STRINGSTRING
pcgf1 pcgf1 ewsr1b ewsr1b flt1 flt1 esco2 esco2 col1a1b col1a1b col1a1a col1a1a prkci prkci kif11 kif11 smarcd1 smarcd1 plod2 plod2 smo smo pink1 pink1 prdm12b prdm12b nedd1 nedd1 chm chm noto noto ewsr1a ewsr1a pes pes glra4a glra4a nek1 nek1 tdgf1 tdgf1 dnajc9 dnajc9 adarb1a adarb1a lingo1b lingo1b scrt2 scrt2 sulf1 sulf1 fer1l6 fer1l6 terfa terfa utp11 utp11 gli3 gli3 olig2 olig2 dharma dharma ppm1e ppm1e abcc4 abcc4 pou5f3 pou5f3 rdh10a rdh10a gdf6a gdf6a pogza pogza foxh1 foxh1 chaf1b chaf1b plk1 plk1 ctnnb2 ctnnb2 evx2 evx2 kifbp kifbp shank3a shank3a syngap1b syngap1b msi1 msi1 ptk7a ptk7a actr10 actr10 psenen psenen gria2a gria2a skib skib vsx1 vsx1 stat3 stat3 gbx1 gbx1 ids ids cdx4 cdx4 gba gba ocrl ocrl mak16 mak16 cluap1 cluap1 twist2 twist2 twistnb twistnb mtor mtor rab11fip4a rab11fip4a pard3ab pard3ab fshb fshb gnl3 gnl3 clu clu gle1 gle1 fbxw7 fbxw7 grna grna ccnk ccnk ppp1r12a ppp1r12a col1a2 col1a2 prpf8 prpf8 fut8a fut8a col17a1a col17a1a cenph cenph lrrk2 lrrk2 tert tert pla2g6 pla2g6 slc6a6b slc6a6b psd2 psd2 ptpn12 ptpn12 mib1 mib1 wnt5b wnt5b gabra1 gabra1 psen1 psen1 rtn4b rtn4b glrx2 glrx2 hmgcs1 hmgcs1 exosc3 exosc3 ptmab ptmab adgrg1 adgrg1 evx1 evx1 ndr2 ndr2 csf1ra csf1ra bmp1a bmp1a nkx2.2a nkx2.2a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pcgf1Polycomb group RING finger protein 1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. (295 aa)
ewsr1bEwing sarcoma breakpoint region 1b. (579 aa)
flt1Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
esco2N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa)
col1a1bCollagen, type I, alpha 1b. (1449 aa)
col1a1aCollagen, type I, alpha 1a. (1447 aa)
prkciProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa)
kif11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa)
smarcd1SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 1. (510 aa)
plod2Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform. (754 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
pink1PTEN-induced kinase 1. (574 aa)
prdm12bPR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (366 aa)
nedd1NEDD1 gamma-tubulin ring complex targeting factor. (677 aa)
chmRab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa)
notoNotochord homeobox. (241 aa)
ewsr1aEWS RNA-binding protein 1a. (626 aa)
pesPescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa)
glra4aGlycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
nek1NIMA-related kinase 1. (1200 aa)
tdgf1Teratocarcinoma-derived growth factor 1. (190 aa)
dnajc9DnaJ (Hsp40) homolog, subfamily C, member 9. (252 aa)
adarb1aAdenosine deaminase RNA-specific B1a. (720 aa)
lingo1bLeucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. (622 aa)
scrt2Scratch family zinc finger 2. (312 aa)
sulf1Sulfatase FP1c. (1099 aa)
fer1l6Fer-1-like family member 6. (1790 aa)
terfaTelomeric repeat-binding factor a. (574 aa)
utp11U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa)
gli3GLI family zinc finger 3. (1553 aa)
olig2Oligodendrocyte lineage transcription factor 2. (273 aa)
dharmaDharma. (192 aa)
ppm1eProtein phosphatase, Mg2+/Mn2+-dependent, 1E. (633 aa)
abcc4ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1327 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
rdh10aRetinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
pogzaPogo transposable element-derived with ZNF domain a. (1277 aa)
foxh1Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa)
chaf1bChromatin assembly factor 1, subunit B. (613 aa)
plk1Serine/threonine-protein kinase PLK. (595 aa)
ctnnb2Catenin, beta 2. (778 aa)
evx2Even-skipped homeobox 2. (418 aa)
kifbpKIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (631 aa)
shank3aSH3 and multiple ankyrin repeat domains 3a. (1509 aa)
syngap1bSynaptic Ras GTPase-activating protein 1b. (1507 aa)
msi1Musashi RNA-binding protein 1. (297 aa)
ptk7aProtein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa)
actr10Actin-related protein 10; Belongs to the actin family. (415 aa)
psenenGamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa)
gria2aGlutamate receptor, ionotropic, AMPA 2a. (875 aa)
skibV-ski avian sarcoma viral oncogene homolog b. (695 aa)
vsx1Visual system homeobox 1; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems; Belongs to the paired homeobox family. (340 aa)
stat3Signal transducer and activator of transcription. (806 aa)
gbx1Gastrulation brain homeobox 1. (316 aa)
idsIduronate 2-sulfatase. (561 aa)
cdx4Caudal type homeo box transcription factor 4. (270 aa)
gbaGlucosylceramidase. (518 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (953 aa)
mak16Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa)
cluap1Clusterin-associated protein 1 homolog; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Belongs to the CLUAP1 family. (427 aa)
twist2Twist2. (163 aa)
twistnbDNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
rab11fip4aRab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa)
pard3abPar-3 family cell polarity regulator alpha, b. (1332 aa)
fshbFollicle-stimulating hormone beta subunit. (130 aa)
gnl3Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa)
cluClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
gle1Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa)
fbxw7F-box and WD repeat domain-containing 7. (544 aa)
grnaGranulin a. (1049 aa)
ccnkCyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). (526 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
col1a2Collagen, type I, alpha 2. (1352 aa)
prpf8Pre-mRNA-processing factor 8. (2342 aa)
fut8aAlpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (581 aa)
col17a1aCollagen, type XVII, alpha 1a. (1408 aa)
cenphCentromere protein H. (233 aa)
lrrk2Leucine-rich repeat kinase 2. (2532 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa)
pla2g6Phospholipase A2, group VI (cytosolic, calcium-independent). (824 aa)
slc6a6bTransporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (574 aa)
psd2Pleckstrin and Sec7 domain-containing 2. (837 aa)
ptpn12Protein tyrosine phosphatase non-receptor type 12. (170 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
gabra1Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (459 aa)
psen1Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa)
rtn4bReticulon. (876 aa)
glrx2Glutaredoxin 2. (170 aa)
hmgcs13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa)
exosc3Exosome component 3. (247 aa)
ptmabProthymosin alpha-B. (106 aa)
adgrg1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa)
evx1Even-skipped homeobox 1. (377 aa)
ndr2Nodal-related 2. (505 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
bmp1aMetalloendopeptidase. (986 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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