node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ap1b1 | cdh23 | ENSDARP00000122116 | ENSDARP00000026525 | AP complex subunit beta. | Cadherin-related 23. | 0.563 |
cacna1da | cdh23 | ENSDARP00000137557 | ENSDARP00000026525 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Cadherin-related 23. | 0.463 |
cdh23 | ap1b1 | ENSDARP00000026525 | ENSDARP00000122116 | Cadherin-related 23. | AP complex subunit beta. | 0.563 |
cdh23 | cacna1da | ENSDARP00000026525 | ENSDARP00000137557 | Cadherin-related 23. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.463 |
cdh23 | myo7aa | ENSDARP00000026525 | ENSDARP00000143601 | Cadherin-related 23. | Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.984 |
cdh23 | pcdh15a | ENSDARP00000026525 | ENSDARP00000130788 | Cadherin-related 23. | Protocadherin-related 15a. | 0.996 |
disp1 | gli2a | ENSDARP00000065230 | ENSDARP00000010693 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | GLI family zinc finger 2a. | 0.644 |
disp1 | shha | ENSDARP00000065230 | ENSDARP00000125090 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.891 |
gli2a | disp1 | ENSDARP00000010693 | ENSDARP00000065230 | GLI family zinc finger 2a. | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | 0.644 |
gli2a | shha | ENSDARP00000010693 | ENSDARP00000125090 | GLI family zinc finger 2a. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.975 |
myo7aa | cdh23 | ENSDARP00000143601 | ENSDARP00000026525 | Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Cadherin-related 23. | 0.984 |
myo7aa | pcdh15a | ENSDARP00000143601 | ENSDARP00000130788 | Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Protocadherin-related 15a. | 0.934 |
pcdh15a | cdh23 | ENSDARP00000130788 | ENSDARP00000026525 | Protocadherin-related 15a. | Cadherin-related 23. | 0.996 |
pcdh15a | myo7aa | ENSDARP00000130788 | ENSDARP00000143601 | Protocadherin-related 15a. | Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.934 |
shha | disp1 | ENSDARP00000125090 | ENSDARP00000065230 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. | 0.891 |
shha | gli2a | ENSDARP00000125090 | ENSDARP00000010693 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | GLI family zinc finger 2a. | 0.975 |
shha | sox32 | ENSDARP00000125090 | ENSDARP00000138262 | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | SRY-box transcription factor 32. | 0.430 |
smyd1b | ttn.1 | ENSDARP00000130524 | ENSDARP00000107866 | SET and MYND domain-containing 1b. | Titin, tandem duplicate 1. | 0.672 |
sox32 | shha | ENSDARP00000138262 | ENSDARP00000125090 | SRY-box transcription factor 32. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.430 |
ttn.1 | smyd1b | ENSDARP00000107866 | ENSDARP00000130524 | Titin, tandem duplicate 1. | SET and MYND domain-containing 1b. | 0.672 |