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| | tbx16 | T-box transcription factor 16. (470 aa) |
| | atp1b1a | Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (306 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | nkx2.7 | NK2 transcription factor-related 7. (269 aa) |
| | alas1 | 5-aminolevulinate synthase. (621 aa) |
| | mtmr8 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (By similarity). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (632 aa) |
| | surf1 | SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family. (309 aa) |
| | cbfa2t3 | CBFA2/RUNX1 partner transcriptional co-repressor 3. (627 aa) |
| | nkx2.9 | NK2 transcription factor-related, locus 9 (Drosophila). (113 aa) |
| | calm2a | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa) |
| | ak2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa) |
| | gli2a | GLI family zinc finger 2a. (1439 aa) |
| | jag2b | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1254 aa) |
| | isl1 | Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa) |
| | dnmt1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | ncoa4 | Nuclear receptor coactivator 4. (576 aa) |
| | pax4 | Paired box 4. (344 aa) |
| | klhl42 | Kelch-like family, member 42. (472 aa) |
| | atp6v0ca | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa) |
| | gli2b | GLI family zinc finger 2b. (1225 aa) |
| | mtch2 | Mitochondrial carrier homolog 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa) |
| | pdx1 | Pancreatic and duodenal homeobox 1. (246 aa) |
| | gata3 | Transcription factor GATA-3. (438 aa) |
| | dlc | Delta-like protein C; Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (664 aa) |
| | rpl27 | 60S ribosomal protein L27; Component of the large ribosomal subunit. (136 aa) |
| | emx3 | Empty spiracles homeobox 3. (233 aa) |
| | pak4 | Non-specific serine/threonine protein kinase. (664 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | hand2 | Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa) |
| | mcrs1 | Microspherule protein 1. (472 aa) |
| | sox21b | Transcription factor Sox-21-B; Acts as a negative regulator of transcription. (245 aa) |
| | osr1 | Protein odd-skipped-related 1; Transcriptional repressor (By similarity). Regulates mesoderm versus endoderm differentiation during gastrulation to regulate kidney versus vascular cell fate. Acts upstream of pax2a in kidney development and functions in glomerular maturation, after podocyte specification. Belongs to the Odd C2H2-type zinc-finger protein family. (264 aa) |
| | lgsn | Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (668 aa) |
| | irx7 | Iroquois homeodomain transcription factor Ziro7. (314 aa) |
| | hsf4 | Heat shock transcription factor 4. (286 aa) |
| | zic2a | ZIC family member 2 (Odd-paired homolog, Drosophila), A. (445 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | six1b | Homeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa) |
| | rps27.1 | 40S ribosomal protein S27. (84 aa) |
| | wt1a | WT1 transcription factor a. (419 aa) |
| | spi1b | SI:bY184L24.2.1 (Transcription factor spi1). (296 aa) |
| | hsp70l | Novel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. (643 aa) |
| | b4galt7 | Xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I). (317 aa) |
| | glra4a | Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa) |
| | ppdpfa | Pancreatic progenitor cell differentiation and proliferation factor A; Probable regulator of exocrine pancreas development. (117 aa) |
| | wdr73 | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics; Belongs to the WD repeat WDR73 family. (376 aa) |
| | jak1 | Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa) |
| | pax3a | Transcription factor PAX3. (509 aa) |
| | diras1a | DIRAS family, GTP-binding RAS-like 1a. (195 aa) |
| | mb | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa) |
| | flvcr1 | FLVCR heme transporter 1. (527 aa) |
| | csrnp1a | Cysteine-serine-rich nuclear protein 1a. (514 aa) |
| | mpx | Myeloid-specific peroxidase. (893 aa) |
| | cdk10 | Cyclin-dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa) |
| | etv2 | ETS variant transcription factor 2. (366 aa) |
| | tmem165 | GDT1 family protein. (305 aa) |
| | enpp2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (850 aa) |
| | jak3 | Tyrosine-protein kinase. (1103 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | hdac1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa) |
| | mnx1 | Motor neuron and pancreas homeobox 1. (311 aa) |
| | thap11 | THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). (257 aa) |
| | cebpa | CCAAT/enhancer-binding protein. (288 aa) |
| | rgs18 | Regulator of G protein-signaling 18. (208 aa) |
| | atoh8 | Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 AND ZFPM1. During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation. (266 aa) |
| | snrnp70 | Small nuclear ribonucleoprotein 70 (U1). (495 aa) |
| | mitfa | Microphthalmia-associated transcription factor a. (412 aa) |
| | klf17 | Kruppel-like factor 17. (409 aa) |
| | olig2 | Oligodendrocyte lineage transcription factor 2. (273 aa) |
| | rps29 | Ribosomal protein S29. (56 aa) |
| | fgf16 | Fibroblast growth factor 16; Plays a crucial role in pectoral fin bud outgrowth. Belongs to the heparin-binding growth factors family. (203 aa) |
| | ackr3b | Atypical chemokine receptor 3b; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | csf3r | Colony-stimulating factor 3 receptor (granulocyte). (810 aa) |
| | cdk9 | Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. (393 aa) |
| | notch3 | Notch receptor 3. (2468 aa) |
| | dhps | Deoxyhypusine synthase. (361 aa) |
| | zfand3 | Zinc finger, AN1-type domain 3. (226 aa) |
| | sox3 | Transcription factor Sox-3; Transcriptional activator. (300 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | prox1a | Prospero homeobox 1a. (739 aa) |
| | id2a | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a. (137 aa) |
| | leo1 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). PAF1C seems to be required for multiple steps in cardiac formation. Involved in heart development and required for differentiation of the atrioventricular boundary. Required for neural crest cell development. (696 aa) |
| | wnt1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). Involved in neurogenesis. Performs a partially redundant function with wnt10b in the formation of the midbrain-hindbrain boundary (MHB) organizer. In the hindbrain, mediates lateral inhibition of boundary cell specification, probably via up-regulation of proneural and Delta gene expression in non-boundary cells; localized expression of wnt1 in boundary cells is maintained vi [...] (370 aa) |
| | mastl | Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of arpp19 and ensa at 'Ser- 62' and 'Ser-74', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the ppp2r2d (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...] (860 aa) |
| | ruvbl2 | RuvB-like 2; Has double-stranded DNA-stimulated ATPase activity. Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin. Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome- activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway where it negatively regulates expression of ER stress [...] (463 aa) |
| | foxi3a | Forkhead box I3a. (353 aa) |
| | sf3b1 | Splicing factor 3b, subunit 1. (1315 aa) |
| | epas1b | Endothelial PAS domain protein 1b. (834 aa) |
| | hoxd4a | Homeobox protein Hox-D4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (256 aa) |
| | gata2a | GATA-binding protein 2a. (456 aa) |
| | sdc4 | Syndecan 4. (207 aa) |
| | lmo4a | LIM domain only 4a. (167 aa) |
| | klf8 | Kruppel-like factor 8. (343 aa) |
| | lrsam1 | Leucine-rich repeat and sterile alpha motif-containing 1. (721 aa) |
| | adnp2a | ADNP homeobox 2a. (962 aa) |
| | jam3b | Junctional adhesion molecule 3B; Junctional adhesion protein that mediates heterotypic cell- cell interactions to regulate different cellular processes (By similarity). During myogenesis, it is involved in myocyte fusion through the binding of jam2a on neighboring myocytes. (333 aa) |
| | hipk2 | Homeodomain-interacting protein kinase 2. (1220 aa) |
| | foxe3 | Forkhead box E3. (422 aa) |
| | rasa3 | RAS p21 protein activator 3. (833 aa) |
| | clp1 | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phospho [...] (443 aa) |
| | yap1 | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Required for expansion of the neural plate and neural plate border zone progenitor pools. Acts as a direct regulator of pax3 expression via interaction with tead1. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin netwo [...] (442 aa) |
| | dld | Delta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa) |
| | syf2 | Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing as component of the spliceosome. (238 aa) |
| | gfer | Sulfhydryl oxidase. (191 aa) |
| | meis1b | Myeloid ecotropic viral integration 1. (388 aa) |
| | cdipt | CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (213 aa) |
| | camk1da | Calcium/calmodulin-dependent protein kinase 1Da; Belongs to the protein kinase superfamily. (433 aa) |
| | rx1 | Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (330 aa) |
| | zdhhc15b | Palmitoyltransferase ZDHHC15B; Catalyzes palmitoylation of Cys residues on target proteins. (332 aa) |
| | klf4 | Kruppel-like factor 4. (340 aa) |
| | atxn7 | Ataxin 7. (866 aa) |
| | cdx4 | Caudal type homeo box transcription factor 4. (270 aa) |
| | tet2 | Tet methylcytosine dioxygenase 2. (1715 aa) |
| | birc5a | Baculoviral IAP repeat-containing 5a. (190 aa) |
| | mettl22 | Methyltransferase-like 22. (357 aa) |
| | pcsk9 | Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (667 aa) |
| | rfng | Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Regulates neurogenesis in the hindbrain; involved in boundary cell specification via Notch- mediated activation of wnt1 expression. (362 aa) |
| | capn12 | Calpain 12; Belongs to the peptidase C2 family. (713 aa) |
| | dmbx1a | Diencephalon/mesencephalon homeobox protein 1-A; Required for eye and tectum development. May act as a transcriptional repressor. (383 aa) |
| | marcksa | Myristoylated alanine-rich protein kinase C substrate a. (236 aa) |
| | scn12aa | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1932 aa) |
| | prdm16 | Si:ch211-263k4.2. (927 aa) |
| | insm1a | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa) |
| | rab11fip4a | Rab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa) |
| | camk4 | Calcium/calmodulin-dependent protein kinase IV; Belongs to the protein kinase superfamily. (364 aa) |
| | etv5a | ETS variant transcription factor 5a. (524 aa) |
| | tp73 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa) |
| | dnmt3bb.2 | DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1448 aa) |
| | nr2e3 | Nuclear receptor subfamily 2, group E, member 3. (426 aa) |
| | her8a | Hairy-related 8a. (221 aa) |
| | nrarpa | Notch-regulated ankyrin repeat-containing protein A; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (112 aa) |
| | notch2 | Notch receptor 2. (2475 aa) |
| | grna | Granulin a. (1049 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | htr1ab | 5-hydroxytryptamine (serotonin) receptor 1A b. (413 aa) |
| | wnt8a | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. May be involved in the specification of the spatial patterns of expression of Gsc and other regulatory genes leading to the establishment of the embryonic axis; Belongs to the Wnt family. (387 aa) |
| | cdh6 | Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (794 aa) |
| | adamts9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9. (1461 aa) |
| | zgc:153115 | Zgc:153115. (250 aa) |
| | diras1b | DIRAS family, GTP-binding RAS-like 1b. (198 aa) |
| | il7r | Interleukin 7 receptor. (372 aa) |
| | nfil3 | Nuclear factor interleukin-3-regulated protein; May act as a transcriptional regulator of a number of proteins of the circadian clock. (468 aa) |
| | kdm6bb | Lysine (K)-specific demethylase 6B, b. (1719 aa) |
| | plcg1 | Phosphoinositide phospholipase C. (1020 aa) |
| | pld1a | Phospholipase. (1022 aa) |
| | prpf8 | Pre-mRNA-processing factor 8. (2342 aa) |
| | hcfc1b | Host cell factor C1b. (1993 aa) |
| | birc5b | Baculoviral IAP repeat-containing 5b. (144 aa) |
| | wnt16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa) |
| | cox5aa | Cytochrome c oxidase subunit 5Aa. (141 aa) |
| | kmt2a | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4218 aa) |
| | sbds | SBDS ribosome maturation factor. (250 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | gckr | Glucokinase (hexokinase 4) regulator. (281 aa) |
| | tal2 | T-cell acute lymphocytic leukemia 2. (109 aa) |
| | wdr43 | WD repeat domain 43. (650 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (998 aa) |
| | ap2a1 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (959 aa) |
| | cdc73 | Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (530 aa) |
| | med12 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (2175 aa) |
| | ndrg4 | NDRG family member 4. (352 aa) |
| | nrg1 | Neuregulin 1. (730 aa) |
| | nbeal2 | Neurobeachin-like protein 2; Involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis; Belongs to the WD repeat neurobeachin family. (2788 aa) |
| | agtpbp1 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1153 aa) |
| | dner | Delta/notch-like EGF repeat-containing. (744 aa) |
| | jak2a | Tyrosine-protein kinase. (1095 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | kif3b | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (775 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | agrn | Agrin. (1926 aa) |
| | cdh4 | Cadherin 4, type 1, R-cadherin (retinal); Cadherins are calcium-dependent cell adhesion proteins. (931 aa) |
| | bmp5 | Bone morphogenetic protein 5. (446 aa) |
| | lama1 | Laminin, alpha 1. (3075 aa) |
| | rest | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. (854 aa) |
| | tfr1a | Transferrin receptor 1a. (770 aa) |
| | scn5lab | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1954 aa) |
| | pepd | Peptidase D. (496 aa) |
| | irx1a | Iroquois homeobox protein 1, a. (426 aa) |
| | eps15l1b | Epidermal growth factor receptor pathway substrate 15 like 1. (535 aa) |
| | snw1 | SNW domain-containing 1. (536 aa) |
| | cox5ab | Cytochrome c oxidase subunit 5Ab. (138 aa) |
| | krit1 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa) |
| | apc | APC regulator of WNT-signaling pathway. (2754 aa) |
| | nop14 | NOP14 nucleolar protein homolog (yeast). (767 aa) |
| | rbpms | RNA-binding protein, mRNA-processing factor. (160 aa) |
| | sf3a3 | Splicing factor 3a, subunit 3. (501 aa) |
| | smarcal1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA (By similarity); Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (398 aa) |
| | hal | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (654 aa) |
| | dnajb1a | DnaJ heat shock protein family (Hsp40) member B1a. (335 aa) |
| | iqcg | Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (camk4) activity; contributes to the regulation of camk4 signaling cascades. Plays a role in the regulation of definitive hematopoiesis via its effects on camk4. Belo [...] (346 aa) |
| | trpm7 | Transient receptor potential cation channel, subfamily M, member 7. (1787 aa) |
| | tcf7l1b | Transcription factor 7-like 1-B; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis. Belongs to the TCF/LEF family. (585 aa) |
| | csf1ra | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa) |
| | lpar3 | Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (353 aa) |
| | npas4l | Neuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa) |
| | pax6b | Paired box 6b. (450 aa) |
| | cdx1b | Caudal type homeodomain protein. (255 aa) |
| | tfap2a | Transcription factor AP-2 alpha. (450 aa) |
