STRINGSTRING
acvr1l acvr1l med15 med15 prdm1a prdm1a acsl4a acsl4a mapk8b mapk8b smo smo bmpr1aa bmpr1aa igf2a igf2a bmp7a bmp7a aida aida admp admp tdgf1 tdgf1 chrd chrd igf2b igf2b tob1a tob1a smad5 smad5 gli3 gli3 foxo3b foxo3b pou5f3 pou5f3 gdf6a gdf6a ctsba ctsba eve1 eve1 ctnnb2 ctnnb2 zeb2b zeb2b grip2a grip2a meis1b meis1b boc boc chrdl2 chrdl2 kif5ba kif5ba map2k4a map2k4a bmp2b bmp2b fbxl15 fbxl15 nup62l nup62l ccdc136b ccdc136b nup54 nup54 fcho1 fcho1 szl szl rest rest apc apc zmiz2 zmiz2 cav1 cav1 tsc22d3-3 tsc22d3-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acvr1lReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
med15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol [...] (802 aa)
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
acsl4aAcyl-CoA synthetase long chain family member 4a. (706 aa)
mapk8bMitogen-activated protein kinase 8; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. May play a role in the regulation of the circadian clock. (384 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
bmpr1aaReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
igf2aInsulin-like growth factor 2a. (197 aa)
bmp7aBone morphogenetic protein 7a. (432 aa)
aidaAxin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin- independent dorsalization pathway activated by axin/JNK-signaling. (303 aa)
admpAnti-dorsalizing morphogenic protein. (391 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
chrdChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa)
igf2bInsulin-like growth factor 2b. (212 aa)
tob1aTransducer of ERBB2, 1a. (322 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
gli3GLI family zinc finger 3. (1553 aa)
foxo3bForkhead box O3b. (651 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
ctsbaCathepsin B, a; Belongs to the peptidase C1 family. (330 aa)
eve1Even-skipped-like1. (224 aa)
ctnnb2Catenin, beta 2. (778 aa)
zeb2bZinc finger E-box-binding homeobox 2b. (1219 aa)
grip2aGlutamate receptor-interacting protein 2a. (736 aa)
meis1bMyeloid ecotropic viral integration 1. (388 aa)
bocBOC cell adhesion-associated, oncogene-regulated. (1032 aa)
chrdl2Chordin-like protein. (454 aa)
kif5baKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (968 aa)
map2k4aMitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
fbxl15F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway (By similarity). Required for dorsal/ventral pattern formation. (310 aa)
nup62lNucleoporin 62-like. (507 aa)
ccdc136bCoiled-coil domain-containing 136b. (358 aa)
nup54Nucleoporin 54. (353 aa)
fcho1F-BAR domain only protein 1. (1144 aa)
szlSzl protein. (282 aa)
restRE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa)
apcAPC regulator of WNT-signaling pathway. (2754 aa)
zmiz2Zinc finger, MIZ-type-containing 2. (902 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
tsc22d3-3Si:ch211-220e11.3. (207 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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