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ush1ga ush1ga chm chm cdh23 cdh23 s1pr2 s1pr2 dcdc2b dcdc2b atp2b1a atp2b1a tecta tecta kremen1 kremen1 get1 get1 ush1c ush1c pax5 pax5 eya1 eya1 ap1b1 ap1b1 slc26a2 slc26a2 grhl1 grhl1 pcdh15a pcdh15a grxcr1a grxcr1a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ush1gaUsher syndrome 1Ga (autosomal recessive). (472 aa)
chmRab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
cdh23Cadherin-related 23. (2883 aa)
s1pr2Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa)
dcdc2bDoublecortin domain-containing 2B. (447 aa)
atp2b1aCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1228 aa)
tectaTectorin alpha. (2201 aa)
kremen1Kringle-containing transmembrane protein 1. (465 aa)
get1Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane. (170 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
pax5Paired box 5. (396 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
ap1b1AP complex subunit beta. (947 aa)
slc26a2Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (699 aa)
grhl1Grainyhead-like transcription factor 1. (613 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
grxcr1aGlutaredoxin and cysteine-rich domain-containing 1 a. (295 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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