STRINGSTRING
mmp2 mmp2 cdh11 cdh11 gli2a gli2a robo2 robo2 fgf8a fgf8a mmp14a mmp14a slc35b2 slc35b2 rb1 rb1 mycbp2 mycbp2 pigk pigk disp1 disp1 col4a5 col4a5 gdf6a gdf6a pax2a pax2a ptch2 ptch2 ext2 ext2 adcy8 adcy8 slc17a6b slc17a6b alcamb alcamb atoh7 atoh7 boc boc dzip1 dzip1 col4a6 col4a6 top2b top2b lhx2b lhx2b ahi1 ahi1 extl3 extl3 cyfip2 cyfip2 shha shha gli1 gli1 cpsf1 cpsf1 cdh4 cdh4 lama1 lama1 fgf19 fgf19 apc apc slbp slbp ndr2 ndr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mmp2Matrix metalloproteinase 2. (657 aa)
cdh11Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
gli2aGLI family zinc finger 2a. (1439 aa)
robo2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1387 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
mmp14aMatrix metallopeptidase 14a (membrane-inserted). (574 aa)
slc35b2Solute carrier family 35, member B2. (435 aa)
rb1Retinoblastoma 1. (903 aa)
mycbp2E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...] (4574 aa)
pigkGPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (389 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
col4a5Collagen, type IV, alpha 5 (Alport syndrome). (1679 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (892 aa)
slc17a6bVesicular glutamate transporter 2.1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. Required for glutamate release by retinotectal synapses and visual acuity. (584 aa)
alcambActivated leukocyte cell adhesion molecule b. (562 aa)
atoh7Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
dzip1Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa)
col4a6Collagen, type IV, alpha 6. (1714 aa)
top2bDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1618 aa)
lhx2bLIM homeobox 2b. (427 aa)
ahi1Abelson helper integration site 1. (1193 aa)
extl3Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (917 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
gli1GLI family zinc finger 1. (1404 aa)
cpsf1Cleavage and polyadenylation-specific factor 1. (1451 aa)
cdh4Cadherin 4, type 1, R-cadherin (retinal); Cadherins are calcium-dependent cell adhesion proteins. (931 aa)
lama1Laminin, alpha 1. (3075 aa)
fgf19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
slbpStem-loop-binding protein. (302 aa)
ndr2Nodal-related 2. (505 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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