node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dzip1 | gli1 | ENSDARP00000105423 | ENSDARP00000129932 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | GLI family zinc finger 1. | 0.580 |
dzip1 | gli2a | ENSDARP00000105423 | ENSDARP00000010693 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | GLI family zinc finger 2a. | 0.824 |
dzip1 | smo | ENSDARP00000105423 | ENSDARP00000013486 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.564 |
foxh1 | noto | ENSDARP00000072485 | ENSDARP00000022555 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. | Notochord homeobox. | 0.572 |
gli1 | dzip1 | ENSDARP00000129932 | ENSDARP00000105423 | GLI family zinc finger 1. | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | 0.580 |
gli1 | gli2a | ENSDARP00000129932 | ENSDARP00000010693 | GLI family zinc finger 1. | GLI family zinc finger 2a. | 0.604 |
gli1 | nkx2.2a | ENSDARP00000129932 | ENSDARP00000153588 | GLI family zinc finger 1. | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | 0.578 |
gli1 | smo | ENSDARP00000129932 | ENSDARP00000013486 | GLI family zinc finger 1. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.963 |
gli1 | stk36 | ENSDARP00000129932 | ENSDARP00000081199 | GLI family zinc finger 1. | Serine/threonine kinase 36 (fused homolog, Drosophila). | 0.614 |
gli2a | dzip1 | ENSDARP00000010693 | ENSDARP00000105423 | GLI family zinc finger 2a. | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. | 0.824 |
gli2a | gli1 | ENSDARP00000010693 | ENSDARP00000129932 | GLI family zinc finger 2a. | GLI family zinc finger 1. | 0.604 |
gli2a | nkx2.2a | ENSDARP00000010693 | ENSDARP00000153588 | GLI family zinc finger 2a. | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | 0.672 |
gli2a | smo | ENSDARP00000010693 | ENSDARP00000013486 | GLI family zinc finger 2a. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.990 |
gli2a | stk36 | ENSDARP00000010693 | ENSDARP00000081199 | GLI family zinc finger 2a. | Serine/threonine kinase 36 (fused homolog, Drosophila). | 0.679 |
gli2b | smo | ENSDARP00000015266 | ENSDARP00000013486 | GLI family zinc finger 2b. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.668 |
gli2b | stk36 | ENSDARP00000015266 | ENSDARP00000081199 | GLI family zinc finger 2b. | Serine/threonine kinase 36 (fused homolog, Drosophila). | 0.601 |
nkx2.2a | gli1 | ENSDARP00000153588 | ENSDARP00000129932 | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | GLI family zinc finger 1. | 0.578 |
nkx2.2a | gli2a | ENSDARP00000153588 | ENSDARP00000010693 | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | GLI family zinc finger 2a. | 0.672 |
nkx2.2a | smo | ENSDARP00000153588 | ENSDARP00000013486 | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.680 |
noto | foxh1 | ENSDARP00000022555 | ENSDARP00000072485 | Notochord homeobox. | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. | 0.572 |