STRINGSTRING
cdh2 cdh2 mipb mipb rpl38 rpl38 cdh11 cdh11 wdr36 wdr36 dnmt1 dnmt1 smo smo fgf8a fgf8a chm chm mab21l2 mab21l2 dag1 dag1 rplp2l rplp2l sox21b sox21b unc45b unc45b lamc1 lamc1 lgsn lgsn ptch1 ptch1 itga5 itga5 tdgf1 tdgf1 rps3a rps3a pitx2 pitx2 mipa mipa gdf3 gdf3 nsfb nsfb bbs5 bbs5 rps29 rps29 cryaba cryaba rplp0 rplp0 gdf6a gdf6a aldh1a2 aldh1a2 cryaa cryaa pax2a pax2a rpl36a rpl36a plk1 plk1 bves bves hhip hhip vps45 vps45 foxe3 foxe3 yap1 yap1 rpl6 rpl6 alox12 alox12 pitx3 pitx3 psmd6 psmd6 cdipt cdipt chsy1 chsy1 mif mif ocrl ocrl cerkl cerkl dmbx1a dmbx1a prpf3 prpf3 rps4x rps4x dnmt3bb.2 dnmt3bb.2 fn1a fn1a hsf1 hsf1 dnajb1b dnajb1b mpp5a mpp5a alx1 alx1 lrrk2 lrrk2 cryabb cryabb lrp2a lrp2a lamb1a lamb1a sufu sufu cdh4 cdh4 uhrf1 uhrf1 lama1 lama1 fgf19 fgf19 top2a top2a inpp5ka inpp5ka dnajb1a dnajb1a vars1 vars1 cnot8 cnot8 sipa1l3 sipa1l3 pax6b pax6b rps3 rps3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
mipbMajor intrinsic protein of lens fiber b; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
rpl38Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family. (70 aa)
cdh11Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
wdr36WD repeat domain 36. (896 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
chmRab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
mab21l2Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family. (359 aa)
dag1Dystroglycan 1. (866 aa)
rplp2lRibosomal protein, large P2,-like; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
sox21bTranscription factor Sox-21-B; Acts as a negative regulator of transcription. (245 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
lgsnLengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (668 aa)
ptch1Protein patched homolog 1. (1475 aa)
itga5Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1053 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
rps3a40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (267 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
mipaMajor intrinsic protein of lens fiber 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
gdf3Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa)
nsfbN-ethylmaleimide-sensitive factor b. (747 aa)
bbs5Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa)
rps29Ribosomal protein S29. (56 aa)
cryabaCrystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa)
rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (316 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
cryaaCrystallin, alpha A; Belongs to the small heat shock protein (HSP20) family. (173 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
rpl36a60S ribosomal protein L36a. (106 aa)
plk1Serine/threonine-protein kinase PLK. (595 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
hhipHedgehog-interacting protein. (693 aa)
vps45Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (568 aa)
foxe3Forkhead box E3. (422 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
rpl6Ribosomal protein L6. (265 aa)
alox12Arachidonate 12-lipoxygenase. (670 aa)
pitx3Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (386 aa)
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa)
chsy1Hexosyltransferase. (801 aa)
mifMacrophage migration inhibitory factor. (115 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
cerklCeramide kinase-like. (577 aa)
dmbx1aDiencephalon/mesencephalon homeobox protein 1-A; Required for eye and tectum development. May act as a transcriptional repressor. (383 aa)
prpf3PRP3 pre-mRNA-processing factor 3 homolog (yeast). (699 aa)
rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
dnmt3bb.2DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1448 aa)
fn1aFibronectin 1a. (2480 aa)
hsf1Heat shock transcription factor 1. (523 aa)
dnajb1bDnaJ heat shock protein family (Hsp40) member B1b. (340 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
alx1ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development ; Belongs to the paired homeobox family. (320 aa)
lrrk2Leucine-rich repeat kinase 2. (2532 aa)
cryabbCrystallin, alpha B, b; Belongs to the small heat shock protein (HSP20) family. (165 aa)
lrp2aLow density lipoprotein receptor-related protein 2a. (4673 aa)
lamb1aLaminin, beta 1a. (1785 aa)
sufuSuppressor of fused homolog. (485 aa)
cdh4Cadherin 4, type 1, R-cadherin (retinal); Cadherins are calcium-dependent cell adhesion proteins. (931 aa)
uhrf1E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa)
lama1Laminin, alpha 1. (3075 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa)
inpp5kaInositol polyphosphate-5-phosphatase Ka. (476 aa)
dnajb1aDnaJ heat shock protein family (Hsp40) member B1a. (335 aa)
vars1Valyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1271 aa)
cnot8CCR4-NOT transcription complex, subunit 8. (285 aa)
sipa1l3Signal-induced proliferation-associated 1-like 3. (1718 aa)
pax6bPaired box 6b. (450 aa)
rps3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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