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| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | hmx4 | H6 family homeobox 4. (238 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | ift57 | Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. (407 aa) |
| | rras | Related RAS viral (R-ras) oncogene homolog. (196 aa) |
| | chrnd | Cholinergic receptor, nicotinic, delta (muscle). (518 aa) |
| | bmp7a | Bone morphogenetic protein 7a. (432 aa) |
| | rsph9 | Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules. (277 aa) |
| | zic2a | ZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa) |
| | rgma | Repulsive guidance molecule BMP co-receptor a. (449 aa) |
| | glra4a | Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | ift88 | Intraflagellar transport 88 homolog. (824 aa) |
| | tdgf1 | Teratocarcinoma-derived growth factor 1. (190 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | cdk10 | Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa) |
| | tle3a | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa) |
| | porcn | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (442 aa) |
| | marcksl1b | MARCKS-related protein 1-B; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. (207 aa) |
| | pard6gb | Par-6 partitioning defective 6-like protein gamma. (434 aa) |
| | ache | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa) |
| | has2 | Hyaluronan synthase 2. (552 aa) |
| | marcksl1a | MARCKS-related protein 1-A; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. (213 aa) |
| | ift172 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa) |
| | disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) |
| | scrib | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa) |
| | htt | Huntingtin. (3121 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | lzic | Protein LZIC; Required for neuronal survival during early development. (190 aa) |
| | ndr1 | Nodal-related 1. (392 aa) |
| | scinlb | Scinderin-like b. (720 aa) |
| | plk1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | ctnnb2 | Catenin, beta 2. (778 aa) |
| | crb2a | Crumbs cell polarity complex component 2a. (1466 aa) |
| | map1b | Hypothetical microtubule-associated protein 1b. (2033 aa) |
| | nipblb | Nipped-B-like protein B; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). (2882 aa) |
| | ccdc85b | Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (By similarity). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). (200 aa) |
| | gas2l3 | Growth arrest-specific 2-like 3. (550 aa) |
| | fbxl18 | F-box and leucine-rich repeat protein 18. (720 aa) |
| | ids | Iduronate 2-sulfatase. (561 aa) |
| | kank3 | KN motif and ankyrin repeat domains 3. (914 aa) |
| | appl2 | Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper-containing 2. (662 aa) |
| | birc5a | Baculoviral IAP repeat-containing 5a. (190 aa) |
| | cfap298 | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity ; Belongs to the CFAP298 family. (290 aa) |
| | dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) |
| | rnf152 | E3 ubiquitin-protein ligase rnf152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation; Belongs to the RNF152 family. (197 aa) |
| | bmp2b | Bone morphogenetic protein 2b. (411 aa) |
| | fto | FTO alpha-ketoglutarate-dependent dioxygenase. (567 aa) |
| | pard3ab | Par-3 family cell polarity regulator alpha, b. (1332 aa) |
| | cep120 | Centrosomal protein 120. (929 aa) |
| | enpp1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa) |
| | h3f3a | H3 histone, family 3B.1. (136 aa) |
| | birc5b | Baculoviral IAP repeat-containing 5b. (144 aa) |
| | golgb1 | Golgin B1. (3355 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | tgfb2 | Transforming growth factor, beta 2. (413 aa) |
| | wdr43 | WD repeat domain 43. (650 aa) |
| | cyfip2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa) |
| | tert | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | gli1 | GLI family zinc finger 1. (1404 aa) |
| | polr1a | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1693 aa) |
| | fgfbp1a | Fibroblast growth factor-binding protein 1b. (197 aa) |
| | lamb1a | Laminin, beta 1a. (1785 aa) |
| | talpid3 | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | fkrp | Fukutin-related protein. (536 aa) |
| | rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa) |
| | cdh1 | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. (877 aa) |
| | neo1a | Neogenin 1a. (1428 aa) |
| | cenpw | Centromere protein W. (98 aa) |
| | top2a | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa) |
| | jmjd6 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as u2af2/u2af65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of u2af2/u2af65, affecting the pre-mRNA splicing activity of u2af2/u2af65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] (403 aa) |
| | pcdh10a | Protocadherin 10a. (1001 aa) |
| | bbs9 | Bardet-Biedl syndrome 9. (842 aa) |
| | grk3 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (701 aa) |
