STRINGSTRING
prdm1a prdm1a psen2 psen2 mylipa mylipa slc24a5 slc24a5 slc45a2 slc45a2 atp6v1e1b atp6v1e1b vps11 vps11 mitfa mitfa atp6v0d1 atp6v0d1 eif3ea eif3ea pmela pmela atp6ap1b atp6ap1b tyr tyr edn3b edn3b ece2b ece2b trpm7 trpm7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prdm1aPR domain-containing 1a, with ZNF domain. (776 aa)
psen2Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors; Belongs to the peptidase A22A family. (441 aa)
mylipaE3 ubiquitin-protein ligase MYLIP-A; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway. (472 aa)
slc24a5Sodium/potassium/calcium exchanger 5; Cation exchanger which plays a central role in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily. (513 aa)
slc45a2Solute carrier family 45 member 2. (554 aa)
atp6v1e1bATPase H+-transporting V1 subunit E1b. (226 aa)
vps11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (927 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
atp6v0d1V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) p [...] (350 aa)
eif3eaEukaryotic translation initiation factor 3 subunit E-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa)
pmelaPremelanosome protein a. (825 aa)
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
tyrTyrosinase. (535 aa)
edn3bEndothelin 3b. (153 aa)
ece2bEndothelin-converting enzyme 2b. (765 aa)
trpm7Transient receptor potential cation channel, subfamily M, member 7. (1787 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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