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| | pcgf1 | Polycomb group RING finger protein 1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. (295 aa) |
| | ewsr1b | Ewing sarcoma breakpoint region 1b. (579 aa) |
| | flt1 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa) |
| | esco2 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (By similarity). Essential for early development. (609 aa) |
| | col1a1b | Collagen, type I, alpha 1b. (1449 aa) |
| | col1a1a | Collagen, type I, alpha 1a. (1447 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | kif11 | Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1062 aa) |
| | smarcd1 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily d, member 1. (510 aa) |
| | plod2 | Procollagen lysine 2-oxoglutarate 5-dioxygenase 2b isoform. (754 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | pink1 | PTEN-induced kinase 1. (574 aa) |
| | prdm12b | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (366 aa) |
| | nedd1 | NEDD1 gamma-tubulin ring complex targeting factor. (677 aa) |
| | chm | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (666 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | ewsr1a | EWS RNA-binding protein 1a. (626 aa) |
| | pes | Pescadillo; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (583 aa) |
| | glra4a | Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa) |
| | nek1 | NIMA-related kinase 1. (1200 aa) |
| | tdgf1 | Teratocarcinoma-derived growth factor 1. (190 aa) |
| | dnajc9 | DnaJ (Hsp40) homolog, subfamily C, member 9. (252 aa) |
| | adarb1a | Adenosine deaminase RNA-specific B1a. (720 aa) |
| | lingo1b | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1-B; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. (622 aa) |
| | scrt2 | Scratch family zinc finger 2. (312 aa) |
| | sulf1 | Sulfatase FP1c. (1099 aa) |
| | fer1l6 | Fer-1-like family member 6. (1790 aa) |
| | terfa | Telomeric repeat-binding factor a. (574 aa) |
| | utp11 | U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (250 aa) |
| | gli3 | GLI family zinc finger 3. (1553 aa) |
| | olig2 | Oligodendrocyte lineage transcription factor 2. (273 aa) |
| | dharma | Dharma. (192 aa) |
| | ppm1e | Protein phosphatase, Mg2+/Mn2+-dependent, 1E. (633 aa) |
| | abcc4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1327 aa) |
| | pou5f3 | POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa) |
| | rdh10a | Retinol dehydrogenase 10-A; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | pogza | Pogo transposable element-derived with ZNF domain a. (1277 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | chaf1b | Chromatin assembly factor 1, subunit B. (613 aa) |
| | plk1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | ctnnb2 | Catenin, beta 2. (778 aa) |
| | evx2 | Even-skipped homeobox 2. (418 aa) |
| | kifbp | KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development. (631 aa) |
| | shank3a | SH3 and multiple ankyrin repeat domains 3a. (1509 aa) |
| | syngap1b | Synaptic Ras GTPase-activating protein 1b. (1507 aa) |
| | msi1 | Musashi RNA-binding protein 1. (297 aa) |
| | ptk7a | Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa) |
| | actr10 | Actin-related protein 10; Belongs to the actin family. (415 aa) |
| | psenen | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. (101 aa) |
| | gria2a | Glutamate receptor, ionotropic, AMPA 2a. (875 aa) |
| | skib | V-ski avian sarcoma viral oncogene homolog b. (695 aa) |
| | vsx1 | Visual system homeobox 1; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems; Belongs to the paired homeobox family. (340 aa) |
| | stat3 | Signal transducer and activator of transcription. (806 aa) |
| | gbx1 | Gastrulation brain homeobox 1. (316 aa) |
| | ids | Iduronate 2-sulfatase. (561 aa) |
| | cdx4 | Caudal type homeo box transcription factor 4. (270 aa) |
| | gba | Glucosylceramidase. (518 aa) |
| | ocrl | OCRL inositol polyphosphate-5-phosphatase. (953 aa) |
| | mak16 | Protein MAK16 homolog; Plays an essential role in early embryonic development. (305 aa) |
| | cluap1 | Clusterin-associated protein 1 homolog; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Belongs to the CLUAP1 family. (427 aa) |
| | twist2 | Twist2. (163 aa) |
| | twistnb | DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters (By similarity). (390 aa) |
| | mtor | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa) |
| | rab11fip4a | Rab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa) |
| | pard3ab | Par-3 family cell polarity regulator alpha, b. (1332 aa) |
| | fshb | Follicle-stimulating hormone beta subunit. (130 aa) |
| | gnl3 | Guanine nucleotide-binding protein-like 3; May play a role in regulating cellular proliferation. (561 aa) |
| | clu | Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa) |
| | gle1 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (694 aa) |
| | fbxw7 | F-box and WD repeat domain-containing 7. (544 aa) |
| | grna | Granulin a. (1049 aa) |
| | ccnk | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). (526 aa) |
| | ppp1r12a | Protein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa) |
| | col1a2 | Collagen, type I, alpha 2. (1352 aa) |
| | prpf8 | Pre-mRNA-processing factor 8. (2342 aa) |
| | fut8a | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (581 aa) |
| | col17a1a | Collagen, type XVII, alpha 1a. (1408 aa) |
| | cenph | Centromere protein H. (233 aa) |
| | lrrk2 | Leucine-rich repeat kinase 2. (2532 aa) |
| | tert | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa) |
| | pla2g6 | Phospholipase A2, group VI (cytosolic, calcium-independent). (824 aa) |
| | slc6a6b | Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (574 aa) |
| | psd2 | Pleckstrin and Sec7 domain-containing 2. (837 aa) |
| | ptpn12 | Protein tyrosine phosphatase non-receptor type 12. (170 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | wnt5b | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa) |
| | gabra1 | Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (459 aa) |
| | psen1 | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins (By similarity); Belongs to the peptidase A22A family. (456 aa) |
| | rtn4b | Reticulon. (876 aa) |
| | glrx2 | Glutaredoxin 2. (170 aa) |
| | hmgcs1 | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (519 aa) |
| | exosc3 | Exosome component 3. (247 aa) |
| | ptmab | Prothymosin alpha-B. (106 aa) |
| | adgrg1 | Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (648 aa) |
| | evx1 | Even-skipped homeobox 1. (377 aa) |
| | ndr2 | Nodal-related 2. (505 aa) |
| | csf1ra | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa) |
| | bmp1a | Metalloendopeptidase. (986 aa) |
| | nkx2.2a | Homeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa) |
