Your Input: | |
| | dmd | Dystrophin. (594 aa) |
| | rab5b | RAB5B, member RAS oncogene family. (214 aa) |
| | myl1 | Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa) |
| | dlst | Dihydrolipoamide S-succinyltransferase. (458 aa) |
| | dnajb6a | DnaJ heat shock protein family (Hsp40) member B6a. (316 aa) |
| | mybpc1 | Myosin-binding protein C1. (1167 aa) |
| | dnajb6b | DnaJ heat shock protein family (Hsp40) member B6b. (237 aa) |
| | vcp | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand [...] (806 aa) |
| | klhl41b | Kelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa) |
| | klhl40b | Kelch-like protein 40b; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (618 aa) |
| | chrnd | Cholinergic receptor, nicotinic, delta (muscle). (518 aa) |
| | rbfox1l | RNA binding protein fox-1 homolog 1-like; RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. (382 aa) |
| | hdac8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (378 aa) |
| | dag1 | Dystroglycan 1. (866 aa) |
| | chrna1 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa) |
| | hsp90aa1.1 | Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa) |
| | hspb11 | Heat shock protein beta-11; Belongs to the small heat shock protein (HSP20) family. (205 aa) |
| | smyd1a | SET and MYND domain-containing 1a. (465 aa) |
| | ryr1b | Ryanodine receptor 1b (skeletal). (5078 aa) |
| | rab5c | RAB5C, member RAS oncogene family. (221 aa) |
| | chchd4a | Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes (By similarity). Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitoc [...] (146 aa) |
| | ccdc78 | Coiled-coil domain-containing 78. (547 aa) |
| | cars1 | Cysteinyl-tRNA synthetase. (824 aa) |
| | fer1l6 | Fer-1-like family member 6. (1790 aa) |
| | klhl40a | Kelch-like protein 40a; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (612 aa) |
| | cacnb1 | Calcium channel, voltage-dependent, beta 1 subunit. (603 aa) |
| | bag3 | BCL2-associated athanogene 3. (480 aa) |
| | fbxo32 | F-box protein 32. (356 aa) |
| | rapsn | Receptor-associated protein of the synapse, 43kD. (412 aa) |
| | cryaba | Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (168 aa) |
| | cct5 | Chaperonin-containing TCP1, subunit 5 (epsilon). (541 aa) |
| | rbfox2 | RNA-binding fox-1 homolog 2. (241 aa) |
| | ptpmt1 | Protein tyrosine phosphatase, mitochondrial 1. (183 aa) |
| | aldh1a2 | Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | smyd2a | N-lysine methyltransferase SMYD2-A; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. (435 aa) |
| | ldb3a | Cypher/ZASP splice variant 1 gamma. (596 aa) |
| | cavin4b | Caveolae-associated protein 4b. (318 aa) |
| | ilk | Integrin-linked kinase. (452 aa) |
| | bves | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa) |
| | desma | Desmin a; Belongs to the intermediate filament family. (488 aa) |
| | gars1 | Glycyl-tRNA synthetase. (690 aa) |
| | mtmr12 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location. By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis. In skeletal muscle cells, does not regulate mtm1 subcellular localization. (736 aa) |
| | rnf121 | Ring finger protein 121. (331 aa) |
| | pgm5 | Phosphoglucomutase 5. (567 aa) |
| | col6a2 | Collagen, type VI, alpha 2. (1015 aa) |
| | washc4 | WASH complex subunit 4. (1173 aa) |
| | pleca | Plectin a. (4577 aa) |
| | golga2 | Cis-Golgi matrix protein GM130. (1028 aa) |
| | klhl41a | Kelch-like protein 41a; Involved in skeletal muscle development and differentiation. (599 aa) |
| | mstnb | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa) |
| | tnnt3a | Troponin T type 3a (skeletal, fast). (230 aa) |
| | pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa) |
| | scn4ab | Sodium channel protein type 4 subunit alpha B; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles. (1835 aa) |
| | mybpc2b | Myosin-binding protein Cb. (1111 aa) |
| | fhl1a | Four and a half LIM domains 1a. (297 aa) |
| | ttn.2 | Titin, tandem duplicate 2. (26265 aa) |
| | myot | Myotilin. (561 aa) |
| | col6a1 | Collagen, type VI, alpha 1. (1007 aa) |
| | ddx27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; Belongs to the DEAD box helicase family. (776 aa) |
| | vcla | Vinculin a. (1131 aa) |
| | gaa | Glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II); Belongs to the glycosyl hydrolase 31 family. (418 aa) |
| | tmod4 | Tropomodulin 4 (Muscle). (343 aa) |
| | actn2b | Actinin, alpha 2b. (894 aa) |
| | neb | Nebulin. (6177 aa) |
| | myof | Myoferlin. (2030 aa) |
| | myo18aa | Myosin XVIIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2454 aa) |
| | cemip2 | Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan. Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling. Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis. Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion. Involved in the restriction of endocardia [...] (1378 aa) |
| | dpm2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (83 aa) |
| | dio2 | Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (258 aa) |
| | tnnt3b | Troponin T type 3b (skeletal, fast). (284 aa) |
| | epg5 | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo (By similarity). (2532 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | mtm1 | Myotubularin 1. (639 aa) |
| | cryabb | Crystallin, alpha B, b; Belongs to the small heat shock protein (HSP20) family. (165 aa) |
| | actc1b | Actin, alpha 1, skeletal muscle. (377 aa) |
| | sil1 | SIL1 nucleotide exchange factor. (463 aa) |
| | smyd1b | SET and MYND domain-containing 1b. (486 aa) |
| | washc5 | WASH complex subunit 5; Acts at least in part as component of the WASH complex which seems to regulate washc1 nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting. Belongs to the strumpellin family. (1021 aa) |
| | lama2 | Laminin, alpha 2. (845 aa) |
| | mymk | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of mymx (By similarity). Belongs to the TMEM8 family. (220 aa) |
| | pyroxd1 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily. (485 aa) |
| | stac3 | SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membran [...] (334 aa) |
| | scn4aa | Sodium channel protein type 4 subunit alpha A; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.4/SCN4A subfamily. (1829 aa) |
| | adss1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa) |
| | gne | Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (732 aa) |
| | zbtb42 | Zinc finger and BTB domain-containing 42. (463 aa) |
| | nfixa | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (432 aa) |
| | csrp3 | Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa) |
| | smyhc1 | Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa) |
| | capzb | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa) |
| | inpp5ka | Inositol polyphosphate-5-phosphatase Ka. (476 aa) |
| | cbfb | Core-binding factor subunit beta. (201 aa) |
| | slc25a42 | Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate. (326 aa) |
| | npl | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). (307 aa) |
| | megf10 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa) |
| | plecb | Plectin b. (4535 aa) |
