STRINGSTRING
traf3ip1 traf3ip1 cdh2 cdh2 cdc14aa cdc14aa gli2a gli2a unc119.1 unc119.1 uqcrb uqcrb smo smo invs invs ift81 ift81 ctr9 ctr9 igf2a igf2a nup88 nup88 rab5c rab5c ift88 ift88 pafah1b1b pafah1b1b pafah1b1a pafah1b1a igf2b igf2b hexb hexb flr flr prickle1a prickle1a rack1 rack1 ift172 ift172 disp2 disp2 nphp1 nphp1 prrc1 prrc1 ift52 ift52 rassf8b rassf8b stra6 stra6 ruvbl2 ruvbl2 jazf1b jazf1b gfpt1 gfpt1 wdr34 wdr34 ubap1 ubap1 cavin1b cavin1b cep131 cep131 lpar6a lpar6a wwtr1 wwtr1 col2a1a col2a1a arl13b arl13b agbl5 agbl5 C10H5orf30 C10H5orf30 mak16 mak16 cluap1 cluap1 ror2 ror2 nphp3 nphp3 cep70 cep70 kif3a kif3a mta3 mta3 ran ran nphp4 nphp4 rtf1 rtf1 kdm5c kdm5c iqce iqce ift80 ift80 myo1hb myo1hb myo1ha myo1ha adamts9 adamts9 mpp5a mpp5a met met apobec2a apobec2a cep290 cep290 gli1 gli1 med12 med12 hspb7 hspb7 psmd2 psmd2 ift27 ift27 agtpbp1 agtpbp1 iqcb1 iqcb1 kif3b kif3b foxj1a foxj1a aqp11 aqp11 srrm4 srrm4 mcc mcc fgf10b fgf10b cfap20 cfap20 nrp1a nrp1a zmiz2 zmiz2 cav1 cav1 cxxc5a cxxc5a usp10 usp10 pald1a pald1a apobec2b apobec2b cdx1b cdx1b DYNC2H1 DYNC2H1 phf21ab phf21ab
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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traf3ip1TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1 and recruits TRAF3 and DISC1 to the microtubules. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity). (629 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
cdc14aaCell division cycle 14Aa. (592 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
unc119.1Protein unc-119 homolog B; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in localization of proteins to the primary cilium membrane. Belongs to the PDE6D/unc-119 family. (243 aa)
uqcrbCytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (111 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
invsInversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. (1025 aa)
ift81Intraflagellar transport 81 homolog. (675 aa)
ctr9CTR9 homolog, Paf1/RNA polymerase II complex component. (1160 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
nup88Nucleoporin 88; Component of the nuclear pore complex. (720 aa)
rab5cRAB5C, member RAS oncogene family. (221 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
pafah1b1bLissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa)
pafah1b1aLissencephaly-1 homolog A; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
igf2bInsulin-like growth factor 2b. (212 aa)
hexbBeta-hexosaminidase. (541 aa)
flrTetratricopeptide repeat protein 30A; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity). Required for polyglutamylation of axonemal tubulin, which is a prerequisite for correct assembly of cilia and for normal cilia beat amplitude. Does not seem to be required for neuronal microtubule polyglutamylation. (651 aa)
prickle1aPrickle homolog 1a. (793 aa)
rack1Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (317 aa)
ift172Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa)
disp2Protein dispatched homolog 2; Belongs to the dispatched family. (1476 aa)
nphp1Nephronophthisis 1. (667 aa)
prrc1Protein PRRC1. (435 aa)
ift52Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa)
rassf8bRas association domain family member 8b. (420 aa)
stra6Receptor for retinol uptake stra6; Retinol transporter. Accepts retinol from the extracellular retinol-binding protein rbp4, mediates retinol transport across the cell membrane, and then transmits retinol to the cytoplasmic retinol- binding protein rbp1. Required for normal vitamin A homeostasis. (670 aa)
ruvbl2RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] (463 aa)
jazf1bZinc finger protein Seson. (243 aa)
gfpt1Glutamine--fructose-6-phosphate transaminase 1. (682 aa)
wdr34WD repeat domain 34. (501 aa)
ubap1Ubiquitin-associated protein 1; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). (453 aa)
cavin1bPolymerase I and transcript release factor. (454 aa)
cep131Centrosomal protein of 131 kDa; Cilium-specific protein required for the regulation of cilium/flagellum formation. Involved in centriole duplication (By similarity). May play a role in melanosome trafficking ; Belongs to the CEP131 family. (1111 aa)
lpar6aLysophosphatidic acid receptor 6a; Belongs to the G-protein coupled receptor 1 family. (357 aa)
wwtr1WW domain-containing transcription regulator 1. (391 aa)
col2a1aCollagen, type II, alpha 1a. (1491 aa)
arl13bADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] (407 aa)
agbl5Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains. (885 aa)
C10H5orf30Macrophage immunometabolism regulator; May play a role in immune regulation through regulation of the macrophage function (By similarity). Involved in the recruitment of macrophages in response to injury. May also play a role in trafficking of proteins via its interaction with unc119 family cargo adapters (By similarity). May play a role in ciliary membrane localization. (206 aa)
mak16Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa)
cluap1Clusterin-associated protein 1 homolog; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Belongs to the CLUAP1 family. (427 aa)
ror2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (939 aa)
nphp3Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. (1303 aa)
cep70Centrosomal protein 70. (609 aa)
kif3aKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa)
mta3Metastasis-associated 1 family, member 3. (517 aa)
ranGTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (215 aa)
nphp4Si:dkey-202c5.1 protein. (189 aa)
rtf1RTF1 homolog, Paf1/RNA polymerase II complex component. (701 aa)
kdm5cLysine (K)-specific demethylase 5C. (1578 aa)
iqceIQ motif-containing E. (680 aa)
ift80Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
myo1hbMyosin IHb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (993 aa)
myo1haMyosin IHa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1027 aa)
adamts9ADAM metallopeptidase with thrombospondin type 1 motif, 9. (1461 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
metMET proto-oncogene, receptor tyrosine kinase. (1382 aa)
apobec2aApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2a. (266 aa)
cep290Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa)
gli1GLI family zinc finger 1. (1404 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
hspb7Heat shock protein family, member 7 (cardiovascular); Belongs to the small heat shock protein (HSP20) family. (161 aa)
psmd2Proteasome 26S subunit, non-ATPase 2. (348 aa)
ift27Intraflagellar transport 27 homolog (Chlamydomonas). (186 aa)
agtpbp1Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1153 aa)
iqcb1IQ motif-containing B1. (595 aa)
kif3bKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (775 aa)
foxj1aForkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia. (458 aa)
aqp11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (275 aa)
srrm4Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural- specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2 (By similarity). (574 aa)
mccMCC regulator of WNT-signaling pathway. (975 aa)
fgf10bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
cfap20Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). Plays a role in cilia stability. (192 aa)
nrp1aNeuropilin-1a; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. Regulates angiogenesis through a VEGF-dependent pathway. (923 aa)
zmiz2Zinc finger, MIZ-type-containing 2. (902 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
cxxc5aCXXC finger protein 5a. (284 aa)
usp10Ubiquitin carboxyl-terminal hydrolase. (898 aa)
pald1aPaladin. (862 aa)
apobec2bApolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 2b. (273 aa)
cdx1bCaudal type homeodomain protein. (255 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4208 aa)
phf21abPHD finger protein 21Ab. (828 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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