STRINGSTRING
snrpc snrpc cdh23 cdh23 OTOP1 OTOP1 ccdc80l1 ccdc80l1 tbx1 tbx1 pmm2 pmm2 popdc2 popdc2 esr2a esr2a chd7 chd7 eya1 eya1 ap1b1 ap1b1 cyfip2 cyfip2 pcdh15a pcdh15a foxj1a foxj1a slc12a2 slc12a2 cacna1da cacna1da otog otog myo7aa myo7aa megf10 megf10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
snrpcU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa)
cdh23Cadherin-related 23. (2883 aa)
OTOP1Otopetrin 1. (587 aa)
ccdc80l1Coiled-coil domain-containing 80-like 1. (852 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
pmm2Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (250 aa)
popdc2Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa)
esr2aEstrogen receptor beta2. (553 aa)
chd7Chromodomain helicase DNA-binding protein 7. (3140 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
ap1b1AP complex subunit beta. (947 aa)
cyfip2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1252 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
foxj1aForkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia. (458 aa)
slc12a2Solute carrier family 12 member 2. (1136 aa)
cacna1daVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2082 aa)
otogOtogelin. (3120 aa)
myo7aaMyosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2190 aa)
megf10Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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