STRINGSTRING
tbx16 tbx16 smo smo rpl35 rpl35 rplp2l rplp2l smc3 smc3 parp3 parp3 foxl1 foxl1 tbx5a tbx5a rarab rarab fgf10a fgf10a rps19 rps19 rps3a rps3a hdac1 hdac1 smad5 smad5 tll1 tll1 rps29 rps29 ccn2a ccn2a rplp0 rplp0 aldh1a2 aldh1a2 rps8a rps8a ext2 ext2 hhip hhip yap1 yap1 rpl6 rpl6 eda eda wnt2ba wnt2ba pbx4 pbx4 pi4kaa pi4kaa rps4x rps4x rps15a rps15a fibinb fibinb lef1 lef1 masp1 masp1 edar edar sufu sufu rps3 rps3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tbx16T-box transcription factor 16. (470 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
rpl3560S ribosomal protein L35; Plays an essential role in early embryonic development. May act as a haploinsufficient tumor suppressor. Belongs to the universal ribosomal protein uL29 family. (123 aa)
rplp2lRibosomal protein, large P2,-like; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
smc3Structural maintenance of chromosomes protein. (1216 aa)
parp3Poly [ADP-ribose] polymerase. (531 aa)
foxl1Forkhead transcription factor. (360 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
rarabRetinoic acid receptor alpha-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins; Belongs to the nuclear hormone receptor family. NR1 subfamily. (458 aa)
fgf10aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
rps19Ribosomal protein S19. (146 aa)
rps3a40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (267 aa)
hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
tll1Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa)
rps29Ribosomal protein S29. (56 aa)
ccn2aNovel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa)
rplp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10; Belongs to the universal ribosomal protein uL10 family. (316 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
rps8a40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
hhipHedgehog-interacting protein. (693 aa)
yap1Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa)
rpl6Ribosomal protein L6. (265 aa)
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
pbx4Pre-B-cell leukemia transcription factor 4. (343 aa)
pi4kaaPhosphatidylinositol 4-kinase, catalytic, alpha a; Belongs to the PI3/PI4-kinase family. (2059 aa)
rps4x40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
rps15a40S ribosomal protein S15a; Structural component of the ribosome (By similarity). Required for erythropoiesis during embryonic development. (130 aa)
fibinbFin bud initiation factor; Essential for the initiation of pectoral fin bud formation. Potentially acts downstream of retinoic acid and Wnt signaling and is required for tbx5 expression in the lateral plate mesoderm of presumptive pectoral fin bud regions; Belongs to the FIBIN family. (210 aa)
lef1Lymphocyte enhancer binding factor 1 Lef1. (365 aa)
masp1Mannan-binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (740 aa)
edarEctodysplasin A receptor. (460 aa)
sufuSuppressor of fused homolog. (485 aa)
rps3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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