STRINGSTRING
sox9a sox9a jag1b jag1b olfm1a olfm1a dlx1a dlx1a kat6a kat6a barx1 barx1 nkx2.5 nkx2.5 ptch1 ptch1 tgfb3 tgfb3 irx7 irx7 foxl1 foxl1 egr1 egr1 emx2 emx2 itga8 itga8 vgll2a vgll2a sox9b sox9b disp1 disp1 cnbpa cnbpa aldh1a2 aldh1a2 ptch2 ptch2 gfpt1 gfpt1 kat2b kat2b plcb3 plcb3 dmrt2b dmrt2b nolc1 nolc1 pbx4 pbx4 ccn6 ccn6 edn1 edn1 acvr2aa acvr2aa tshz2 tshz2 cyp26b1 cyp26b1 dlx2a dlx2a pappa2 pappa2 foxd3 foxd3 tp73 tp73 notch2 notch2 ece1 ece1 specc1 specc1 l1camb l1camb fsta fsta foxe1 foxe1 ostn ostn fgf3 fgf3 brpf1 brpf1 sufu sufu foxi1 foxi1 fras1 fras1 smarcal1 smarcal1 runx3 runx3 kat2a kat2a tfap2a tfap2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sox9aHMG box transcription factor Sox9a. (462 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
olfm1aOlfactomedin 1a. (485 aa)
dlx1aHomeobox protein Dlx1a. (252 aa)
kat6aHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2246 aa)
barx1Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family. (248 aa)
nkx2.5NK2 homeobox 5. (314 aa)
ptch1Protein patched homolog 1. (1475 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
irx7Iroquois homeodomain transcription factor Ziro7. (314 aa)
foxl1Forkhead transcription factor. (360 aa)
egr1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa)
emx2Empty spiracles homeobox 2. (247 aa)
itga8Integrin, alpha 8; Belongs to the integrin alpha chain family. (1059 aa)
vgll2aVestigial-like family member 2a. (296 aa)
sox9bHMG box transcription factor Sox9b. (407 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
cnbpaCCHC-type zinc finger, nucleic acid-binding protein a. (163 aa)
aldh1a2Aldehyde dehydrogenase 1 family, member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ptch2Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa)
gfpt1Glutamine--fructose-6-phosphate transaminase 1. (682 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1244 aa)
dmrt2bDoublesex and mab-3-related transcription factor 2b. (364 aa)
nolc1Nucleolar and coiled-body phosphoprotein 1. (1001 aa)
pbx4Pre-B-cell leukemia transcription factor 4. (343 aa)
ccn6WNT1 inducible signaling pathway protein 3. (338 aa)
edn1Endothelin 1. (188 aa)
acvr2aaSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (538 aa)
tshz2Teashirt zinc finger homeobox 2. (1020 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
pappa2Pappalysin 2. (1731 aa)
foxd3Forkhead box D3. (371 aa)
tp73Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa)
notch2Notch receptor 2. (2475 aa)
ece1Endothelin-converting enzyme 1. (752 aa)
specc1Sperm antigen with calponin homology and coiled-coil domains 1. (1035 aa)
l1cambNeural cell adhesion molecule L1.1; Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons (By similarity); Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. (1332 aa)
fstaFollistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa)
foxe1Forkhead box E1. (375 aa)
ostnOsteocrin. (134 aa)
fgf3Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa)
brpf1Bromodomain and PHD finger-containing, 1. (1248 aa)
sufuSuppressor of fused homolog. (485 aa)
foxi1Forkhead box I1. (377 aa)
fras1Fraser extracellular matrix complex subunit 1. (4003 aa)
smarcal1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity); Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (398 aa)
runx3Runt-related transcription factor. (438 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
tfap2aTranscription factor AP-2 alpha. (450 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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