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traf3ip1 traf3ip1 rasl11b rasl11b rpl5a rpl5a zmynd10 zmynd10 foxa2 foxa2 rer1 rer1 gli2a gli2a ruvbl1 ruvbl1 isl1 isl1 dnmt1 dnmt1 smo smo ift57 ift57 invs invs pink1 pink1 ift81 ift81 wls wls snx5 snx5 fgf8a fgf8a msx3 msx3 dhrs9 dhrs9 vangl2 vangl2 desi2 desi2 ift88 ift88 suv39h1a suv39h1a tsc1a tsc1a llgl2 llgl2 camk2a camk2a flvcr1 flvcr1 tdgf1 tdgf1 dicer1 dicer1 rps19 rps19 slc3a2a slc3a2a gdf3 gdf3 prickle1a prickle1a ift172 ift172 supt5h supt5h disp1 disp1 abcc4 abcc4 pou5f3 pou5f3 cnbpa cnbpa ccdc103 ccdc103 aldh1a2 aldh1a2 dcdc2b dcdc2b fzd2 fzd2 ruvbl2 ruvbl2 foxh1 foxh1 ezrb ezrb fktn fktn gon4l gon4l amotl2a amotl2a scospondin scospondin wnt3a wnt3a col2a1a col2a1a ptger4a ptger4a arl13b arl13b mif mif boc boc rabep1 rabep1 ptgs1 ptgs1 cfap298 cfap298 dzip1 dzip1 arrb1 arrb1 ptena ptena rps7 rps7 elp3 elp3 urp1 urp1 lmo7b lmo7b dnaaf1 dnaaf1 wnt8a wnt8a med23 med23 daw1 daw1 mef2aa mef2aa uts2r3 uts2r3 tfr1b tfr1b ahi1 ahi1 apobec2a apobec2a cdc14b cdc14b cep290 cep290 rab8a rab8a synpo2lb synpo2lb dnmbp dnmbp cdc73 cdc73 gli1 gli1 dnaaf4 dnaaf4 nop58 nop58 sbno2a sbno2a kif3b kif3b fkrp fkrp wnt5a wnt5a col22a1 col22a1 ccdc40 ccdc40 tekt1 tekt1 ctnnb1 ctnnb1 col2a1b col2a1b top2a top2a znf45l znf45l hspg2 hspg2 ndr2 ndr2 mpp7a mpp7a cav1 cav1 ift20 ift20 wdr19 wdr19 dub dub
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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traf3ip1TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (629 aa)
rasl11bRas-like protein family member 11B; Belongs to the small GTPase superfamily. Ras family. (244 aa)
rpl5aRibosomal protein L5a. (297 aa)
zmynd10Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility (By similarity). May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family. (448 aa)
foxa2Forkhead box protein A2; May play a crucial role in specification of both the axial mesendoderm and the ventral nervous system. (409 aa)
rer1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
ruvbl1RuvB-like 1; Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP- dependent nucleosome sliding (By similarity). May act as a negative regulator of embryonic heart growth. Belongs to the RuvB family. (456 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
ift57Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. (407 aa)
invsInversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. (1025 aa)
pink1PTEN-induced kinase 1. (574 aa)
ift81Intraflagellar transport 81 homolog. (675 aa)
wlsWnt ligand secretion mediator. (542 aa)
snx5Sorting nexin; Involved in several stages of intracellular trafficking. Belongs to the sorting nexin family. (399 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
msx3Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. (273 aa)
dhrs9Dehydrogenase/reductase (SDR family) member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
desi2Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. (196 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
suv39h1aHistone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
llgl2LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa)
camk2aCalcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
flvcr1FLVCR heme transporter 1. (527 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
dicer1Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1865 aa)
rps19Ribosomal protein S19. (146 aa)
slc3a2aSolute carrier family 3 member 2a. (485 aa)
gdf3Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa)
prickle1aPrickle homolog 1a. (793 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
supt5hTranscription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] (1084 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
abcc4ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1327 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
cnbpaCCHC-type zinc finger, nucleic acid-binding protein a. (163 aa)
ccdc103Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. Belongs to the CCDC103/PR46b family. (247 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
dcdc2bDoublecortin domain-containing 2B. (447 aa)
fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa)
ruvbl2RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] (463 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
ezrbEzrin b. (583 aa)
fktnFukutin. (457 aa)
gon4lGon-4-like (C. elegans). (2055 aa)
amotl2aAngiomotin-like 2a; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. (721 aa)
scospondinSubcommissural organ spondin. (4633 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
col2a1aCollagen, type II, alpha 1a. (1491 aa)
ptger4aProstaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (403 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
mifMacrophage migration inhibitory factor. (115 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
rabep1Rabaptin, RAB GTPase-binding effector protein 1. (850 aa)
ptgs1Prostaglandin-endoperoxide synthase 1. (597 aa)
cfap298Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. (290 aa)
dzip1Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa)
arrb1Arrestin, beta 1. (418 aa)
ptenaPhosphatase and tensin homolog A; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (467 aa)
rps740S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (194 aa)
elp3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at po [...] (533 aa)
urp1Urotensin-related peptide 1. (127 aa)
lmo7bLIM domain 7b. (1384 aa)
dnaaf1Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (Probable). (562 aa)
wnt8aProtein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa)
med23Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1387 aa)
daw1Dynein assembly factor with WDR repeat domains 1; Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. (418 aa)
mef2aaMyocyte enhancer factor 2aa. (458 aa)
uts2r3Urotensin-2 receptor 3; Belongs to the G-protein coupled receptor 1 family. (386 aa)
tfr1bTransferrin receptor 1b. (771 aa)
ahi1Abelson helper integration site 1. (1193 aa)
apobec2aApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2a. (266 aa)
cdc14bCell division cycle 14B. (476 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
rab8aRAB8A, member RAS oncogene family. (207 aa)
synpo2lbSynaptopodin 2-like b. (1184 aa)
dnmbpDynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton (By similarity). Plays a central role in renal ciliogenesis and kidney development. (1673 aa)
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa)
gli1GLI family zinc finger 1. (1404 aa)
dnaaf4Dynein axonemal assembly factor 4. (420 aa)
nop58NOP58 ribonucleoprotein homolog (yeast). (553 aa)
sbno2aStrawberry notch homolog 2a. (1350 aa)
kif3bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (775 aa)
fkrpFukutin-related protein. (536 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
col22a1Collagen, type XXII, alpha 1. (1622 aa)
ccdc40Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. (941 aa)
tekt1Tektin 1. (402 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
col2a1bCollagen, type II, alpha 1b. (1344 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa)
znf45lZinc finger 45-like. (407 aa)
hspg2Heparan sulfate proteoglycan 2. (3462 aa)
ndr2Nodal-related 2. (505 aa)
mpp7aMAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). Belongs to the MAGUK family. (576 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
ift20Intraflagellar transport protein 20 homolog; Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. (132 aa)
wdr19WD repeat domain 19. (1372 aa)
dubDuboraya. (305 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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