1Opioid receptor, mu 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
rps29Ribosomal protein S29. (56 aa)
fgf16Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa)
yy1aYY1 transcription factor a. (357 aa)
cltcaClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1680 aa)
rpl1160S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
otx1Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa)
tbc1d23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development. May act as a general inhibitor of innate immunity signaling (By similarity). (680 aa)
kctd13BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (By similarity). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission. (330 aa)
st8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (374 aa)
cnbpaCCHC-type zinc finger, nucleic acid-binding protein a. (163 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Required for passage through the midblastula trans [...] (310 aa)
rps8a40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
ctcfCCCTC-binding factor (zinc finger protein). (798 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
ndr1Nodal-related 1. (392 aa)
lgi1bLeucine-rich, glioma inactivated 1b. (543 aa)
ctnnb2Catenin, beta 2. (778 aa)
rtn4aReticulon. (322 aa)
tcf7l1aTranscription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa)
mettl5Methyltransferase-like 5. (207 aa)
dyrk1aaDual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, a. (737 aa)
esrrgbEstrogen-related receptor gamma b. (444 aa)
rpl6Ribosomal protein L6. (265 aa)
llgl1LLGL scribble cell polarity complex component 1. (304 aa)
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
insrbTyrosine-protein kinase receptor. (1348 aa)
zdhhc15bPalmitoyltransferase ZDHHC15B; Catalyzes palmitoylation of Cys residues on target proteins. (332 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
csrnp1bCysteine-serine-rich nuclear protein 1b. (566 aa)
bptfBromodomain PHD finger transcription factor. (2899 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
zic1ZIC family member 1 (Odd-paired homolog, Drosophila). (442 aa)
LOC100535691MYC-associated zinc finger protein a (purine-binding transcription factor). (506 aa)
auts2aActivator of transcription and developmental regulator AUTS2 a. (1278 aa)
scn12aaSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1932 aa)
rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
rps15a40S ribosomal protein S15a; Structural component of the ribosome (By similarity). Required for erythropoiesis during embryonic development. (130 aa)
gnl3Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa)
smoc1SPARC-related modular calcium-binding 1. (461 aa)
znf385cZinc finger protein 385C. (459 aa)
vwc2Von Willebrand factor C domain-containing 2. (309 aa)
wnt8aProtein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa)
snap29Synaptosome-associated protein 29. (232 aa)
fut8aAlpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (581 aa)
usp25Ubiquitin-specific peptidase 25; Belongs to the peptidase C19 family. (1072 aa)
pcdh19Protocadherin 19. (1088 aa)
mpiMannose-6-phosphate isomerase. (422 aa)
disc1DISC1 scaffold protein. (994 aa)
tlcd3baTLC domain-containing 3Ba. (292 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
nop58NOP58 ribonucleoprotein homolog (yeast). (553 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
ptpro-2Protein tyrosine phosphatase receptor type O. (866 aa)
ap1g2AP-1 complex subunit gamma. (794 aa)
axin1Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa)
rtn4bReticulon. (876 aa)
usp43aUbiquitin-specific peptidase 43a; Belongs to the peptidase C19 family. (1122 aa)
glrx2Glutaredoxin 2. (170 aa)
scn5labSodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1954 aa)
ogt.1O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1062 aa)
ogt.2O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1102 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa)
ap1g1AP-1 complex subunit gamma. (819 aa)
ndr2Nodal-related 2. (505 aa)
chmp1aCharged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). Belongs to the SNF7 family. (198 aa)
pycr1bPyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (329 aa)
vars1Valyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1271 aa)
rps3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
appl1HESX homeobox 1. (718 aa)
elavl1bELAV-like protein; Belongs to the RRM elav family. (360 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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