node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cacna1fa | grm6b | ENSDARP00000123455 | ENSDARP00000030907 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Glutamate receptor, metabotropic 6b. | 0.451 |
cc2d2a | eys-2 | ENSDARP00000150494 | ENSDARP00000144515 | Coiled-coil and C2 domain-containing 2A. | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | 0.440 |
cc2d2a | rpgrip1 | ENSDARP00000150494 | ENSDARP00000118806 | Coiled-coil and C2 domain-containing 2A. | RPGR-interacting protein 1. | 0.735 |
cerkl | eys-2 | ENSDARP00000098560 | ENSDARP00000144515 | Ceramide kinase-like. | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | 0.745 |
cerkl | rpgrip1 | ENSDARP00000098560 | ENSDARP00000118806 | Ceramide kinase-like. | RPGR-interacting protein 1. | 0.476 |
cerkl | ush2a | ENSDARP00000098560 | ENSDARP00000080636 | Ceramide kinase-like. | Usher syndrome 2A (autosomal recessive, mild). | 0.615 |
eys-2 | cc2d2a | ENSDARP00000144515 | ENSDARP00000150494 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | Coiled-coil and C2 domain-containing 2A. | 0.440 |
eys-2 | cerkl | ENSDARP00000144515 | ENSDARP00000098560 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | Ceramide kinase-like. | 0.745 |
eys-2 | pde6c | ENSDARP00000144515 | ENSDARP00000138871 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | Phosphodiesterase. | 0.662 |
eys-2 | rpgrip1 | ENSDARP00000144515 | ENSDARP00000118806 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | RPGR-interacting protein 1. | 0.408 |
eys-2 | ush2a | ENSDARP00000144515 | ENSDARP00000080636 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | Usher syndrome 2A (autosomal recessive, mild). | 0.863 |
grm6b | cacna1fa | ENSDARP00000030907 | ENSDARP00000123455 | Glutamate receptor, metabotropic 6b. | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | 0.451 |
lamb1a | lamc1 | ENSDARP00000131540 | ENSDARP00000024860 | Laminin, beta 1a. | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | 0.937 |
lamb1a | ush2a | ENSDARP00000131540 | ENSDARP00000080636 | Laminin, beta 1a. | Usher syndrome 2A (autosomal recessive, mild). | 0.522 |
lamc1 | lamb1a | ENSDARP00000024860 | ENSDARP00000131540 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Laminin, beta 1a. | 0.937 |
lamc1 | ush2a | ENSDARP00000024860 | ENSDARP00000080636 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | Usher syndrome 2A (autosomal recessive, mild). | 0.643 |
myo7aa | ush1c | ENSDARP00000143601 | ENSDARP00000104974 | Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Usher syndrome 1C (Autosomal recessive, severe). | 0.994 |
myo7aa | ush2a | ENSDARP00000143601 | ENSDARP00000080636 | Myosin VIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Usher syndrome 2A (autosomal recessive, mild). | 0.879 |
pde6c | eys-2 | ENSDARP00000138871 | ENSDARP00000144515 | Phosphodiesterase. | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. | 0.662 |
rpgrip1 | cc2d2a | ENSDARP00000118806 | ENSDARP00000150494 | RPGR-interacting protein 1. | Coiled-coil and C2 domain-containing 2A. | 0.735 |