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| | csrp1a | Cysteine and glycine-rich protein 1a. (192 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | syk | Tyrosine-protein kinase. (608 aa) |
| | ptpra | Receptor-type tyrosine-protein phosphatase alpha. (831 aa) |
| | nrarpb | Notch-regulated ankyrin repeat-containing protein B; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (111 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | eaf2 | ELL-associated factor 2. (259 aa) |
| | zap70 | Tyrosine-protein kinase. (604 aa) |
| | gpc4 | Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | ftr82 | FinTRIM family, member 82. (573 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | pnn | Pinin, desmosome-associated protein. (667 aa) |
| | ip6k2a | Kinase; Belongs to the inositol phosphokinase (IPK) family. (463 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | nusap1 | Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). (446 aa) |
| | atp6v0a1a | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (834 aa) |
| | nav3 | Neuron navigator 3; May be involved in neuron regeneration; Belongs to the Nav/unc-53 family. (2269 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | hand2 | Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa) |
| | mkks | McKusick-Kaufman syndrome. (563 aa) |
| | lamc1 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa) |
| | def6a | Differentially expressed in FDCP 6 homolog. (612 aa) |
| | mxtx2 | Mix-type homeobox gene 2. (296 aa) |
| | gata5 | Transcription factor gata5. (383 aa) |
| | cyt1 | Type I cytokeratin, enveloping layer; Belongs to the intermediate filament family. (429 aa) |
| | lbx2 | Ladybird homeobox homolog 2 (Drosophila). (257 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | dnd1 | Dead end protein 1; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development. (411 aa) |
| | faf1 | Fas (TNFRSF6)-associated factor 1. (675 aa) |
| | pax3a | Transcription factor PAX3. (509 aa) |
| | tdgf1 | Teratocarcinoma-derived growth factor 1. (190 aa) |
| | itgav | Integrin, alpha V; Belongs to the integrin alpha chain family. (1045 aa) |
| | porcn | Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (442 aa) |
| | capn1a | Calpain 1, (mu/I) large subunit a; Belongs to the peptidase C2 family. (704 aa) |
| | arl6 | ADP-ribosylation factor-like protein 6; Probably involved in membrane protein trafficking at the base of the ciliary organelle. May function in cilia biogenesis. Isoform 2 is required for proper retinal function and organization. Belongs to the small GTPase superfamily. Arf family. (186 aa) |
| | igf1rb | Tyrosine-protein kinase receptor. (1380 aa) |
| | gmds | GDP-mannose 4,6 dehydratase. (370 aa) |
| | rab13 | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in endocytic recycling and may regulate the transport to the plasma membrane of transmembrane proteins. May regulate the assembly and the activity of tight jun [...] (200 aa) |
| | hdac1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa) |
| | gmnn | Geminin DNA replication inhibitor. (241 aa) |
| | pard6gb | Par-6 partitioning defective 6-like protein gamma. (434 aa) |
| | s1pr2 | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa) |
| | has2 | Hyaluronan synthase 2. (552 aa) |
| | cxcl12a | Chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (99 aa) |
| | tll1 | Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa) |
| | mitfa | Microphthalmia-associated transcription factor a. (412 aa) |
| | fbxo5 | F-box only protein 5; During embryonic development, regulates the integrity of the genome and therefore the cell cycle progression by preventing rereplication through an APC-Cdh1-dependent mechanism. (384 aa) |
| | arl6ip1 | ADP-ribosylation factor-like 6-interacting protein 1. (203 aa) |
| | apoa2 | Apolipoprotein A-II. (141 aa) |
| | prickle1a | Prickle homolog 1a. (793 aa) |
| | olig2 | Oligodendrocyte lineage transcription factor 2. (273 aa) |
| | bbs2 | Bardet-Biedl syndrome 2 protein homolog; Required for ciliogenesis. (715 aa) |
| | cxcr4b | Chemokine (C-X-C motif), receptor 4b; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | s1pr1 | Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. (362 aa) |
| | ackr3b | Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | csf3r | Colony-stimulating factor 3 receptor (granulocyte). (810 aa) |
| | prnpb | Prion protein b. (606 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | bace2 | Zgc:103530 protein; Belongs to the peptidase A1 family. (372 aa) |
| | nsmaf | Neutral sphingomyelinase (N-SMase) activation-associated factor. (911 aa) |
| | scrib | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | apln | Apelin; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Drives internalization of the apelin receptor (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis (By similarity). (77 aa) |
| | myb | V-myb avian myeloblastosis viral oncogene homolog. (641 aa) |
| | fzd2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa) |
| | cxcl12b | Chemokine (C-X-C motif) ligand 12B (Stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family. (97 aa) |
| | ret | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | uxs1 | UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa) |
| | ptenb | Phosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa) |
| | ryk | Receptor-like tyrosine kinase. (604 aa) |
| | ikzf1 | IKAROS family zinc finger 1 (Ikaros). (526 aa) |
| | cxcr4a | Chemokine (C-X-C motif) receptor 4a; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | atp1a1a.1 | Sodium/potassium-transporting ATPase subunit alpha. (1028 aa) |
| | celsr2 | Cadherin, EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2940 aa) |
| | tal1 | T-cell acute lymphocytic leukemia protein 1 homolog; Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the reg [...] (324 aa) |
| | kdm6al | Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1. (1311 aa) |
| | sdc4 | Syndecan 4. (207 aa) |
| | lmo4a | LIM domain only 4a. (167 aa) |
| | prmt5 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa) |
| | git2a | G protein-coupled receptor kinase-interacting ArfGAP 2a. (750 aa) |
| | amotl2a | Angiomotin-like 2a; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments and for cell movements during embryogenesis. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. (721 aa) |
| | zeb2b | Zinc finger E-box-binding homeobox 2b. (1219 aa) |
| | ackr3a | Atypical chemokine receptor 3a; Belongs to the G-protein coupled receptor 1 family. (398 aa) |
| | fzd3a | Transmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (685 aa) |
| | ppp1cab | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (678 aa) |
| | nanos3 | Nanos homolog 3; Belongs to the nanos family. (159 aa) |
| | psenen | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa) |
| | dll4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (683 aa) |
| | rhov | Novel protein similar to vertebrate ras homolog gene family, member V (RHOV). (235 aa) |
| | pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa) |
| | ppp4ca | Serine/threonine-protein phosphatase 4 catalytic subunit A; Protein phosphatase that regulates many processes such as microtubule organization at centrosomes; Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. (311 aa) |
| | eaf1 | ELL-associated factor 1. (253 aa) |
| | dusp6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa) |
| | pbx4 | Pre-B-cell leukemia transcription factor 4. (343 aa) |
| | pdgfaa | Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (194 aa) |
| | camk2g1 | Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1. (560 aa) |
| | cdx4 | Caudal type homeo box transcription factor 4. (270 aa) |
| | ocrl | OCRL inositol polyphosphate-5-phosphatase. (953 aa) |
| | sox10 | HMG-box transcription factor Sox10. (485 aa) |
| | spns2 | Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (105 aa) |
| | hoxb1a | Homeobox protein Hox-B1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (316 aa) |
| | csf1a | Colony-stimulating factor 1a (macrophage). (526 aa) |
| | cars2 | Cysteinyl-tRNA synthetase 2, mitochondrial. (566 aa) |
| | akap12b | A kinase (PRKA) anchor protein 12b. (1533 aa) |
| | bbs1 | Bardet-Biedl syndrome 1. (588 aa) |
| | olfm2a | Olfactomedin 2a. (483 aa) |
| | cdh5 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (767 aa) |
| | erbb3b | Erb-b2 receptor tyrosine kinase 3b. (1429 aa) |
| | wnt9a | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa) |
| | gnptab | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. (1219 aa) |
| | ccbe1 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Necessary for lymphangiogenesis, but is probably not part of either the vegfc-vegfr3 signaling or sox18-prox1 transcriptional pathways. Belongs to the CCBE1 family. (401 aa) |
| | bmp2b | Bone morphogenetic protein 2b. (411 aa) |
| | fto | FTO alpha-ketoglutarate-dependent dioxygenase. (567 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | nphp4 | Si:dkey-202c5.1 protein. (189 aa) |
| | loxa | Lysyl oxidase a. (408 aa) |
| | cald1b | Caldesmon 1b. (560 aa) |
| | gnb1a | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). (340 aa) |
| | nrarpa | Notch-regulated ankyrin repeat-containing protein A; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (112 aa) |
| | fn1a | Fibronectin 1a. (2480 aa) |
| | myo6a | Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1288 aa) |
| | lpp | LIM domain-containing preferred translocation partner in lipoma. (556 aa) |
| | spaw | Southpaw. (411 aa) |
| | clint1a | Clathrin interactor 1a. (633 aa) |
| | lrmda | Leucine-rich melanocyte differentiation-associated. (234 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | chd7 | Chromodomain helicase DNA-binding protein 7. (3140 aa) |
| | cthrc1a | Collagen triple helix repeat-containing 1a. (232 aa) |
| | sdc2 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (208 aa) |
| | kdm6a | Lysine (K)-specific demethylase 6A. (1390 aa) |
| | amot | Angiomotin. (1009 aa) |
| | prickle1b | Prickle homolog 1b. (863 aa) |
| | bbs10 | Bardet-Biedl syndrome 10. (151 aa) |
| | lzts2a | Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (741 aa) |
| | epb41l5 | Erythrocyte membrane protein band 4.1-like 5. (461 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | sbds | SBDS ribosome maturation factor. (250 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | ovol1a | Ovo-like zinc finger 1a. (319 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | peak1 | Pseudopodium-enriched atypical kinase 1. (1725 aa) |
| | lamb1a | Laminin, beta 1a. (1785 aa) |
| | mmp17b | Matrix metallopeptidase 17b. (613 aa) |
| | tsc2 | TSC complex subunit 2. (1674 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | flt4 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa) |
| | dusp2 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (333 aa) |
| | mcu | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by micu1 and micu2. At low Ca(2+) levels mcu activity is down-regulated by micu1 and micu2; at higher Ca(2+) levels micu1 increases mcu activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffe [...] (376 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | radil | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. (1124 aa) |
| | lama1 | Laminin, alpha 1. (3075 aa) |
| | plekhg5a | Pleckstrin homology domain-containing, family G (with RhoGef domain) member 5a. (1135 aa) |
| | notch1a | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa) |
| | sox32 | SRY-box transcription factor 32. (307 aa) |
| | apela | Apelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (aplnra and/or aplnrb). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating the apelin receptor. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast m [...] (58 aa) |
| | thsd7aa | Thrombospondin type-1 domain-containing protein 7A; Required for normal sprouting angiogenesis and normal embryonic development of intersegmental vessels (ISV). Required for normal function of the glomerular filtration barrier. Required for normal axon outgrowth on embryonic motor neurons at the level of the horizontal myoseptum. Required for normal expression of notch1b, suggesting that its functions in angiogenesis and neuron outgrowth are due to decreased expression of notch1b. Plays a role in actin cytoskeleton rearrangement (By similarity). (1684 aa) |
| | hdac4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa) |
| | ttc8 | Tetratricopeptide repeat domain 8. (268 aa) |
| | egfl7 | EGF-like-domain, multiple 7. (277 aa) |
| | capzb | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa) |
| | hs2st1a | Heparan sulfate 2-O-sulfotransferase 1a. (354 aa) |
| | plekhg5b | Pleckstrin homology domain-containing, family G (with RhoGef domain) member 5b. (1110 aa) |
| | ppp1cc | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa) |
| | dmxl2 | Dmx-like 2. (3049 aa) |
| | cbfb | Core-binding factor subunit beta. (201 aa) |
| | svep1 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1. (3615 aa) |
| | zeb2a | Zinc finger E-box-binding homeobox 2a. (1242 aa) |
| | spint1a | Serine peptidase inhibitor, Kunitz type 1 a. (523 aa) |
| | cntn2 | Contactin 2. (1040 aa) |
| | tnfsf18 | TNF superfamily member 18; Belongs to the tumor necrosis factor family. (202 aa) |
| | bcl2l16 | BCL2-like 16. (199 aa) |
| | bbs12 | Bardet-Biedl syndrome 12. (763 aa) |
| | nkx2.2a | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa) |
| | ccl25a | Chemokine (C-C motif) ligand 25a. (102 aa) |
| | igsf11 | Immunoglobulin superfamily member 11. (442 aa) |
