STRINGSTRING
cdh11 cdh11 jag1b jag1b smo smo pink1 pink1 fgf8a fgf8a ptch1 ptch1 psmd3 psmd3 tbx2a tbx2a sparc sparc tbx1 tbx1 stxbp3 stxbp3 atp6v1e1b atp6v1e1b taf1 taf1 cars1 cars1 pou5f3 pou5f3 lmx1bb lmx1bb cog4 cog4 chaf1b chaf1b tfip11 tfip11 slc25a1a slc25a1a atp1a1a.1 atp1a1a.1 shrprbck1r shrprbck1r hhip hhip catip catip sox10 sox10 atp6ap2 atp6ap2 tp73 tp73 rtf1 rtf1 tmie tmie dio2 dio2 mdn1 mdn1 msrb3 msrb3 sharpin sharpin cdc73 cdc73 med12 med12 polr1a polr1a sufu sufu foxi1 foxi1 slc12a2 slc12a2 slc44a4 slc44a4 nop14 nop14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdh11Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
pink1PTEN-induced kinase 1. (574 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
ptch1Protein patched homolog 1. (1475 aa)
psmd3Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3. (503 aa)
tbx2aT-box transcription factor 2a. (686 aa)
sparcSecreted protein, acidic, cysteine-rich (osteonectin). (291 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
stxbp3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
atp6v1e1bATPase H+-transporting V1 subunit E1b. (226 aa)
taf1Transcription initiation factor TFIID subunit. (1947 aa)
cars1Cysteinyl-tRNA synthetase. (824 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
lmx1bbLIM homeobox transcription factor 1, beta 1. (375 aa)
cog4Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity); Belongs to the COG4 family. (781 aa)
chaf1bChromatin assembly factor 1, subunit B. (613 aa)
tfip11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. (832 aa)
slc25a1aTricarboxylate transport protein A, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate (By similarity). Required for proper neuromuscular junction formation. (359 aa)
atp1a1a.1Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
shrprbck1rRanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('M- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. (714 aa)
hhipHedgehog-interacting protein. (693 aa)
catipCiliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization. (356 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
atp6ap2ATPase H+-transporting accessory protein 2. (386 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa)
rtf1RTF1 homolog, Paf1/RNA polymerase II complex component. (701 aa)
tmieTransmembrane inner ear. (231 aa)
dio2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (258 aa)
mdn1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5523 aa)
msrb3Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (200 aa)
sharpinSHANK-associated RH domain-interacting protein. (394 aa)
cdc73Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa)
med12Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa)
polr1aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1693 aa)
sufuSuppressor of fused homolog. (485 aa)
foxi1Forkhead box I1. (377 aa)
slc12a2Solute carrier family 12 member 2. (1136 aa)
slc44a4Choline transporter-like protein 4; Choline transporter that seems to play a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury; Belongs to the CTL (choline transporter-like) family. (703 aa)
nop14NOP14 nucleolar protein homolog (yeast). (767 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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