Your Input: | |
| | esco2 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa) |
| | rnf2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | col1a1a | Collagen, type I, alpha 1a. (1447 aa) |
| | ugdh | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (493 aa) |
| | prdm1a | PR domain-containing 1a, with ZNF domain. (776 aa) |
| | hmcn1 | Hemicentin 1. (5616 aa) |
| | sox9a | HMG box transcription factor Sox9a. (462 aa) |
| | cpsf4 | Cleavage and polyadenylation-specific factor 4. (271 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | atp6v0ca | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa) |
| | kcnk5b | Potassium channel, subfamily K, member 5b; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (448 aa) |
| | wls | Wnt ligand secretion mediator. (542 aa) |
| | osr1 | Protein odd-skipped-related 1; Transcriptional repressor (By similarity). Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification. Belongs to the Odd C2H2-type zinc-finger protein family. (264 aa) |
| | trim33 | E3 ubiquitin-protein ligase TRIM33; May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells. (1176 aa) |
| | ptch1 | Protein patched homolog 1. (1475 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (531 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | foxl1 | Forkhead transcription factor. (360 aa) |
| | gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | sec24d | SEC24 homolog D, COPII coat complex component. (1030 aa) |
| | sparc | Secreted protein, acidic, cysteine-rich (osteonectin). (291 aa) |
| | cyp26a1 | Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa) |
| | rarab | Retinoic acid receptor alpha-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins; Belongs to the nuclear hormone receptor family. NR1 subfamily. (458 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | lama5 | Laminin, alpha 5. (3664 aa) |
| | fgf10a | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa) |
| | taf1 | Transcription initiation factor TFIID subunit. (1947 aa) |
| | hdac1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa) |
| | pmm2 | Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (250 aa) |
| | fgf24 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | osr2 | Protein odd-skipped-related 2; Transcriptional repressor (By similarity). Required for pronephric kidney development; Belongs to the Odd C2H2-type zinc-finger protein family. (238 aa) |
| | arl6ip1 | ADP-ribosylation factor-like 6-interacting protein 1. (203 aa) |
| | fgf16 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa) |
| | crbn | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (446 aa) |
| | ccn2a | Novel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa) |
| | atp6v1b2 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | disp1 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa) |
| | aldh1a2 | Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | cog4 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in the vesicular trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity); Belongs to the COG4 family. (781 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | cyp26c1 | Cytochrome P450, family 26, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (554 aa) |
| | uxs1 | UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Essential during embryogenesis for craniofacial development. Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (418 aa) |
| | ext2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa) |
| | chaf1b | Chromatin assembly factor 1, subunit B. (613 aa) |
| | gpatch3 | G patch domain-containing 3. (669 aa) |
| | hhip | Hedgehog-interacting protein. (693 aa) |
| | lmo4a | LIM domain only 4a. (167 aa) |
| | frem1a | Fras1-related extracellular matrix 1a. (2167 aa) |
| | ndst1a | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a. (869 aa) |
| | plcb3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa) |
| | wnt2ba | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa) |
| | opa1 | Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). (966 aa) |
| | pbx4 | Pre-B-cell leukemia transcription factor 4. (343 aa) |
| | mif | Macrophage migration inhibitory factor. (115 aa) |
| | ahr2 | Aryl hydrocarbon receptor 2. (1027 aa) |
| | itga3b | Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1041 aa) |
| | rspo2 | R-spondin 2_variant1. (248 aa) |
| | pi4kaa | Phosphatidylinositol 4-kinase, catalytic, alpha a; Belongs to the PI3/PI4-kinase family. (2059 aa) |
| | cyp26b1 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa) |
| | frem2a | Fras1-like extracellular matrix protein 2a. (3119 aa) |
| | rerea | Arginine-glutamic acid dipeptide (RE) repeats a. (1531 aa) |
| | csnk1a1 | Casein kinase 1, alpha 1; Belongs to the protein kinase superfamily. (365 aa) |
| | tbx5b | T-box transcription factor 5b. (430 aa) |
| | aldh7a1 | Aldehyde dehydrogenase 7 family, member A1; Belongs to the aldehyde dehydrogenase family. (541 aa) |
| | rab11fip4a | Rab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | pknox1.1 | Homeodomain transcription factor Prep1. (433 aa) |
| | fibinb | Fin bud initiation factor; Essential for the initiation of pectoral fin bud formation. Potentially acts downstream of retinoic acid and Wnt signaling and is required for tbx5 expression in the lateral plate mesoderm of presumptive pectoral fin bud regions; Belongs to the FIBIN family. (210 aa) |
| | shox | Short stature homeobox. (285 aa) |
| | fignl1 | Fidgetin-like 1; Belongs to the AAA ATPase family. (661 aa) |
| | perp | P53 apoptosis effector-related to pmp22. (185 aa) |
| | eif2ak3 | Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa) |
| | kctd10 | Potassium channel tetramerisation domain containing 10. (313 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | extl3 | Exostosin-like glycosyltransferase 3; Belongs to the glycosyltransferase 47 family. (917 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | mtm1 | Myotubularin 1. (639 aa) |
| | tcf7 | Transcription factor 7. (355 aa) |
| | tmem260 | Transmembrane protein 260. (684 aa) |
| | masp1 | Mannan-binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (740 aa) |
| | med12 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa) |
| | creb3l2 | Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] (519 aa) |
| | cpsf1 | Cleavage and polyadenylation-specific factor 1. (1451 aa) |
| | polr1a | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1693 aa) |
| | cul4a | Cullin 4A; Belongs to the cullin family. (635 aa) |
| | talpid3 | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Belongs to the TALPID3 family. (1548 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | bhlha9 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis. (260 aa) |
| | szl | Szl protein. (282 aa) |
| | sar1b | Secretion-associated, Ras-related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa) |
| | sec23a | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa) |
| | irx1a | Iroquois homeobox protein 1, a. (426 aa) |
| | fras1 | Fraser extracellular matrix complex subunit 1. (4003 aa) |
| | apc | APC regulator of WNT-signaling pathway. (2754 aa) |
| | pdlim7 | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity). (419 aa) |
| | capzb | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa) |
| | camk2b | Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2. (388 aa) |
| | lrp4 | Low density lipoprotein receptor-related protein 4. (968 aa) |
| | bmp1a | Metalloendopeptidase. (986 aa) |
| | bcl2l16 | BCL2-like 16. (199 aa) |
| | med14 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1451 aa) |
